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    PRKCH protein kinase C eta [ Homo sapiens (human) ]

    Gene ID: 5583, updated on 2-Dec-2016
    Official Symbol
    PRKCHprovided by HGNC
    Official Full Name
    protein kinase C etaprovided by HGNC
    Primary source
    HGNC:HGNC:9403
    See related
    Ensembl:ENSG00000027075 MIM:605437; Vega:OTTHUMG00000152341
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PKCL; PKC-L; PRKCL; nPKC-eta
    Summary
    Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. Mutations in this gene are associated with susceptibility to cerebral infarction. [provided by RefSeq, Sep 2015]
    Orthologs
    Location:
    14q23.1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 14 NC_000014.9 (61280953..61550980)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (61788515..62017698)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927756 Neighboring gene solute carrier family 38 member 6 Neighboring gene uncharacterized LOC105378182 Neighboring gene transmembrane protein 30B Neighboring gene uncharacterized LOC105370525 Neighboring gene uncharacterized LOC101927780 Neighboring gene uncharacterized LOC400221 Neighboring gene HIF1A antisense RNA 1 Neighboring gene hypoxia inducible factor 1 alpha subunit

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Ischemic stroke
    MedGen: C0948008 OMIM: 601367 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    A genome-wide association study for reading and language abilities in two population cohorts.
    NHGRI GWA Catalog
    Genetics of rheumatoid arthritis contributes to biology and drug discovery.
    NHGRI GWA Catalog
    Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity.
    NHGRI GWA Catalog
    Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population.
    NHGRI GWA Catalog

    Replication interactions

    Interaction Pubs
    Knockdown of protein kinase C, eta (PRKCH) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 activates forward trafficking and surface clustering of NMDA receptors in membrane microdomains by a PKA-dependent phosphorylation of the NR1 C-terminal Ser897, followed by a PKC-dependent phosphorylation of Ser896 PubMed
    env Down modulation of the interaction between HIV-1 gp120 and CD4 by TPA is blocked by protein kinase C (PKC) inhibitors, suggesting PKC may play an important role in HIV-1 infection PubMed
    env c-FLIPL inhibits Bax activation via modulating PKC expression at the transcriptional level involving AP-2 during gp120 treatment PubMed
    env Pre-treatment of endothelial cells with fibroblast growth factor 2 (FGF2) protects cells from HIV-1 gp120 angiotoxicity; this protection is regulated by crosstalk among the ERK, PI3K-AKT and PKC signaling pathways PubMed
    env Induction of apoptosis in cell cultures through binding of HIV-1 gp120 or gp160 to CXCR4 involves protein kinase C, basic fibroblast growth factor, caspase-3, and the pro-apoptotic molecule Bax PubMed
    env HIV-1 gp120 increases the levels of calcium-dependent and -independent PKC isozymes; the most striking change is observed in PKC-zeta isozyme levels PubMed
    env A specific interaction between CD4 and HIV-1 gp120 is required for phosphorylation of CD4, which could involve protein kinase C PubMed
    env IL-16 induces rapid translocation of PKC from the cytosol to the membrane in CD4+ cells; PKC inhibitors completely block IL-16-induced lymphocyte migration as well as the motile response induced by HIV-1 gp120 and anti-CD4 antibody binding to CD4 PubMed
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160-induced AP-1 complex formation is dependent upon protein tyrosine phosphorylation and is abolished by inhibitors of protein kinase C, but it is unaffected by calcium channel blockers or cyclosporine A PubMed
    Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to cytoplasmic domain residues 828-848 of HIV-1 gp41 inhibits pKC-catalysed phosphorylation of a protein substrate PubMed
    env A synthetic peptide containing residues 581-597 from HIV-1 gp41 inhibits protein kinase C (pkC)-mediated phosphorylation of the CD3 gamma-chain in intact cells and directly inhibits partially purified pkC PubMed
    Nef nef The N-terminus of HIV-1 Nef associates with PKC eta PubMed
    Tat tat Phospholipase C/protein kinase C signaling pathway-dependent phosphorylation of p44/42 and JNK MAP kinases participates partially in IL-1beta induction by TAT PubMed
    tat Protein kinase C is required for HIV-1 Tat-mediated transactivation of the viral LTR promoter, indicating protein kinase C regulates the process of HIV-1 transactivation and may play a role in the transition of HIV from latency to productive growth PubMed
    tat Protein kinase C phosphorylates HIV-1 Tat on serine residue 46 PubMed
    tat HIV-1 Tat activates protein kinase C, resulting in the induction of TNF-alpha, IL-6 and IL-10 expression and the secretion of MCP-1 PubMed
    matrix gag Protein kinase C (PKC) phosphorylates HIV-1 Matrix on serine residue 111 resulting in a shift in localization of Matrix from the cytosol to the cellular membrane, suggesting a myristoyl-protein switch regulated by PKC phosphorylation PubMed
    retropepsin gag-pol Phosphorylation of human recombinant vimentin by PKC inhibits the proteolytic processing of the vimentin head domain by HIV-1 protease PubMed
    reverse transcriptase gag-pol HIV-1 RT heterodimer expressed in bacteria can be phosphorylated in vitro by several purified mammalian protein kinases including auto-activated protein kinase (PK), CKII, cytosolic protamine kinase (CPK), myelin basic protein kinase 1 (MBPK1), and PRKC PubMed

