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    TRIB2 tribbles pseudokinase 2 [ Homo sapiens (human) ]

    Gene ID: 28951, updated on 12-Mar-2017
    Official Symbol
    TRIB2provided by HGNC
    Official Full Name
    tribbles pseudokinase 2provided by HGNC
    Primary source
    HGNC:HGNC:30809
    See related
    Ensembl:ENSG00000071575 MIM:609462; Vega:OTTHUMG00000090575
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C5FW; TRB2; GS3955
    Summary
    This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]
    Orthologs
    Location:
    2p24.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 2 NC_000002.12 (12716872..12742734)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (12856998..12882860)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene MIR3681 host gene Neighboring gene uncharacterized LOC105373431 Neighboring gene uncharacterized LOC107985853 Neighboring gene microRNA 3125 Neighboring gene uncharacterized LOC100506474 Neighboring gene uncharacterized LOC105373436 Neighboring gene uncharacterized LOC105373484

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association of pericardial fat identifies a unique locus for ectopic fat.
    NHGRI GWA Catalog
    GWAS of dental caries patterns in the permanent dentition.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ57420

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    mitogen-activated protein kinase kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    NOT nucleotide binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein kinase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    ubiquitin protein ligase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    ubiquitin-protein transferase regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Process Evidence Code Pubs
    negative regulation of fat cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    negative regulation of interleukin-10 biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein kinase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    NOT protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of MAP kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of MAP kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    tribbles homolog 2
    Names
    TRIB2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011644.1 RefSeqGene

      Range
      5001..30863
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_021643.3NP_067675.1  tribbles homolog 2

      See identical proteins and their annotated locations for NP_067675.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes a functional protein.
      Source sequence(s)
      AC009486, AY245544, DC379987
      Consensus CDS
      CCDS1683.1
      UniProtKB/Swiss-Prot
      Q92519
      Related
      ENSP00000155926, OTTHUMP00000115687, ENST00000155926, OTTHUMT00000207114
      Conserved Domains (2) summary
      smart00220
      Location:64308
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14022
      Location:67308
      PK_TRB2; Pseudokinase domain of Tribbles Homolog 2

    RNA

    1. NR_027303.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site and lacks the translational start codon used in variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC009486, AK129973, AK299146, AY245544, D87119, DC379987
      Related
      ENST00000381465, OTTHUMT00000280497

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p7 Primary Assembly

      Range
      12716872..12742734
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018913.2 Alternate CHM1_1.1

      Range
      12786401..12812238
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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