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    RAP1 DNA-binding transcription factor RAP1 [ Saccharomyces cerevisiae S288c ]

    Gene ID: 855505, updated on 4-Sep-2016
    Gene symbol
    RAP1
    Gene description
    DNA-binding transcription factor RAP1
    Primary source
    SGD:S000005160
    Locus tag
    YNL216W
    Gene type
    protein coding
    RNA name
    DNA-binding transcription factor RAP1
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    GRF1; TBA1; TUF1
    See RAP1 in Map Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (241689..244172)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene ssDNA-dependent ATPase MGS1 Neighboring gene putative serine/threonine-protein phosphatase Neighboring gene Ies2p Neighboring gene Pex17p

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by GO

    Process Evidence Code Pubs
    chromatin silencing at silent mating-type cassette IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    chromatin silencing at telomere IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    establishment of chromatin silencing at telomere IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    establishment of protein localization to chromatin IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    establishment of protein localization to telomere IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    negative regulation of chromatin silencing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protection from non-homologous end joining at telomere IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    telomere maintenance via telomere lengthening IDA
    Inferred from Direct Assay
    more info
    PubMed 
    telomere maintenance via telomere lengthening IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear chromosome, telomeric region IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    telosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Names
    DNA-binding transcription factor RAP1
    NP_014183.1
    • Essential DNA-binding transcription regulator that binds many loci; involved in transcription activation and repression, chromatin silencing, and telomere length maintenance; relocalizes to the cytosol in response to hypoxia; conserved protein with an N-terminal BRCT domain, a central region with homology to the Myb DNA binding domain, and a C-terminal Rap1-specific protein-interaction domain (RCT domain)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      241689..244172
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183054.1NP_014183.1  DNA-binding transcription factor RAP1 [Saccharomyces cerevisiae S288c]

      See identical proteins and their annotated locations for NP_014183.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P11938
      Conserved Domains (5) summary
      smart00717
      Location:360413
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11653
      Location:727824
      rap1_RCT; C-terminal domain of RAP1 recruits proteins to telomeres
      cd11655
      Location:360413
      rap1_myb-like; DNA-binding modules of yeast Rap1 and related proteins
      pfam09197
      Location:448579
      Rap1-DNA-bind; Rap1, DNA-binding
      pfam16589
      Location:127207
      BRCT_2; BRCT domain, a BRCA1 C-terminus domain
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