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    Esr2 estrogen receptor 2 (beta) [ Mus musculus (house mouse) ]

    Gene ID: 13983, updated on 24-Mar-2017
    Official Symbol
    Esr2provided by MGI
    Official Full Name
    estrogen receptor 2 (beta)provided by MGI
    Primary source
    MGI:MGI:109392
    See related
    Ensembl:ENSMUSG00000021055 Vega:OTTMUSG00000021138
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ER[b]; Estrb; ERbeta
    Orthologs
    Location:
    12 C3; 12 33.52 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (76120419..76177259, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (77221406..77278246, complement)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 40447 Neighboring gene spectrin repeat containing, nuclear envelope 2 Neighboring gene microRNA 5101 Neighboring gene non-histone chromosomal protein HMG-14 pseudogene Neighboring gene testis expressed gene 21 Neighboring gene methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase Neighboring gene predicted gene, 40444

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Breast cancer, organism-specific biosystem (from KEGG)
      Breast cancer, organism-specific biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
    • Breast cancer, conserved biosystem (from KEGG)
      Breast cancer, conserved biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
    • Endocrine resistance, organism-specific biosystem (from KEGG)
      Endocrine resistance, organism-specific biosystemEndocrine therapy is a key treatment strategy to control or eradicate hormone-responsive breast cancer. The most commonly used endocrine therapy agents are selective estrogen receptor modulators (SER...
    • Endocrine resistance, conserved biosystem (from KEGG)
      Endocrine resistance, conserved biosystemEndocrine therapy is a key treatment strategy to control or eradicate hormone-responsive breast cancer. The most commonly used endocrine therapy agents are selective estrogen receptor modulators (SER...
    • Estrogen signaling pathway, organism-specific biosystem (from KEGG)
      Estrogen signaling pathway, organism-specific biosystemEstrogens are steroid hormones that regulate a plethora of physiological processes in mammals, including reproduction, cardiovascular protection, bone integrity, cellular homeostasis, and behavior. E...
    • Estrogen signaling pathway, conserved biosystem (from KEGG)
      Estrogen signaling pathway, conserved biosystemEstrogens are steroid hormones that regulate a plethora of physiological processes in mammals, including reproduction, cardiovascular protection, bone integrity, cellular homeostasis, and behavior. E...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
      Generic Transcription Pathway, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Nuclear Receptor transcription pathway, organism-specific biosystem (from REACTOME)
      Nuclear Receptor transcription pathway, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Nuclear Receptors, organism-specific biosystem (from WikiPathways)
      Nuclear Receptors, organism-specific biosystemNuclear receptors are a class of proteins found within the interior of cells that are responsible for sensing the presence of steroid and thyroid hormones and certain other molecules. In response, th...
    • Ovarian Infertility Genes, organism-specific biosystem (from WikiPathways)
      Ovarian Infertility Genes, organism-specific biosystem
      Ovarian Infertility Genes
    • Prolactin signaling pathway, organism-specific biosystem (from KEGG)
      Prolactin signaling pathway, organism-specific biosystemProlactin (PRL) is a polypeptide hormone known to be involved in a wide range of biological functions including osmoregulation, lactation, reproduction, growth and development, endocrinology and meta...
    • Prolactin signaling pathway, conserved biosystem (from KEGG)
      Prolactin signaling pathway, conserved biosystemProlactin (PRL) is a polypeptide hormone known to be involved in a wide range of biological functions including osmoregulation, lactation, reproduction, growth and development, endocrinology and meta...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II core promoter proximal region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    core promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    drug binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    estradiol binding ISO
    Inferred from Sequence Orthology
    more info
     
    estrogen receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    estrogen response element binding ISO
    Inferred from Sequence Orthology
    more info
     
    hormone binding ISO
    Inferred from Sequence Orthology
    more info
     
    lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    peroxisome proliferator activated receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    steroid binding ISO
    Inferred from Sequence Orthology
    more info
     
    steroid hormone binding ISO
    Inferred from Sequence Orthology
    more info
     
    steroid hormone receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor activity, sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    Sertoli cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    behavioral fear response ISO
    Inferred from Sequence Orthology
    more info
     
    brain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to estradiol stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    epithelial cell maturation involved in prostate gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    estrous cycle ISO
    Inferred from Sequence Orthology
    more info
     
    hormone-mediated apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular estrogen receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular estrogen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular steroid hormone receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    learning or memory ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of androgen receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of behavior ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of feeding behavior ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ovarian follicle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of blood vessel diameter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of sequence-specific DNA binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    prostate gland epithelium morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    response to testosterone ISO
    Inferred from Sequence Orthology
    more info
     
    steroid hormone mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    uterus development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    vagina development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    cilium ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    protein-DNA complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    estrogen receptor beta
    Names
    ER-beta
    nuclear receptor subfamily 3 group A member 2
    oestrogen receptor beta

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010157.3NP_034287.3  estrogen receptor beta isoform 2

      See identical proteins and their annotated locations for NP_034287.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AK054413
      Consensus CDS
      CCDS25987.1
      UniProtKB/Swiss-Prot
      O08537
      UniProtKB/TrEMBL
      A0A0R4J1F1
      Related
      ENSMUSP00000075932, ENSMUST00000076634
      Conserved Domains (3) summary
      cd06949
      Location:282517
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:163244
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam12497
      Location:35141
      ERbeta_N; Estrogen receptor beta
    2. NM_207707.1NP_997590.1  estrogen receptor beta isoform 1

      See identical proteins and their annotated locations for NP_997590.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK054413
      Consensus CDS
      CCDS25988.1
      UniProtKB/Swiss-Prot
      O08537
      UniProtKB/TrEMBL
      A0A0R4J191
      Related
      ENSMUSP00000098849, OTTMUSP00000023324, ENSMUST00000101291, OTTMUST00000050081
      Conserved Domains (3) summary
      cd06949
      Location:282535
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:163244
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam12497
      Location:35141
      ERbeta_N; Estrogen receptor beta

    RNA

    1. NR_104386.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two consecutive internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK054301, AK054413
      Related
      ENSMUST00000133564, OTTMUST00000050082

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      76120419..76177259 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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