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    Tlr9 toll-like receptor 9 [ Mus musculus (house mouse) ]

    Gene ID: 81897, updated on 3-Dec-2016
    Official Symbol
    Tlr9provided by MGI
    Official Full Name
    toll-like receptor 9provided by MGI
    Primary source
    MGI:MGI:1932389
    See related
    Ensembl:ENSMUSG00000045322 Vega:OTTMUSG00000049422
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Orthologs
    Location:
    9; 9 F1
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (106222598..106226876)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (106124929..106129207)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1M Neighboring gene twinfilin actin binding protein 2 Neighboring gene aminolevulinic acid synthase 1 Neighboring gene uncharacterized LOC102636338

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    interleukin-1 receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    interleukin-1 receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    siRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    unmethylated CpG binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    I-kappaB phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    MyD88-dependent toll-like receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to chloroquine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    defense response to Gram-negative bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    defense response to virus IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    defense response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    maintenance of gastrointestinal epithelium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    microglial cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of calcium-transporting ATPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of interleukin-6 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of interleukin-8 production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of toll-like receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of JUN kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of NF-kappaB import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of chemokine production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of granulocyte macrophage colony-stimulating factor production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interferon-alpha biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interferon-beta biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interferon-beta production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of interferon-gamma biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-10 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of interleukin-12 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of interleukin-18 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of interleukin-6 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-8 production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of nitric-oxide synthase biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of toll-like receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of tumor necrosis factor production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of B cell activation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of cytokine secretion IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of dendritic cell cytokine production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to molecule of bacterial origin TAS
    Traceable Author Statement
    more info
    PubMed 
    response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    toll-like receptor 9 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    toll-like receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    toll-like receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    early phagosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031178.2NP_112455.2  toll-like receptor 9 precursor

      See identical proteins and their annotated locations for NP_112455.2

      Status: VALIDATED

      Source sequence(s)
      AC164430
      Consensus CDS
      CCDS40755.1
      UniProtKB/Swiss-Prot
      Q9EQU3
      Related
      ENSMUSP00000082207, OTTMUSP00000068182, ENSMUST00000062241, OTTMUST00000125992
      Conserved Domains (4) summary
      cd00116
      Location:194373
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:125168
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:497556
      LRR_8; Leucine rich repeat
      cl23749
      Location:870974
      TIR_2; TIR domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      106222598..106226876
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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