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    EIF2AK2 eukaryotic translation initiation factor 2 alpha kinase 2 [ Homo sapiens (human) ]

    Gene ID: 5610, updated on 18-Apr-2017
    Official Symbol
    EIF2AK2provided by HGNC
    Official Full Name
    eukaryotic translation initiation factor 2 alpha kinase 2provided by HGNC
    Primary source
    HGNC:HGNC:9437
    See related
    Ensembl:ENSG00000055332 MIM:176871; Vega:OTTHUMG00000100962
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PKR; PRKR; EIF2AK1; PPP1R83
    Summary
    The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
    Orthologs
    Location:
    2p22.2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 2 NC_000002.12 (37099210..37157065, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (37332281..37384190, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene striatin Neighboring gene uncharacterized LOC107985867 Neighboring gene HEAT repeat containing 5B Neighboring gene G-patch domain containing 11 Neighboring gene ARL14 effector protein pseudogene Neighboring gene sulfotransferase family 6B member 1 Neighboring gene ribosomal protein L31 pseudogene 16

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Overexpression of ADAR1 increases the levels of gp120, p24, and Nef in HIV-1 producer cells, which requires inhibition of the RNA-activated protein kinase PKR PubMed
    env Inactivation of PKR has an inhibitory effect on gp120-induced caspase-3 activation PubMed
    env HIV-1 gp120 induces activation of PKR and its translocation from cytoplasm to nucleus in neuronal cell lines PubMed
    Envelope surface glycoprotein gp160, precursor env Activation of PKR decreases HIV-1 Env expression and knockdown of PKR expression increases intracellular HIV-1 Env expression in human and murine cell lines PubMed
    Nef nef The small molecule PKR inhibitor C16 inhibits the IFITM3-induced suppression of HIV-1 Gag, Vif, and Nef protein expression PubMed
    nef Overexpression of ADAR1 increases the levels of gp120, p24, and Nef in HIV-1 producer cells, which requires inhibition of the RNA-activated protein kinase PKR PubMed
    Pr55(Gag) gag The small molecule PKR inhibitor C16 inhibits the IFITM3-induced suppression of HIV-1 Gag, Vif, and Nef protein expression PubMed
    gag HIV-1 Gag is identified to have a physical interaction with eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    Tat tat PKR directly interacts with HIV-1 Tat and phosphorylates the first exon of Tat exclusively at five Ser/Thr residues (T23, T40, S46, S62, and S68), which inhibits Tat-mediated provirus transcription PubMed
    tat PKR-mediated Tat phosphorylation inhibits Tat nuclear localization, and disrupts Tat binding to HIV-1 TAR RNA and interaction with cyclin T1 in HeLa cells PubMed
    tat Mutations in HIV-1 Tat that prevent Tat phosphorylation by PKR result in an up to 4-fold decrease in HIV-1 LTR transactivation by Tat PubMed
    tat HIV-1 Tat-induction of IL-10 dysregulation is associated with PKR activation in primary blood monocytes PubMed
    tat Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including PKR, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed
    tat PKR enhances HIV-1 Tat-mediated activation of NF-kappaB activation and transcriptional induction of the HIV-1 LTR promoter in the murine HL3T1 cell line PubMed
    tat HIV-1 Tat downregulates the steady-state amount of p68 kinase (PKR) in interferon-treated HeLa cells stably expressing Tat PubMed
    tat HIV-1 Tat inhibits the activation, activity and autophosphorylation of PKR, suggesting a potential mechanism by which HIV could suppress the interferon system PubMed
    tat Binding of HIV-1 Tat to PKR has been mapped to residues 40-58 of Tat, overlapping the hydrophobic core and basic region of Tat PubMed
    tat HIV-1 Tat is phosphorylated by PKR on serine 62, threonine 64 and serine 68 PubMed
    tat HIV-1 Tat interacts with interferon-inducible enzymes 2-5A synthetase and dsRNA-dependent protein kinase to influence the rate of translation and protein synthesis in vitro PubMed
    Vif vif The small molecule PKR inhibitor C16 inhibits the IFITM3-induced suppression of HIV-1 Gag, Vif, and Nef protein expression PubMed
    Vpu vpu The expression of eukaryotic translation initiation factor 2-alpha kinase 2 is enhanced in Vpu-deficient HIV-1-infected cells as compared to that in wild-type-infected cells PubMed
    capsid gag Overexpression of ADAR1 increases the levels of gp120, p24, and Nef in HIV-1 producer cells, which requires inhibition of the RNA-activated protein kinase PKR PubMed

