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    CHI3L1 chitinase 3 like 1 [ Homo sapiens (human) ]

    Gene ID: 1116, updated on 25-May-2017
    Official Symbol
    CHI3L1provided by HGNC
    Official Full Name
    chitinase 3 like 1provided by HGNC
    Primary source
    HGNC:HGNC:1932
    See related
    Ensembl:ENSG00000133048 MIM:601525; Vega:OTTHUMG00000042122
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GP39; ASRT7; GP-39; YKL40; CGP-39; YKL-40; YYL-40; HC-gp39; HCGP-3P; hCGP-39
    Summary
    Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling. [provided by RefSeq, Sep 2009]
    Orthologs
    Location:
    1q32.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 1 NC_000001.11 (203178931..203186794, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (203148059..203155978, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene adenosine A1 receptor Neighboring gene myosin binding protein H Neighboring gene chitinase 1 Neighboring gene nucleophosmin 1 pseudogene 40

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Asthma-related traits, susceptibility to, 7
    MedGen: C2677770 OMIM: 611960 GeneReviews: Not available
    Compare labs
    Schizophrenia
    MedGen: C0036341 OMIM: 181500 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.
    NHGRI GWA Catalog
    Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of chitinase 3-like 1 (CHI3L1, cartilage glycoprotein-39) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
      Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ38139, DKFZp686N19119

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    chitin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT chitinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular matrix structural constituent NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    activation of NF-kappaB-inducing kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    cartilage development NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cellular response to interleukin-1 IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to tumor necrosis factor ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    inflammatory response IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    interleukin-8 secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lung development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neutrophil degranulation TAS
    Traceable Author Statement
    more info
     
    positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of peptidyl-threonine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of protein kinase B signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to interleukin-1 IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to interleukin-6 IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to tumor necrosis factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    proteinaceous extracellular matrix NAS
    Non-traceable Author Statement
    more info
    PubMed 
    specific granule lumen TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    chitinase-3-like protein 1
    Names
    39 kDa synovial protein
    cartilage glycoprotein 39
    chitinase 3-like 1 (cartilage glycoprotein-39)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013056.1 RefSeqGene

      Range
      5001..12864
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001276.2NP_001267.2  chitinase-3-like protein 1 precursor

      See identical proteins and their annotated locations for NP_001267.2

      Status: REVIEWED

      Source sequence(s)
      AK225266, BC008568, DA167112
      Consensus CDS
      CCDS1435.1
      UniProtKB/Swiss-Prot
      P36222
      UniProtKB/TrEMBL
      A0A024R969
      Related
      ENSP00000255409.3, OTTHUMP00000039087, ENST00000255409.7, OTTHUMT00000100265
      Conserved Domains (2) summary
      cd02872
      Location:24380
      GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
      smart00636
      Location:23357
      Glyco_18; Glyco_18 domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p7 Primary Assembly

      Range
      203178931..203186794 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      204570380..204578243 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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