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    Tlr7 toll-like receptor 7 [ Mus musculus (house mouse) ]

    Gene ID: 170743, updated on 25-May-2017
    Official Symbol
    Tlr7provided by MGI
    Official Full Name
    toll-like receptor 7provided by MGI
    Primary source
    MGI:MGI:2176882
    See related
    Ensembl:ENSMUSG00000044583 Vega:OTTMUSG00000019578
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Orthologs
    Location:
    X; X F5
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (167304926..167330574, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (163742863..163768460, complement)

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene thymosin, beta 4, X chromosome Neighboring gene toll-like receptor 8 Neighboring gene phosphoribosyl pyrophosphate synthetase 2 Neighboring gene predicted gene 6744

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Chemically induced (ENU) (2) 

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    drug binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    siRNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    single-stranded RNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    I-kappaB phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    MyD88-dependent toll-like receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    defense response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    immune response IEA
    Inferred from Electronic Annotation
    more info
     
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    microglial cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of NF-kappaB import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of chemokine production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interferon-alpha biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interferon-alpha biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interferon-beta biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interferon-gamma biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-6 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of interleukin-8 biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-8 production ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    toll-like receptor 7 signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    toll-like receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    early phagosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    receptor complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Preferred Names
    toll-like receptor 7
    Names
    Toll like receptor 7

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290755.1NP_001277684.1  toll-like receptor 7 isoform a precursor

      See identical proteins and their annotated locations for NP_001277684.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the shorter isoform (a). Variants 1, 2, 3, and 4 encode the same isoform (a).
      Source sequence(s)
      AJ812654, AK036549, AL731735, BY543663
      Consensus CDS
      CCDS72469.1
      UniProtKB/Swiss-Prot
      P58681
      UniProtKB/TrEMBL
      Q548J0
      Related
      ENSMUSP00000107787.1, OTTMUSP00000021130, ENSMUST00000112161.7, OTTMUST00000046751
      Conserved Domains (4) summary
      smart00255
      Location:8911036
      TIR; Toll - interleukin 1 - resistance
      cd00116
      Location:453720
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:497519
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:290350
      LRR_8; Leucine rich repeat
    2. NM_001290756.1NP_001277685.1  toll-like receptor 7 isoform a precursor

      See identical proteins and their annotated locations for NP_001277685.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' region, compared to variant 1. Variants 1, 2, 3, and 4 encode the same isoform (a).
      Source sequence(s)
      AJ812654, AK036549, AL731735, BY543663
      Consensus CDS
      CCDS72469.1
      UniProtKB/Swiss-Prot
      P58681
      UniProtKB/TrEMBL
      Q548J0
      Conserved Domains (4) summary
      smart00255
      Location:8911036
      TIR; Toll - interleukin 1 - resistance
      cd00116
      Location:453720
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:497519
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:290350
      LRR_8; Leucine rich repeat
    3. NM_001290757.1NP_001277686.1  toll-like receptor 7 isoform a precursor

      See identical proteins and their annotated locations for NP_001277686.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two alternate exons and uses an alternate splice site in the 5' region, and initiates translation from an alternate upstream start codon, compared to variant 1. Variants 1, 2, 3, and 4 encode the same isoform (a).
      Source sequence(s)
      AK036549, AL731735, BY543663
      Consensus CDS
      CCDS30531.1
      UniProtKB/Swiss-Prot
      P58681
      UniProtKB/TrEMBL
      Q548J0
      Related
      ENSMUSP00000107789.1, OTTMUSP00000021133, ENSMUST00000112164.1, OTTMUST00000046755
      Conserved Domains (4) summary
      smart00255
      Location:8911036
      TIR; Toll - interleukin 1 - resistance
      cd00116
      Location:453720
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:497519
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:290350
      LRR_8; Leucine rich repeat
    4. NM_001290758.1NP_001277687.1  toll-like receptor 7 isoform b

      See identical proteins and their annotated locations for NP_001277687.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate exon in the 5' region and initiates translation at an alternate upstream start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is longer than isoform a.
      Source sequence(s)
      AJ812652, AK036549, AL731735, BY204351, BY543663
      UniProtKB/TrEMBL
      Q548J0, Q599W9
      Conserved Domains (4) summary
      smart00255
      Location:8941039
      TIR; Toll - interleukin 1 - resistance
      cd00116
      Location:456723
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:500522
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:293353
      LRR_8; Leucine rich repeat
    5. NM_133211.4NP_573474.1  toll-like receptor 7 isoform a precursor

      See identical proteins and their annotated locations for NP_573474.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate exons in the 5' region and initiates translation from an alternate upstream start codon, compared to variant 1. Variants 1, 2, 3, and 4 encode the same isoform (a).
      Source sequence(s)
      AK036549, AL731735, BY543663
      Consensus CDS
      CCDS30531.1
      UniProtKB/Swiss-Prot
      P58681
      UniProtKB/TrEMBL
      Q548J0
      Related
      ENSMUSP00000061853.5, OTTMUSP00000021129, ENSMUST00000060719.11, OTTMUST00000046750
      Conserved Domains (4) summary
      smart00255
      Location:8911036
      TIR; Toll - interleukin 1 - resistance
      cd00116
      Location:453720
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:497519
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:290350
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

      Range
      167304926..167330574 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247786.1XP_011246088.1  toll-like receptor 7 isoform X2

      See identical proteins and their annotated locations for XP_011246088.1

      UniProtKB/Swiss-Prot
      P58681
      UniProtKB/TrEMBL
      Q548J0
      Conserved Domains (4) summary
      smart00255
      Location:8911036
      TIR; Toll - interleukin 1 - resistance
      cd00116
      Location:453720
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:497519
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:290350
      LRR_8; Leucine rich repeat
    2. XM_006528713.1XP_006528776.1  toll-like receptor 7 isoform X1

      See identical proteins and their annotated locations for XP_006528776.1

      Conserved Domains (4) summary
      smart00255
      Location:8941039
      TIR; Toll - interleukin 1 - resistance
      cd00116
      Location:456723
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:500522
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:293353
      LRR_8; Leucine rich repeat
    3. XM_011247785.1XP_011246087.1  toll-like receptor 7 isoform X2

      See identical proteins and their annotated locations for XP_011246087.1

      UniProtKB/Swiss-Prot
      P58681
      UniProtKB/TrEMBL
      Q548J0
      Conserved Domains (4) summary
      smart00255
      Location:8911036
      TIR; Toll - interleukin 1 - resistance
      cd00116
      Location:453720
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:497519
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:290350
      LRR_8; Leucine rich repeat
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