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    Vip vasoactive intestinal polypeptide [ Mus musculus (house mouse) ]

    Gene ID: 22353, updated on 25-May-2017
    Official Symbol
    Vipprovided by MGI
    Official Full Name
    vasoactive intestinal polypeptideprovided by MGI
    Primary source
    MGI:MGI:98933
    See related
    Ensembl:ENSMUSG00000019772 Vega:OTTMUSG00000063563
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    This gene encodes a neuropeptide of the glucagon/secretin superfamily with potent bronchodilator, immunomodulator and anti-inflammatory properties. The encoded protein is proteolytically processed to generate two structurally similar neuropeptides - vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI). In the digestive tract, VIP stimulates relaxation of enteric smooth muscle, secretion of water and electrolytes, release of insulin and glucagon, and inhibition of gastric acid secretion. In the cardiovascular system, VIP causes coronary vasodilation and stimulates contractility in the heart. Mice lacking VIP exhibit airway hyperresponsiveness and airway inflammation. Male mice lacking VIP exhibit moderate pulmonary arterial hypertension resulting in increased mortality. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
    Orthologs
    Location:
    10; 10 A1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (5639193..5647617)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (4698927..4707323, complement)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene spectrin repeat containing, nuclear envelope 1 Neighboring gene predicted gene, 40594 Neighboring gene myc target 1 Neighboring gene predicted gene, 40595 Neighboring gene predicted gene, 30617

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Clone Names

    • MGC107202

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    hormone activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hormone activity ISO
    Inferred from Sequence Orthology
    more info
     
    receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    learning or memory ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of blood vessel diameter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of penile erection ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    VIP peptides
    Names
    PHI, peptide histidine isoleucine

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313969.1NP_001300898.1  VIP peptides isoform 2 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
      Source sequence(s)
      AK018599, BE990430
      UniProtKB/Swiss-Prot
      P32648
      Conserved Domains (1) summary
      pfam00123
      Location:82108
      Hormone_2; Peptide hormone
    2. NM_011702.3NP_035832.1  VIP peptides isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_035832.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK018599, BE990430
      Consensus CDS
      CCDS56682.1
      UniProtKB/Swiss-Prot
      P32648
      UniProtKB/TrEMBL
      A0A0R4J003
      Related
      ENSMUSP00000019906.4, OTTMUSP00000079997, ENSMUST00000019906.5, OTTMUST00000154818
      Conserved Domains (1) summary
      pfam00123
      Location:82108
      Hormone_2; Peptide hormone

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      5639193..5647617
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512446.1XP_006512509.1  VIP peptides isoform X1

      Conserved Domains (1) summary
      pfam00123
      Location:82108
      Hormone_2; Peptide hormone
    2. XM_006512447.1XP_006512510.1  VIP peptides isoform X2

      See identical proteins and their annotated locations for XP_006512510.1

      UniProtKB/Swiss-Prot
      P32648
      Conserved Domains (1) summary
      pfam00123
      Location:81107
      Hormone_2; Peptide hormone
    3. XM_006512448.1XP_006512511.1  VIP peptides isoform X3

      Conserved Domains (1) summary
      pfam00123
      Location:81107
      Hormone_2; Peptide hormone
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