    Go to the HIV-1, Human Interaction Database

    • Antiviral mechanism by IFN-stimulated genes, organism-specific biosystem (from REACTOME)
      Antiviral mechanism by IFN-stimulated genes, organism-specific biosystemThe ISG proteins generated by IFN pathways plays key roles in the induction of innate and adaptive immune responses.
    • Ceramide signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      Ceramide signaling pathway, organism-specific biosystem
      Ceramide signaling pathway
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
      Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Epstein-Barr virus infection, conserved biosystem (from KEGG)
      Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Hepatitis C, organism-specific biosystem (from KEGG)
      Hepatitis C, organism-specific biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • Hepatitis C, conserved biosystem (from KEGG)
      Hepatitis C, conserved biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
      Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Host Interactions with Influenza Factors, organism-specific biosystem (from REACTOME)
      Host Interactions with Influenza Factors, organism-specific biosystemInfection of a human host cell with influenza virus triggers an array of host processes that interfere with viral replication, notably the production of type I interferon. The viral NS1 protein plays...
    • ISG15 antiviral mechanism, organism-specific biosystem (from REACTOME)
      ISG15 antiviral mechanism, organism-specific biosystemInterferon-stimulated gene 15 (ISG15) is a member of the ubiquitin-like (Ubl) family. It is strongly induced upon exposure to type I Interferons (IFNs), viruses, bacterial LPS, and other stresses. On...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Infectious disease, organism-specific biosystem (from REACTOME)
      Infectious disease, organism-specific biosystem
      Infectious disease
    • Influenza A, organism-specific biosystem (from KEGG)
      Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Influenza A, conserved biosystem (from KEGG)
      Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Influenza Infection, organism-specific biosystem (from REACTOME)
      Influenza Infection, organism-specific biosystemFor centuries influenza epidemics have plagued man, and influenza was probably the disease described by Hippocrates in 412 BC. Today it remains a major cause of morbidity and mortality worldwide with...
    • Inhibition of PKR, organism-specific biosystem (from REACTOME)
      Inhibition of PKR, organism-specific biosystemThe key role played by PKR in the innate response to virus infection is emphasized by the large number of viruses that encode PKR inhibitors.
    • Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
      Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
    • Interferon Signaling, organism-specific biosystem (from REACTOME)
      Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
    • Measles, organism-specific biosystem (from KEGG)
      Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Measles, conserved biosystem (from KEGG)
      Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • NS1 Mediated Effects on Host Pathways, organism-specific biosystem (from REACTOME)
      NS1 Mediated Effects on Host Pathways, organism-specific biosystemViral NS1 protein is a nuclear, dimeric protein that is highly expressed in infected cells and has dsRNA-binding activity. The RNA-binding domain lies within the N-terminal portion of the protein. Th...
    • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Signaling events mediated by TCPTP, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by TCPTP, organism-specific biosystem
      Signaling events mediated by TCPTP
    • Translation Factors, organism-specific biosystem (from WikiPathways)
      Translation Factors, organism-specific biosystemProtein synthesis is the ultimate step of gene expression and a key control point for regulation. In particular, it enables cells to rapidly manipulate protein production without new mRNA synthesis, ...
    • Type II interferon signaling (IFNG), organism-specific biosystem (from WikiPathways)
      Type II interferon signaling (IFNG), organism-specific biosystemAdapted from Raza et al. (2008). This pathway is initiated by IFNG binding to its receptor and a subsequent phosphorylation cascade involving a number of the JAK and STAT family of proteins. Several ...
    • Viral carcinogenesis, organism-specific biosystem (from KEGG)
      Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
    • Viral carcinogenesis, conserved biosystem (from KEGG)
      Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC126524

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    double-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    eukaryotic translation initiation factor 2alpha kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein phosphatase regulator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    activation of MAPKK activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to amino acid starvation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    defense response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum unfolded protein response IEA
    Inferred from Electronic Annotation
    more info
     
    evasion or tolerance by virus of host immune response TAS
    Traceable Author Statement
    more info
     
