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    Nod2 nucleotide-binding oligomerization domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 257632, updated on 12-Mar-2017
    Official Symbol
    Nod2provided by MGI
    Official Full Name
    nucleotide-binding oligomerization domain containing 2provided by MGI
    Primary source
    MGI:MGI:2429397
    See related
    Ensembl:ENSMUSG00000055994 Vega:OTTMUSG00000029844
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CD; ACUG; BLAU; IBD1; Nlrc2; Card15; F830032C23Rik
    Orthologs
    Location:
    8; 8 C3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (88647280..88688474)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (91171246..91212373)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene naked cuticle 1 homolog (Drosophila) Neighboring gene sorting nexin 20 Neighboring gene CYLD lysine 63 deubiquitinase Neighboring gene ribosomal protein S7 pseudogene Neighboring gene nucleophosmin 1 pseudogene

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    CARD domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    Hsp70 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Hsp90 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    endodeoxyribonuclease activity, producing 5'-phosphomonoesters IEA
    Inferred from Electronic Annotation
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    muramyl dipeptide binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    muramyl dipeptide binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    peptidoglycan binding ISO
    Inferred from Sequence Orthology
    more info
     
    peptidoglycan binding TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    activation of MAPK activity involved in innate immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    activation of immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to muramyl dipeptide ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to peptidoglycan IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytokine production involved in immune response ISO
    Inferred from Sequence Orthology
    more info
     
    cytokine secretion involved in immune response ISO
    Inferred from Sequence Orthology
    more info
     
    defense response TAS
    Traceable Author Statement
    more info
    PubMed 
    defense response to Gram-positive bacterium IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    defense response to Gram-positive bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    detection of bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    detection of biotic stimulus TAS
    Traceable Author Statement
    more info
    PubMed 
    detection of muramyl dipeptide ISO
    Inferred from Sequence Orthology
    more info
     
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    immunoglobulin production involved in immunoglobulin mediated immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    inflammatory response TAS
    Traceable Author Statement
    more info
    PubMed 
    innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    innate immune response in mucosa IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    macrophage inflammatory protein-1 alpha production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    maintenance of gastrointestinal epithelium ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of T cell mediated immunity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of growth of symbiont in host IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of inflammatory response to antigenic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of interferon-gamma production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of interleukin-12 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of interleukin-12 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of interleukin-18 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of interleukin-2 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of macrophage apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of toll-like receptor 2 signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of tumor necrosis factor production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nucleotide-binding oligomerization domain containing 2 signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nucleotide-binding oligomerization domain containing 2 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of B cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of JNK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of NIK/NF-kappaB signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of NIK/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of Notch signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of antibacterial peptide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cytokine production involved in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of dendritic cell antigen processing and presentation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of dendritic cell cytokine production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of humoral immune response mediated by circulating immunoglobulin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interleukin-1 beta production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-1 beta secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of interleukin-1 beta secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-10 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interleukin-12 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of interleukin-12 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interleukin-17 production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-6 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of interleukin-6 production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of interleukin-6 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-8 production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of monocyte chemotactic protein-1 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of nitric-oxide synthase biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of oxidoreductase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of peptidyl-tyrosine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of phosphatidylinositol 3-kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of prostaglandin-E synthase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of prostaglandin-endoperoxide synthase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of stress-activated MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of stress-activated MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of tumor necrosis factor production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of tumor necrosis factor production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of tumor necrosis factor production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of type 2 immune response ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of xenophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein oligomerization TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of neutrophil chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to exogenous dsRNA IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to muramyl dipeptide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to muramyl dipeptide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to muramyl dipeptide ISO
    Inferred from Sequence Orthology
    more info
     
    response to peptidoglycan IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to peptidoglycan IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with COP9 signalosome ISO
    Inferred from Sequence Orthology
    more info
     
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    nucleotide-binding oligomerization domain-containing protein 2
    Names
    caspase recruitment domain family, member 15
    caspase recruitment domain-containing protein 15

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145857.2NP_665856.2  nucleotide-binding oligomerization domain-containing protein 2

      See identical proteins and their annotated locations for NP_665856.2

      Status: VALIDATED

      Source sequence(s)
      AC156937
      Consensus CDS
      CCDS52632.1
      UniProtKB/TrEMBL
      Q80SY9
      Related
      ENSMUSP00000113773, OTTMUSP00000038424, ENSMUST00000118370, OTTMUST00000074061
      Conserved Domains (4) summary
      cd00116
      Location:753980
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:768789
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:266436
      NACHT; NACHT domain
      cl14633
      Location:107186
      DD; Death Domain Superfamily of protein-protein interaction domains

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      88647280..88688474
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248390.1XP_011246692.1  nucleotide-binding oligomerization domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011246692.1

      Conserved Domains (4) summary
      cd00116
      Location:753981
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:768789
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:266436
      NACHT; NACHT domain
      cl14633
      Location:107186
      DD; Death Domain Superfamily of protein-protein interaction domains
    2. XM_006531029.3XP_006531092.1  nucleotide-binding oligomerization domain-containing protein 2 isoform X2

      Conserved Domains (4) summary
      cd00116
      Location:753934
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:762780
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:266436
      NACHT; NACHT domain
      cl14633
      Location:107186
      DD; Death Domain Superfamily of protein-protein interaction domains
    3. XM_006531028.2XP_006531091.1  nucleotide-binding oligomerization domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006531091.1

      Conserved Domains (4) summary
      cd00116
      Location:753981
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:768789
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:266436
      NACHT; NACHT domain
      cl14633
      Location:107186
      DD; Death Domain Superfamily of protein-protein interaction domains
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