Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    DCLK1 doublecortin like kinase 1 [ Homo sapiens (human) ]

    Gene ID: 9201, updated on 22-Apr-2017
    Official Symbol
    DCLK1provided by HGNC
    Official Full Name
    doublecortin like kinase 1provided by HGNC
    Primary source
    HGNC:HGNC:2700
    See related
    Ensembl:ENSG00000133083 MIM:604742; Vega:OTTHUMG00000016729
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CL1; DCLK; CLICK1; DCDC3A; DCAMKL1
    Summary
    This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.[provided by RefSeq, Sep 2010]
    Orthologs
    Location:
    13q13.3
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 13 NC_000013.11 (35768652..36132020, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (36342789..36705514, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370161 Neighboring gene long intergenic non-protein coding RNA 445 Neighboring gene uncharacterized LOC105370163 Neighboring gene nuclear-encoded mitochondrial transfer RNA-Gln (TTG) 10-1 Neighboring gene CCDC169-SOHLH2 readthrough Neighboring gene uncharacterized LOC107984604 Neighboring gene spermatogenesis and oogenesis specific basic helix-loop-helix 2

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A genome-wide association study of optic disc parameters.
    NHGRI GWA Catalog
    Genetic variants associated with breast size also influence breast cancer risk.
    NHGRI GWA Catalog
    Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study.
    NHGRI GWA Catalog
    Genome-wide association study of the age of onset of childhood asthma.
    NHGRI GWA Catalog
    Genome-wide scan revealed that polymorphisms in the PNPLA3, SAMM50, and PARVB genes are associated with development and progression of nonalcoholic fatty liver disease in Japan.
    NHGRI GWA Catalog
    Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry.
    NHGRI GWA Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • KIAA0369

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    signal transducer activity, downstream of receptor TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    axon extension IEA
    Inferred from Electronic Annotation
    more info
     
    central nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    central nervous system projection neuron axonogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    dendrite morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    endosomal transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    forebrain development IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of protein localization to nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    neuron migration IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    peptidyl-threonine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein phosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    response to virus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    intracellular IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    serine/threonine-protein kinase DCLK1
    Names
    doublecortin domain-containing protein 3A
    doublecortin-like and CAM kinase-like 1
    NP_001182344.1
    NP_001182345.1
    NP_001182359.1
    NP_004725.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195415.1NP_001182344.1  serine/threonine-protein kinase DCLK1 isoform 2

      See identical proteins and their annotated locations for NP_001182344.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also known as DCLK-short-B, DCK-beta1 or KIAA0369-BS) is produced from the 3' promoter. It lacks several 5' exons but has an alternate 5' exon, as compared to variant 1. The resulting isoform (2) has a shorter and different N-terminus, and lacks doublecortin domains, as compared to isoform 1.
      Source sequence(s)
      AK295777, AK311195, AL139083, AL157760
      Consensus CDS
      CCDS73561.1
      UniProtKB/Swiss-Prot
      O15075
      Related
      ENSP00000484452.1, ENST00000615680.4
      Conserved Domains (2) summary
      smart00220
      Location:83340
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14183
      Location:76343
      STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
    2. NM_001195416.1NP_001182345.1  serine/threonine-protein kinase DCLK1 isoform 3

      See identical proteins and their annotated locations for NP_001182345.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant [3, also known as DCLK-short-A, DCK-beta2, KIAA0369-BL or cpg16 (candidate plasticity gene 16)] is produced from the 3' promoter. It lacks several 5' exons but has an alternate 5' exon, and lacks a coding exon in the 3' region that results in a frame-shift, as compared to variant 1. The resulting isoform (3) has a shorter and different N-terminus and a longer and distinct C-terminus, and lacks doublecortin domains, as compared to isoform 1.
      Source sequence(s)
      AK299059, AK311195, AL139083, AL157760, BC152456
      Consensus CDS
      CCDS55895.1
      UniProtKB/Swiss-Prot
      O15075
      UniProtKB/TrEMBL
      B7Z5K4
      Related
      ENSP00000369223.1, OTTHUMP00000018252, ENST00000379893.5, OTTHUMT00000044488
      Conserved Domains (2) summary
      smart00220
      Location:83340
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14183
      Location:76343
      STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
    3. NM_001195430.1NP_001182359.1  serine/threonine-protein kinase DCLK1 isoform 4