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of osteoblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of viral genome replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of NIK/NF-kappaB signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of chemokine production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cytokine production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of stress-activated MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein autophosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of NLRP3 inflammasome complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of hematopoietic progenitor cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of hematopoietic stem cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of hematopoietic stem cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of translational initiation by eIF2 alpha phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    response to interferon-alpha IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to toxic substance IEA
    Inferred from Electronic Annotation
    more info
     
    response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    translation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ribosome TAS
    Traceable Author Statement
    more info
    PubMed 
    Preferred Names
    interferon-induced, double-stranded RNA-activated protein kinase
    Names
    P1/eIF-2A protein kinase
    double stranded RNA activated protein kinase
    eIF-2A protein kinase 2
    interferon-inducible elF2alpha kinase
    p68 kinase
    protein kinase R
    protein kinase, interferon-inducible double stranded RNA dependent
    protein phosphatase 1, regulatory subunit 83
    tyrosine-protein kinase EIF2AK2
    NP_001129123.1
    NP_001129124.1
    NP_002750.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030351.1 RefSeqGene

      Range
      5001..56910
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001135651.2NP_001129123.1  interferon-induced, double-stranded RNA-activated protein kinase isoform a

      See identical proteins and their annotated locations for NP_001129123.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1 and 2 both encode the same protein (isoform a).
      Source sequence(s)
      AC007899, BC040851, BU687340
      Consensus CDS
      CCDS1786.1
      UniProtKB/Swiss-Prot
      P19525
      UniProtKB/TrEMBL
      Q8IW76
      Related
      ENSP00000233057.4, OTTHUMP00000126954, ENST00000233057.8, OTTHUMT00000218571
      Conserved Domains (3) summary
      smart00220
      Location:267534
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00358
      Location:101166
      DSRM; Double-stranded RNA binding motif
      cd14047
      Location:260536
      STKc_EIF2AK2_PKR; Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 2 or Protein Kinase regulated by RNA
    2. NM_001135652.2NP_001129124.1  interferon-induced, double-stranded RNA-activated protein kinase isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. The 5' UTR splice pattern of this transcript has not been determined.
      Source sequence(s)
      AC007899, BC101475, BU687340
      Consensus CDS
      CCDS46259.1
      UniProtKB/Swiss-Prot
      P19525
      Related
      ENSP00000385014.1, OTTHUMP00000201320, ENST00000405334.5, OTTHUMT00000325486
      Conserved Domains (3) summary
      smart00220
      Location:252493
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00358
      Location:101166
      DSRM; Double-stranded RNA binding motif
      cl21453
      Location:262495
      PKc_like; Protein Kinases, catalytic domain
    3. NM_002759.3NP_002750.1  interferon-induced, double-stranded RNA-activated protein kinase isoform a

      See identical proteins and their annotated locations for NP_002750.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 both encode the same protein (isoform a).
      Source sequence(s)
      AC007899, BC040851, BU687340
      Consensus CDS
      CCDS1786.1
      UniProtKB/Swiss-Prot
      P19525
      UniProtKB/TrEMBL
      Q8IW76
      Related
      ENSP00000378559.2, ENST00000395127.6
      Conserved Domains (3) summary
      smart00220
      Location:267534
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00358
      Location:101166
      DSRM; Double-stranded RNA binding motif
      cd14047
      Location:260536
      STKc_EIF2AK2_PKR; Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 2 or Protein Kinase regulated by RNA

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p7 Primary Assembly

      Range
      37099210..37157065 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011532987.2XP_011531289.1  interferon-induced, double-stranded RNA-activated protein kinase isoform X1

      See identical proteins and their annotated locations for XP_011531289.1

      UniProtKB/Swiss-Prot
      P19525
      Conserved Domains (3) summary
      smart00220
      Location:267534
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00358
      Location:101166
      DSRM; Double-stranded RNA binding motif
      cd14047
      Location:260536
      STKc_EIF2AK2_PKR; Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 2 or Protein Kinase regulated by RNA
    2. XM_017004503.1XP_016859992.1  interferon-induced, double-stranded RNA-activated protein kinase isoform X2

    Alternate CHM1_1.1

    Genomic

    1. NC_018913.2 Alternate CHM1_1.1

      Range
      37261631..37313513 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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