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    Lrp5 low density lipoprotein receptor-related protein 5 [ Mus musculus (house mouse) ]

    Gene ID: 16973, updated on 12-Mar-2017
    Official Symbol
    Lrp5provided by MGI
    Official Full Name
    low density lipoprotein receptor-related protein 5provided by MGI
    Primary source
    MGI:MGI:1278315
    See related
    Ensembl:ENSMUSG00000024913 Vega:OTTMUSG00000042195
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HBM; LR3; LRP7; OPPG; BMND1; mKIAA4142
    Orthologs
    Location:
    19; 19 A
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (3584825..3686564, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (3584825..3686564, complement)

    Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene protein phosphatase 6, regulatory subunit 3 Neighboring gene UTP3, small subunit processome component, homolog pseudogene Neighboring gene nuclear encoded tRNA alanine 9 (anticodon AGC) Neighboring gene RIKEN cDNA 1810055G02 gene Neighboring gene predicted gene, 36672 Neighboring gene predicted gene, 36608 Neighboring gene predicted gene, 36787

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Breast cancer, organism-specific biosystem (from KEGG)
      Breast cancer, organism-specific biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
    • Breast cancer, conserved biosystem (from KEGG)
      Breast cancer, conserved biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
    • Disassembly of the destruction complex and recruitment of AXIN to the membrane, organism-specific biosystem (from REACTOME)
      Disassembly of the destruction complex and recruitment of AXIN to the membrane, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • ESC Pluripotency Pathways, organism-specific biosystem (from WikiPathways)
      ESC Pluripotency Pathways, organism-specific biosystemThe cytokine LIF and its downstream effector STAT3 are essential for maintenance of pluripotency in mouse ES cells. The requirement for the transcription factor Oct3/4 for ES cell pluripotency is als...
    • MicroRNAs in Cardiomyocyte Hypertrophy, organism-specific biosystem (from WikiPathways)
      MicroRNAs in Cardiomyocyte Hypertrophy, organism-specific biosystemThis pathway shows the role of microRNAs in the process of cardiac hypertrophy. Converted from the humane pathway. MicroRNA targets were predicted by the TargetScan algorithm, and the predicted inter...
    • Nephronophthisis and Wnt Signaling, organism-specific biosystem (from WikiPathways)
      Nephronophthisis and Wnt Signaling, organism-specific biosystemThis pathway is modeled after Figure 5 of the article "Glomerulocystic kidney disease" (Bissler, et al. 2010). The gene product Wnt signals two different paths titled canonical and non-canonical. The...
    • PluriNetWork, organism-specific biosystem (from WikiPathways)
      PluriNetWork, organism-specific biosystemThe aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we inten...
    • Primary Focal Segmental Glomerulosclerosis FSGS, organism-specific biosystem (from WikiPathways)
      Primary Focal Segmental Glomerulosclerosis FSGS, organism-specific biosystemPrimary or idiopathic focal segmental glomerulosclerosis (FSGS) a cause of nephrotic syndrome in children and adolescents, as well as an important cause of end stage renal disease in adults. FSGS is ...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Signaling by Wnt, organism-specific biosystem (from REACTOME)
      Signaling by Wnt, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • TCF dependent signaling in response to WNT, organism-specific biosystem (from REACTOME)
      TCF dependent signaling in response to WNT, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Wnt Signaling Pathway NetPath, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway NetPath, organism-specific biosystemWnt family of proteins are a large family of cysteine-rich secreted glycoproteins that regulate cell-cell interactions. They bind to members of the Frizzled family of 7 transmembrane receptors. Bindi...
    • Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell pluri...
    • Wnt signaling pathway, organism-specific biosystem (from KEGG)
      Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt signaling pathway, conserved biosystem (from KEGG)
      Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • mTOR signaling pathway, organism-specific biosystem (from KEGG)
      mTOR signaling pathway, organism-specific biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...
    • mTOR signaling pathway, conserved biosystem (from KEGG)
      mTOR signaling pathway, conserved biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • KIAA4142

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    Wnt-activated receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Wnt-protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Wnt-protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    coreceptor activity involved in Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Wnt signaling pathway involved in dorsal/ventral axis specification IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Wnt signaling pathway involved in dorsal/ventral axis specification ISO
    Inferred from Sequence Orthology
    more info
     
    adipose tissue development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    adipose tissue development ISO
    Inferred from Sequence Orthology
    more info
     
    anatomical structure regression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    anterior/posterior pattern specification IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    apoptotic process involved in blood vessel morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    bone development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    bone marrow development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    bone marrow development ISO
    Inferred from Sequence Orthology
    more info
     
    bone morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    bone remodeling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    bone remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    branching involved in mammary gland duct morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    cell migration involved in gastrulation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cell-cell signaling involved in mammary gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cholesterol homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cholesterol homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    cholesterol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic digit morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular matrix-cell signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    gastrulation with mouth forming second IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    glucose catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    limb morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    mammary gland duct morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    osteoblast development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mesenchymal cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mitotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of osteoblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of sequence-specific DNA binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT positive regulation of skeletal muscle acetylcholine-gated channel clustering IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of bone remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of insulin secretion involved in cellular response to glucose stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    retina morphogenesis in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
     
    retina vasculature morphogenesis in camera-type eye IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    retina vasculature morphogenesis in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    retinal blood vessel morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    retinal blood vessel morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    somatic stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    low-density lipoprotein receptor-related protein 5
    Names
    LRP-5
    LRP-7
    low-density lipoprotein receptor-related protein 7

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008513.3NP_032539.2  low-density lipoprotein receptor-related protein 5 precursor

      See identical proteins and their annotated locations for NP_032539.2

      Status: VALIDATED

      Source sequence(s)
      AK081025, AK147330, BB070734
      Consensus CDS
      CCDS37881.1
      UniProtKB/Swiss-Prot
      Q91VN0
      Related
      ENSMUSP00000025856, OTTMUSP00000061850, ENSMUST00000025856, OTTMUST00000110769
      Conserved Domains (6) summary
      smart00135
      Location:407449
      LY; Low-density lipoprotein-receptor YWTD domain
      cd00112
      Location:12971331
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd05819
      Location:719755
      NHL; NHL repeat [structural motif]
      pfam00058
      Location:162202
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:298335
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl18310
      Location:684877
      NHL; NHL repeat unit of beta-propeller proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

      Range
      3584825..3686564 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_388250.1 RNA Sequence

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