    Go to the HIV-1, Human Interaction Database

    • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
      Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
    • Effects of PIP2 hydrolysis, organism-specific biosystem (from REACTOME)
      Effects of PIP2 hydrolysis, organism-specific biosystemHydrolysis of phosphatidyl inositol-bisphosphate (PIP2) by phospholipase C (PLC) produces diacylglycerol (DAG) and inositol triphosphate (IP3). Both are potent second messengers. IP3 diffuses into th...
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      Endothelins, organism-specific biosystem
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    • Inflammatory mediator regulation of TRP channels, organism-specific biosystem (from KEGG)
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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC5363, MGC26269

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    Ral GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    calcium-independent protein kinase C activity IEA
    Inferred from Electronic Annotation
    more info
     
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase C activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of glial cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    platelet activation TAS
    Traceable Author Statement
    more info
     
    positive regulation of B cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of glial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of keratinocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of macrophage derived foam cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of protein localization to plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    protein kinase C signaling IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of bicellular tight junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cell-cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    protein kinase C eta type
    NP_006246.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011514.1 RefSeqGene

      Range
      4647..234184
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_006255.4NP_006246.2  protein kinase C eta type

      See identical proteins and their annotated locations for NP_006246.2

      Status: REVIEWED

      Source sequence(s)
      AK290183, AL138996, AW008462, BC037268, BP367689
      Consensus CDS
      CCDS9752.1
      UniProtKB/Swiss-Prot
      P24723
      Related
      ENSP00000329127, OTTHUMP00000179058, ENST00000332981, OTTHUMT00000276974
      Conserved Domains (4) summary
      cd04014
      Location:8140
      C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon
      smart00220
      Location:355614
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05590
      Location:359681
      STKc_nPKC_eta; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C eta
      pfam00130
      Location:246298
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p7 Primary Assembly

      Range
      61280953..61550980
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017021458.1XP_016876947.1  

      UniProtKB/Swiss-Prot
      P24723
      Related
      ENSP00000450981, OTTHUMP00000246352, ENST00000555082, OTTHUMT00000413390
      Conserved Domains (3) summary
      smart00220
      Location:194453
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05590
      Location:198520
      STKc_nPKC_eta; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C eta
      pfam00130
      Location:85137
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    2. XM_011536956.1XP_011535258.1  

      Conserved Domains (4) summary
      cd04014
      Location:8140
      C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon
      smart00220
      Location:355477
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam00130
      Location:246298
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      cl21453
      Location:359492
      PKc_like; Protein Kinases, catalytic domain
    3. XM_011536957.1XP_011535259.1  

      Conserved Domains (4) summary
      cd04014
      Location:8140
      C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon
      smart00220
      Location:355478
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam00130
      Location:246298
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      cl21453
      Location:359478
      PKc_like; Protein Kinases, catalytic domain
    4. XM_017021459.1XP_016876948.1  

    5. XM_011536954.2XP_011535256.1  

      Conserved Domains (3) summary
      smart00220
      Location:276535
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05590
      Location:280602
      STKc_nPKC_eta; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C eta
      pfam00130
      Location:167219
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    6. XM_011536955.1XP_011535257.1  

      Conserved Domains (3) summary
      smart00220
      Location:275534
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05590
      Location:279601
      STKc_nPKC_eta; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C eta
      pfam00130
      Location:166218
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    Alternate CHM1_1.1

    Genomic

    1. NC_018925.2 Alternate CHM1_1.1

      Range
      61727577..61957119
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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