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    CALCA calcitonin related polypeptide alpha [ Homo sapiens (human) ]

    Gene ID: 796, updated on 9-Apr-2017
    Official Symbol
    CALCAprovided by HGNC
    Official Full Name
    calcitonin related polypeptide alphaprovided by HGNC
    Primary source
    HGNC:HGNC:1437
    See related
    Ensembl:ENSG00000110680 MIM:114130; Vega:OTTHUMG00000159731
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT; KC; PCT; CGRP; CALC1; CGRP1; CGRP-I
    Summary
    This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014]
    Orthologs
    Location:
    11p15.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 11 NC_000011.10 (14966668..14972361, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (14988214..14993879, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984314 Neighboring gene cytochrome P450 family 2 subfamily R member 1 Neighboring gene calcitonin pseudogene Neighboring gene olfactory receptor family 7 subfamily E member 41 pseudogene Neighboring gene calcitonin related polypeptide beta

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association study of vitamin D levels in children: replication in the Western Australian Pregnancy Cohort (Raine) study.
    NHGRI GWA Catalog
    • Amyloid fiber formation, organism-specific biosystem (from REACTOME)
      Amyloid fiber formation, organism-specific biosystemAmyloid is a term used to describe deposits of fibrillar proteins, typically extracellular. The abnormal accumulation of amyloid, amyloidosis, is a term associated with tissue damage caused by amyloi...
    • Calcitonin-like ligand receptors, organism-specific biosystem (from REACTOME)
      Calcitonin-like ligand receptors, organism-specific biosystemThe calcitonin peptide family comprises calcitonin, amylin, calcitonin gene-related peptide (CGRP), adrenomedullin (AM) and intermedin (AM2). Calcitonin is a 32 amino acid peptide, involved in bone h...
    • Class B/2 (Secretin family receptors), organism-specific biosystem (from REACTOME)
      Class B/2 (Secretin family receptors), organism-specific biosystemThis family is known as Family B (secretin-receptor family, family 2) G-protein-coupled receptors. Family B GPCRs include secretin, calcitonin, parathyroid hormone/parathyroid hormone-related peptide...
    • Endothelin Pathways, organism-specific biosystem (from WikiPathways)
      Endothelin Pathways, organism-specific biosystemEndothelin-1 is a bicyclic 21 amino acid peptide, produced primarily in the endothelium. It is a potent stimulus of long-lasting and persistent vasoconstriction. It also has a role as a stimulus of i...
    • G alpha (s) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (s) signalling events, organism-specific biosystemThe general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to col...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • GPCR ligand binding, organism-specific biosystem (from REACTOME)
      GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
    • Lung fibrosis, organism-specific biosystem (from WikiPathways)
      Lung fibrosis, organism-specific biosystemLung fibrosis pathway linked to events (molecular initiating event, key events and associative events) in a putative Adverse Outcome Pathway for lung fibrosis.
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
      Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Clone Names

    • MGC126648

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calcitonin receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    hormone activity IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    activation of adenylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
     
    activation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    aging IEA
    Inferred from Electronic Annotation
    more info
     
    artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    cellular protein metabolic process TAS
    Traceable Author Statement
    more info
     
    cellular response to nerve growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to tumor necrosis factor IEA
    Inferred from Electronic Annotation
    more info
     
    detection of temperature stimulus involved in sensory perception of pain IEA
    Inferred from Electronic Annotation
    more info
     
    embryo implantation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    feeding behavior IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    monocyte chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of bone resorption IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of neurological system process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of ossification IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of adenylate cyclase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of ossification IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of heart rate IEA
    Inferred from Electronic Annotation
    more info
     
    response to heat IEA
    Inferred from Electronic Annotation
    more info
     
    response to pain IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    terminal bouton IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    calcitonin; calcitonin gene-related peptide 1
    Names
    alpha-type CGRP
    calcitonin 1
    calcitonin gene-related peptide I
    calcitonin/calcitonin-related polypeptide, alpha
    katacalcin

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_015960.1 RefSeqGene

      Range
      5001..10618
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_13

    mRNA and Protein(s)

    1. NM_001033952.2NP_001029124.1  calcitonin isoform CT preproprotein

      See identical proteins and their annotated locations for NP_001029124.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate 3' coding region and 3' UTR compared to variant 3. The resulting protein has a longer and distinct C-terminus compared to calcitonin gene-related peptide 1. Variants 1 and 2 encode the same protein, which is cleaved to yield calcitonin (CT), a thyroid peptide-hormone product, and katacalcin peptides.
      Source sequence(s)
      AC090835, BF942024, M26095
      Consensus CDS
      CCDS7819.1
      UniProtKB/Swiss-Prot
      P01258
      Related
      ENSP00000379657.2, OTTHUMP00000216320, ENST00000396372.2, OTTHUMT00000357067
      Conserved Domains (2) summary
      smart00113
      Location:83120
      CALCITONIN; calcitonin
      pfam00214
      Location:1121
      Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family
    2. NM_001033953.2NP_001029125.1  calcitonin gene-related peptide 1 isoform alpha-CGRP preproprotein

      See identical proteins and their annotated locations for NP_001029125.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) represents the longest coding transcript and encodes the shorter protein, which is cleaved to yield calcitonin gene-related peptide 1 (alpha-CGRP). Alpha-CGRP functions both as an antimicrobial peptide and a vasodilator.
      Source sequence(s)
      AC090835, CD612754, FO082042
      Consensus CDS
      CCDS31432.1
      UniProtKB/Swiss-Prot
      P06881
      Related
      ENSP00000354286.3, ENST00000361010.7
      Conserved Domains (2) summary
      smart00113
      Location:81123
      CALCITONIN; calcitonin
      pfam00214
      Location:1124
      Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family
    3. NM_001741.2NP_001732.1  calcitonin isoform CT preproprotein

      See identical proteins and their annotated locations for NP_001732.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' and 3' UTRs and the coding region compared to variant 3. The resulting protein has a longer and distinct C-terminus compared to calcitonin gene-related peptide 1. Variants 1 and 2 encode the same protein, which is cleaved to yield calcitonin (CT), a thyroid peptide-hormone product, and katacalcin peptides.
      Source sequence(s)
      BC069704, BF942024
      Consensus CDS
      CCDS7819.1
      UniProtKB/Swiss-Prot
      P01258
      Related
      ENSP00000331746.4, OTTHUMP00000216318, ENST00000331587.8, OTTHUMT00000357065
      Conserved Domains (2) summary
      smart00113
      Location:83120
      CALCITONIN; calcitonin
      pfam00214
      Location:1121
      Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family

    RNA

    1. NR_125898.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BC069684, BX094781, CB048118, M64486

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p7 Primary Assembly

      Range
      14966668..14972361 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017018283.1XP_016873772.1  calcitonin isoform X1

      UniProtKB/Swiss-Prot
      P01258
      Related
      ENSP00000420618.1, OTTHUMP00000216319, ENST00000469608.5, OTTHUMT00000357066
      Conserved Domains (2) summary
      smart00113
      Location:83120
      CALCITONIN; calcitonin
      pfam00214
      Location:1121
      Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family
    2. XM_017018284.1XP_016873773.1  calcitonin isoform X1

      UniProtKB/Swiss-Prot
      P01258
      Conserved Domains (2) summary
      smart00113
      Location:83120
      CALCITONIN; calcitonin
      pfam00214
      Location:1121
      Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family

    Alternate CHM1_1.1

    Genomic

    1. NC_018922.2 Alternate CHM1_1.1

      Range
      14987226..14992843 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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