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    Tlr3 toll-like receptor 3 [ Mus musculus (house mouse) ]

    Gene ID: 142980, updated on 19-Aug-2017
    Official Symbol
    Tlr3provided by MGI
    Official Full Name
    toll-like receptor 3provided by MGI
    Primary source
    MGI:MGI:2156367
    See related
    Ensembl:ENSMUSG00000031639 Vega:OTTMUSG00000061136
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI957183
    Orthologs
    Location:
    8; 8 B1.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (45395665..45411949, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (46481019..46495893, complement)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 30504 Neighboring gene cytochrome P450, family 4, subfamily v, polypeptide 3 Neighboring gene family with sequence similarity 149, member A Neighboring gene sorbin and SH3 domain containing 2 Neighboring gene predicted gene, 30759 Neighboring gene predicted gene 16351

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Chemically induced (ENU) (1) 
    • Hepatitis B, organism-specific biosystem (from KEGG)
      Hepatitis B, organism-specific biosystemHepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and...
    • Hepatitis C, organism-specific biosystem (from KEGG)
      Hepatitis C, organism-specific biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • Hepatitis C, conserved biosystem (from KEGG)
      Hepatitis C, conserved biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
      Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Influenza A, organism-specific biosystem (from KEGG)
      Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Influenza A, conserved biosystem (from KEGG)
      Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Toll Like Receptor signaling, organism-specific biosystem (from WikiPathways)
      Toll Like Receptor signaling, organism-specific biosystemToll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system. They are single, membrane-spanning, non-catalytic receptors usually expressed in sentinel cells su...
    • Toll-Like Receptors Cascades, organism-specific biosystem (from REACTOME)
      Toll-Like Receptors Cascades, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Toll-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Toll-like receptor signaling pathway, conserved biosystem (from KEGG)
      Toll-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Trafficking and processing of endosomal TLR, organism-specific biosystem (from REACTOME)
      Trafficking and processing of endosomal TLR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    I-kappaB phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    MyD88-independent toll-like receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to exogenous dsRNA ISO
    Inferred from Sequence Orthology
    more info
     
    defense response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    defense response to virus IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    defense response to virus TAS
    Traceable Author Statement
    more info
    PubMed 
    extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    microglial cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    microglial cell activation involved in immune response ISO
    Inferred from Sequence Orthology
    more info
     
    necroptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of I-kappaB kinase/NF-kappaB signaling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of JNK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of NF-kappaB import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of chemokine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of chemokine production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cytokine production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interferon-alpha biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interferon-beta biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interferon-beta biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    positive regulation of interferon-beta production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of interferon-gamma biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-12 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of interleukin-6 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of interleukin-6 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-8 production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of toll-like receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of tumor necrosis factor production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of tumor necrosis factor production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of type I interferon production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of type III interferon production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of dendritic cell cytokine production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to dsRNA ISO
    Inferred from Sequence Orthology
    more info
     
    response to exogenous dsRNA IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to exogenous dsRNA ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    toll-like receptor 3 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    toll-like receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    toll-like receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    endosome IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    intracellular ISO
    Inferred from Sequence Orthology
    more info
     
    lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_126166.4NP_569054.2  toll-like receptor 3 precursor

      See identical proteins and their annotated locations for NP_569054.2

      Status: PROVISIONAL

      Source sequence(s)
      AC116861, AC120003
      Consensus CDS
      CCDS22278.1
      UniProtKB/Swiss-Prot
      Q99MB1
      Related
      ENSMUSP00000034056.4, OTTMUSP00000077473, ENSMUST00000034056.11, OTTMUST00000149295
      Conserved Domains (7) summary
      smart00082
      Location:646698
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:756901
      TIR; Toll - interleukin 1 - resistance
      cd00116
      Location:100319
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:589610
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:277300
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:508546
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:275330
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      45395665..45411949 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509279.2XP_006509342.1  toll-like receptor 3 isoform X1

      See identical proteins and their annotated locations for XP_006509342.1

      UniProtKB/Swiss-Prot
      Q99MB1
      Conserved Domains (7) summary
      smart00082
      Location:646698
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:756901
      TIR; Toll - interleukin 1 - resistance
      cd00116
      Location:100319
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:589610
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:277300
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:508546
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:275330
      LRR_8; Leucine rich repeat
    2. XM_006509280.2XP_006509343.1  toll-like receptor 3 isoform X1

      See identical proteins and their annotated locations for XP_006509343.1

      UniProtKB/Swiss-Prot
      Q99MB1
      Conserved Domains (7) summary
      smart00082
      Location:646698
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:756901
      TIR; Toll - interleukin 1 - resistance
      cd00116
      Location:100319
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:589610
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:277300
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:508546
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:275330
      LRR_8; Leucine rich repeat
    3. XM_006509282.3XP_006509345.1  toll-like receptor 3 isoform X1

      See identical proteins and their annotated locations for XP_006509345.1

      UniProtKB/Swiss-Prot
      Q99MB1
      Related
      ENSMUSP00000147738.1, OTTMUSP00000077476, ENSMUST00000209772.1, OTTMUST00000149298
      Conserved Domains (7) summary
      smart00082
      Location:646698
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:756901
      TIR; Toll - interleukin 1 - resistance
      cd00116
      Location:100319
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:589610
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:277300
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:508546
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:275330
      LRR_8; Leucine rich repeat
    4. XM_006509281.3XP_006509344.1  toll-like receptor 3 isoform X1

      See identical proteins and their annotated locations for XP_006509344.1

      UniProtKB/Swiss-Prot
      Q99MB1
      Conserved Domains (7) summary
      smart00082
      Location:646698
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:756901
      TIR; Toll - interleukin 1 - resistance
      cd00116
      Location:100319
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:589610
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:277300
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:508546
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:275330
      LRR_8; Leucine rich repeat
    5. XM_006509283.3XP_006509346.1  toll-like receptor 3 isoform X1

      See identical proteins and their annotated locations for XP_006509346.1

      UniProtKB/Swiss-Prot
      Q99MB1
      Conserved Domains (7) summary
      smart00082
      Location:646698
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:756901
      TIR; Toll - interleukin 1 - resistance
      cd00116
      Location:100319
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:589610
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:277300
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:508546
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:275330
      LRR_8; Leucine rich repeat
    6. XM_006509278.3XP_006509341.1  toll-like receptor 3 isoform X1

      See identical proteins and their annotated locations for XP_006509341.1

      UniProtKB/Swiss-Prot
      Q99MB1
      Conserved Domains (7) summary
      smart00082
      Location:646698
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:756901
      TIR; Toll - interleukin 1 - resistance
      cd00116
      Location:100319
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:589610
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:277300
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:508546
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:275330
      LRR_8; Leucine rich repeat
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