      See identical proteins and their annotated locations for NP_001182359.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) is produced from the 3' promoter. It shares only one exon with variant 1, and encodes a 56 aa long isoform [4, also known as ania-4, or CARP (CaMK-related peptide)], which mainly consists of the serine/proline-rich domain.
      Source sequence(s)
      AK311195, AL157760, BM682165
    4. NM_001330071.1NP_001317000.1  serine/threonine-protein kinase DCLK1 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an alternate exon in the 3' coding region, resulting in a frameshift compared to variant 1. Both variants 5 and 6 encode the same isoform (5), which is longer and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK295777, AL139083, AL157760, BC152456, BM679448, DB453639, DC350316, HY138649
      Consensus CDS
      CCDS81762.1
      UniProtKB/Swiss-Prot
      O15075
    5. NM_001330072.1NP_001317001.1  serine/threonine-protein kinase DCLK1 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and lacks an alternate exon in the 3' coding region, resulting in a frameshift compared to variant 1. Both variants 5 and 6 encode the same isoform (5), which is longer and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK295777, AL139083, AL157760, AL160392, BC152456, BM679448, DA154341, DC350316
      Consensus CDS
      CCDS81762.1
      UniProtKB/Swiss-Prot
      O15075
    6. NM_004734.4NP_004725.1  serine/threonine-protein kinase DCLK1 isoform 1

      See identical proteins and their annotated locations for NP_004725.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also known as DCLK-long-B, DCK-alpha1 or KIAA0369AS) is produced from the 5' promoter. It encodes the isoform 1, which includes two doublecortin domains, a serine/proline-rich domain and a protein kinase domain.
      Source sequence(s)
      AK295777, AL139083, AL157760, AL160392, BC152456
      Consensus CDS
      CCDS9354.1
      UniProtKB/Swiss-Prot
      O15075
      Related
      ENSP00000255448.4, OTTHUMP00000018250, ENST00000255448.8, OTTHUMT00000044483
      Conserved Domains (3) summary
      smart00220
      Location:390647
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00537
      Location:52142
      DCX; Domain in the Doublecortin (DCX) gene product
      cd14183
      Location:383650
      STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p7 Primary Assembly

      Range
      35768652..36132020 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006719893.2XP_006719956.1  serine/threonine-protein kinase DCLK1 isoform X1

      Conserved Domains (3) summary
      smart00220
      Location:390647
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00537
      Location:52142
      DCX; Domain in the Doublecortin (DCX) gene product
      cd14183
      Location:383650
      STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
    2. XM_005266592.2XP_005266649.1  serine/threonine-protein kinase DCLK1 isoform X1

      Related
      ENSP00000353846.3, OTTHUMP00000018251, ENST00000360631.7, OTTHUMT00000044487
      Conserved Domains (3) summary
      smart00220
      Location:390647
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00537
      Location:52142
      DCX; Domain in the Doublecortin (DCX) gene product
      cd14183
      Location:383650
      STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
    3. XM_017020847.1XP_016876336.1  serine/threonine-protein kinase DCLK1 isoform X2

    4. XM_017020848.1XP_016876337.1  serine/threonine-protein kinase DCLK1 isoform X3

      UniProtKB/TrEMBL
      Q5VZY9
      Related
      ENSP00000369222.4, OTTHUMP00000018248, ENST00000379892.4, OTTHUMT00000044478
      Conserved Domains (1) summary
      smart00537
      Location:52142
      DCX; Domain in the Doublecortin (DCX) gene product

    Alternate CHM1_1.1

    Genomic

    1. NC_018924.2 Alternate CHM1_1.1

      Range
      36310364..36673089 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center