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    Gcgr glucagon receptor [ Mus musculus (house mouse) ]

    Gene ID: 14527, updated on 8-Oct-2017
    Official Symbol
    Gcgrprovided by MGI
    Official Full Name
    glucagon receptorprovided by MGI
    Primary source
    MGI:MGI:99572
    See related
    Ensembl:ENSMUSG00000025127 Vega:OTTMUSG00000004269
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GR
    Orthologs
    Location:
    11; 11 E2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (120529186..120538989)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (120392041..120400298)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10 Neighboring gene predicted gene, 39490 Neighboring gene MAPK regulated corepressor interacting protein 1 Neighboring gene protein phosphatase 1, regulatory subunit 27

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    G-protein coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    glucagon receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glucagon receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    peptide hormone binding ISO
    Inferred from Sequence Orthology
    more info
     
    signal transducer activity IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    adenylate cyclase-activating G-protein coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    adenylate cyclase-modulating G-protein coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adenylate cyclase-modulating G-protein coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to glucagon stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to glucagon stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hormone-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of glycogen metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    endosome ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    glucagon receptor
    Names
    GL-R

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008101.2NP_032127.2  glucagon receptor precursor

      See identical proteins and their annotated locations for NP_032127.2

      Status: VALIDATED

      Source sequence(s)
      AK004890, AK144393, AV354937, BB869050
      Consensus CDS
      CCDS25739.1
      UniProtKB/Swiss-Prot
      Q61606
      UniProtKB/TrEMBL
      Q3UN81
      Related
      ENSMUSP00000026119.7, OTTMUSP00000004661, ENSMUST00000026119.7, OTTMUST00000009673
      Conserved Domains (2) summary
      pfam00002
      Location:139397
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02793
      Location:56125
      HRM; Hormone receptor domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      120529186..120538989
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314269.1XP_017169758.1  glucagon receptor isoform X5

    2. XM_017314267.1XP_017169756.1  glucagon receptor isoform X3

    3. XM_017314263.1XP_017169752.1  glucagon receptor isoform X1

    4. XM_017314265.1XP_017169754.1  glucagon receptor isoform X1

    5. XM_017314268.1XP_017169757.1  glucagon receptor isoform X4

    6. XM_017314266.1XP_017169755.1  glucagon receptor isoform X2

      UniProtKB/Swiss-Prot
      Q61606
      Conserved Domains (2) summary
      pfam00002
      Location:139397
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02793
      Location:56125
      HRM; Hormone receptor domain
    7. XM_017314264.1XP_017169753.1  glucagon receptor isoform X1

    8. XM_006532216.3XP_006532279.1  glucagon receptor isoform X6

      Conserved Domains (1) summary
      pfam00002
      Location:2260
      7tm_2; 7 transmembrane receptor (Secretin family)
    9. XM_006532217.2XP_006532280.1  glucagon receptor isoform X7

      Conserved Domains (1) summary
      cl21561
      Location:3176
      7tm_4; Olfactory receptor
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