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    Cxcl15 chemokine (C-X-C motif) ligand 15 [ Mus musculus (house mouse) ]

    Gene ID: 20309, updated on 10-Oct-2017
    Official Symbol
    Cxcl15provided by MGI
    Official Full Name
    chemokine (C-X-C motif) ligand 15provided by MGI
    Primary source
    MGI:MGI:1339941
    See related
    Ensembl:ENSMUSG00000029375 Vega:OTTMUSG00000055507
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Il8; weche; Scyb15; lungkine
    Expression
    Restricted expression toward lung adult (RPKM 125.0) See more
    Location:
    5 E1; 5 44.78 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (90794534..90803067)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (91223560..91232093)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene platelet factor 4 Neighboring gene chemokine (C-X-C motif) ligand 3 Neighboring gene chemokine (C-X-C motif) ligand 1 Neighboring gene chemokine (C-X-C motif) ligand 2

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemokine signaling pathway, organism-specific biosystem (from KEGG)
      Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Chemokine signaling pathway, conserved biosystem (from KEGG)
      Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Chemokine signaling pathway, organism-specific biosystem (from WikiPathways)
      Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Lung fibrosis, organism-specific biosystem (from WikiPathways)
      Lung fibrosis, organism-specific biosystem(Nanoparticle) induced lung fibrosis pathway. Under construction. Note! Mouse homologues for SERPINA1 and SFTPA2 are missing and the pathway currently contains the human equivalents. Other users are ...

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    CXCR3 chemokine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    chemokine activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    T cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    chemokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    defense response IEA
    Inferred from Electronic Annotation
    more info
     
    hemopoiesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    inflammatory response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neutrophil chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of leukocyte chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    response to lipopolysaccharide IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    C-X-C motif chemokine 15
    Names
    interleukin 8
    small inducible cytokine subfamily B, member 15
    small-inducible cytokine B15

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011339.2NP_035469.1  C-X-C motif chemokine 15 precursor

      See identical proteins and their annotated locations for NP_035469.1

      Status: VALIDATED

      Source sequence(s)
      AK142955
      Consensus CDS
      CCDS19418.1
      UniProtKB/Swiss-Prot
      Q9WVL7
      Related
      ENSMUSP00000031322.6, OTTMUSP00000072363, ENSMUST00000031322.6, OTTMUST00000137385
      Conserved Domains (1) summary
      cd00273
      Location:2790
      Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      90794534..90803067
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 129S1/SvImJ

    Genomic

    1. NT_109599.1 Reference GRCm38.p4 129S1/SvImJ

      Range
      23698..32212 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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