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    AXL AXL receptor tyrosine kinase [ Homo sapiens (human) ]

    Gene ID: 558, updated on 12-Mar-2017
    Official Symbol
    AXLprovided by HGNC
    Official Full Name
    AXL receptor tyrosine kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:905
    See related
    Ensembl:ENSG00000167601 MIM:109135; Vega:OTTHUMG00000182727
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARK; UFO; JTK11; Tyro7
    Summary
    The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
    Orthologs
    Location:
    19q13.2
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 19 NC_000019.10 (41219199..41261767)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (41725104..41767672)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein L36 pseudogene 16 Neighboring gene cytochrome P450 family 2 subfamily S member 1 Neighboring gene transfer RNA-Lys (TTT) 10-1 Neighboring gene heterogeneous nuclear ribonucleoprotein U like 1 Neighboring gene RNA, 7SL, cytoplasmic 34, pseudogene Neighboring gene uncharacterized LOC105372401 Neighboring gene coiled-coil domain containing 97

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr upregulates the gene expression of AXL in human monocyte-derived dendritic cells PubMed
    capsid gag AXL inhibits the release of HIV-1 in terms of reduced levels of CA in virus particles and induces the accumulation of cell-associated CA PubMed

    Go to the HIV-1, Human Interaction Database

    • EGFR tyrosine kinase inhibitor resistance, organism-specific biosystem (from KEGG)
      EGFR tyrosine kinase inhibitor resistance, organism-specific biosystemEGFR is a tyrosine kinase that participates in the regulation of cellular homeostasis. EGFR also serves as a stimulus for cancer growth. EGFR gene mutations and protein overexpression, both of which ...
    • EGFR tyrosine kinase inhibitor resistance, conserved biosystem (from KEGG)
      EGFR tyrosine kinase inhibitor resistance, conserved biosystemEGFR is a tyrosine kinase that participates in the regulation of cellular homeostasis. EGFR also serves as a stimulus for cancer growth. EGFR gene mutations and protein overexpression, both of which ...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by VEGF, organism-specific biosystem (from REACTOME)
      Signaling by VEGF, organism-specific biosystemIn normal development vascular endothelial growth factors (VEGFs) are crucial regulators of vascular development during embryogenesis (vasculogenesis) and blood-vessel formation in the adult (angioge...
    • VEGFA-VEGFR2 Pathway, organism-specific biosystem (from REACTOME)
      VEGFA-VEGFR2 Pathway, organism-specific biosystemAngiogenesis is the formation of new blood vessels from preexisting vasculature. One of the most important proangiogenic factors is vascular endothelial growth factor (VEGF). VEGF exerts its biologic...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    myosin heavy chain binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol 3-kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylserine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein tyrosine kinase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    virus receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    animal organ regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    apoptotic cell clearance IEA
    Inferred from Electronic Annotation
    more info
     
    blood vessel remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    cell maturation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to extracellular stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to hydrogen peroxide IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to interferon-alpha IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendritic cell differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    erythrocyte homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    forebrain cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    natural killer cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of dendritic cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of interferon-gamma production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of lymphocyte activation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of tumor necrosis factor production IEA
    Inferred from Electronic Annotation
    more info
     
    neuron migration IEA
    Inferred from Electronic Annotation
    more info
     
    neutrophil clearance IEA
    Inferred from Electronic Annotation
    more info
     
    ovulation cycle IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    phagocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    platelet activation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cytokine-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of natural killer cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of pinocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein kinase B signaling IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase B signaling IEA
    Inferred from Electronic Annotation
    more info
     
    secretion by cell IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    substrate adhesion-dependent cell spreading IEA
    Inferred from Electronic Annotation
    more info
     
    vagina development IEA
    Inferred from Electronic Annotation
    more info
     
    vascular endothelial growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    viral entry into host cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    host cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    tyrosine-protein kinase receptor UFO
    Names
    AXL oncogene
    AXL transforming sequence/gene
    NP_001265528.1
    NP_001690.2
    NP_068713.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278599.1NP_001265528.1  tyrosine-protein kinase receptor UFO isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks four alternate exons in the 5' coding region and initiates translation at a downstream AUG, compared to variant 1. It encodes isoform 3 which has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AI300772, AI309979, AK309139, CA437238, X66029
      Consensus CDS
      CCDS62677.1
      UniProtKB/TrEMBL
      M0R0W6
      Related
      ENSP00000471497, OTTHUMP00000270030, ENST00000593513, OTTHUMT00000463401
      Conserved Domains (4) summary
      smart00221
      Location:270535
      STYKc; Protein kinase; unclassified specificity
      cd00063
      Location:2060
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05075
      Location:267543
      PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
      pfam00041
      Location:67150
      fn3; Fibronectin type III domain
    2. NM_001699.5NP_001690.2  tyrosine-protein kinase receptor UFO isoform 2 precursor

      See identical proteins and their annotated locations for NP_001690.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter than isoform 1.
      Source sequence(s)
      AA021223, AI300772, AI309979, AK309139, AL556721, BC032229, CA437238, HY045208, M76125, X66029
      Consensus CDS
      CCDS12574.1
      UniProtKB/Swiss-Prot
      P30530
      Related
      ENSP00000351995, OTTHUMP00000269993, ENST00000359092, OTTHUMT00000463324
      Conserved Domains (7) summary
      cd00096
      Location:53126
      Ig; Immunoglobulin domain
      cd05749
      Location:141222
      Ig2_Tyro3_like; Second immunoglobulin (Ig)-like domain of Axl/Tyro3 receptor tyrosine kinases (RTKs)
      smart00221
      Location:529794
      STYKc; Protein kinase; unclassified specificity
      smart00410
      Location:145223
      IG_like; Immunoglobulin like
      cd00063
      Location:225328
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05075
      Location:526802
      PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
      pfam00041
      Location:335418
      fn3; Fibronectin type III domain
    3. NM_021913.4NP_068713.2  tyrosine-protein kinase receptor UFO isoform 1 precursor

      See identical proteins and their annotated locations for NP_068713.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AA021223, AI300772, AI309979, AK309139, AL556721, BC032229, CA437238, HY045208, X66029
      Consensus CDS
      CCDS12575.1
      UniProtKB/Swiss-Prot
      P30530
      Related
      ENSP00000301178, OTTHUMP00000269992, ENST00000301178, OTTHUMT00000463323
      Conserved Domains (7) summary
      cd00096
      Location:53126
      Ig; Immunoglobulin domain
      cd05749
      Location:141222
      Ig2_Tyro3_like; Second immunoglobulin (Ig)-like domain of Axl/Tyro3 receptor tyrosine kinases (RTKs)
      smart00221
      Location:538803
      STYKc; Protein kinase; unclassified specificity
      smart00410
      Location:145223
      IG_like; Immunoglobulin like
      cd00063
      Location:225328
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05075
      Location:535811
      PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
      pfam00041
      Location:335418
      fn3; Fibronectin type III domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p7 Primary Assembly

      Range
      41219199..41261767
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018930.2 Alternate CHM1_1.1

      Range
      41724837..41767370
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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