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    Dcn decorin [ Mus musculus (house mouse) ]

    Gene ID: 13179, updated on 22-May-2018
    Official Symbol
    Dcnprovided by MGI
    Official Full Name
    decorinprovided by MGI
    Primary source
    MGI:MGI:94872
    See related
    Ensembl:ENSMUSG00000019929
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DC; PG40; PGII; PGS2; DSPG2; SLRR1B
    Summary
    This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded preproprotein is proteolytically processed to generate a mature protein product, which is secreted into the extracellular space to regulate collagen fibril assembly. Homozygous knockout mice for this gene exhibit enhanced tumorigenesis in a liver cancer model, and defects in collagen fibrils, leading to weakened skin and tendons. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
    Expression
    Biased expression in bladder adult (RPKM 1095.0), subcutaneous fat pad adult (RPKM 305.9) and 7 other tissues See more
    Orthologs
    See Dcn in Genome Data Viewer
    Location:
    10 C3; 10 50.27 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (97479500..97518163)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (96942134..96980796)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene CWC15 homolog pseudogene Neighboring gene predicted gene, 34114 Neighboring gene microRNA 3966 Neighboring gene RIKEN cDNA 4930473O22 gene Neighboring gene lumican

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    collagen binding ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular matrix binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glycosaminoglycan binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein N-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    collagen type VI trimer ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space HDA PubMed 
    Preferred Names
    decorin
    Names
    bone proteoglycan II

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190451.2NP_001177380.1  decorin preproprotein

      See identical proteins and their annotated locations for NP_001177380.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC159710, AK145905, BG088078, BM114383
      Consensus CDS
      CCDS24141.1
      UniProtKB/Swiss-Prot
      P28654
      UniProtKB/TrEMBL
      Q3UKR1
      Related
      ENSMUSP00000100924.3, ENSMUST00000105287.10
      Conserved Domains (4) summary
      smart00013
      Location:4880
      LRRNT; Leucine rich repeat N-terminal domain
      cd00116
      Location:79285
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:5777
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:79136
      LRR_8; Leucine rich repeat
    2. NM_007833.6NP_031859.1  decorin preproprotein

      See identical proteins and their annotated locations for NP_031859.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AA881173, AC159710, BB575065, BM114383, CK623125, DV056002, W62675
      Consensus CDS
      CCDS24141.1
      UniProtKB/Swiss-Prot
      P28654
      UniProtKB/TrEMBL
      Q3UKR1
      Related
      ENSMUSP00000131431.2, ENSMUST00000163448.3
      Conserved Domains (4) summary
      smart00013
      Location:4880
      LRRNT; Leucine rich repeat N-terminal domain
      cd00116
      Location:79285
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:5777
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:79136
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      97479500..97518163
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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