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    Zfp57 zinc finger protein 57 [ Mus musculus (house mouse) ]

    Gene ID: 22715, updated on 25-Jun-2017
    Official Symbol
    Zfp57provided by MGI
    Official Full Name
    zinc finger protein 57provided by MGI
    Primary source
    MGI:MGI:99204
    See related
    Ensembl:ENSMUSG00000036036 Vega:OTTMUSG00000037387
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    G19; Zfp-57
    Orthologs
    Location:
    17 B1; 17
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (37001163..37010729)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (37138108..37147674)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2410137M14 gene Neighboring gene histocompatibility 2, M region locus 4, pseudogene Neighboring gene histocompatibility 2, M region locus 5 Neighboring gene myelin oligodendrocyte glycoprotein Neighboring gene predicted gene, 33802 Neighboring gene gamma-aminobutyric acid (GABA) B receptor, 1

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • PluriNetWork, organism-specific biosystem (from WikiPathways)
      PluriNetWork, organism-specific biosystemThe aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we inten...

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013745.2NP_001013767.1  zinc finger protein 57 isoform 1

      See identical proteins and their annotated locations for NP_001013767.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes the longer isoform (1). Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      BC052028, CF731693, CR956641
      Consensus CDS
      CCDS28733.1
      UniProtKB/Swiss-Prot
      Q8C6P8
      Related
      ENSMUSP00000065811.7, OTTMUSP00000053906, ENSMUST00000069250.13, OTTMUST00000096472
      Conserved Domains (5) summary
      smart00349
      Location:1572
      KRAB; krueppel associated box
      COG5048
      Location:139309
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:92134
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:169190
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:1554
      KRAB; KRAB box
    2. NM_001168501.1NP_001161973.1  zinc finger protein 57 isoform 1

      See identical proteins and their annotated locations for NP_001161973.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs at the 5' end compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AV579696, BC052028, CR956641
      Consensus CDS
      CCDS28733.1
      UniProtKB/Swiss-Prot
      Q8C6P8
      Related
      ENSMUSP00000134418.1, OTTMUSP00000053908, ENSMUST00000174524.7, OTTMUST00000096479
      Conserved Domains (5) summary
      smart00349
      Location:1572
      KRAB; krueppel associated box
      COG5048
      Location:139309
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:92134
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:169190
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:1554
      KRAB; KRAB box
    3. NM_001168502.1NP_001161974.1  zinc finger protein 57 isoform 2

      See identical proteins and their annotated locations for NP_001161974.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs at the 5' end and uses an alternate, in-frame acceptor splice site at one of the coding exons compared to variant 1. This results in a shorter isoform (2) missing three internal aa compared to isoform 1.
      Source sequence(s)
      AK139625, BC052028, CR956641
      Consensus CDS
      CCDS50106.1
      UniProtKB/Swiss-Prot
      Q8C6P8
      Related
      ENSMUSP00000087414.6, OTTMUSP00000053905, ENSMUST00000089968.12, OTTMUST00000096470
      Conserved Domains (5) summary
      smart00349
      Location:1269
      KRAB; krueppel associated box
      COG5048
      Location:136306
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:89131
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:166187
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:1251
      KRAB; KRAB box

    RNA

    1. NR_033137.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs at the 5' end compared to variant 1, and contains an upstream ORF with a strong Kozak signal, which according to leaky scanning model could interfere with the translation of the downstream primary ORF. Translation from the upstream ORF will render this transcript a candidate for nonsense-mediated mRNA decay (NMD). However, this variant transcript is sufficiently abundant to represent as a non-coding RefSeq record.
      Source sequence(s)
      AK143118, BC052028, CR956641

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      37001163..37010729
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317458.1XP_017172947.1  zinc finger protein 57 isoform X2

      UniProtKB/Swiss-Prot
      Q8C6P8
      Conserved Domains (5) summary
      smart00349
      Location:1269
      KRAB; krueppel associated box
      COG5048
      Location:136306
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:89131
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:166187
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:1251
      KRAB; KRAB box
    2. XM_017317459.1XP_017172948.1  zinc finger protein 57 isoform X2

      UniProtKB/Swiss-Prot
      Q8C6P8
      Conserved Domains (5) summary
      smart00349
      Location:1269
      KRAB; krueppel associated box
      COG5048
      Location:136306
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:89131
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:166187
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:1251
      KRAB; KRAB box
    3. XM_006524224.1XP_006524287.1  zinc finger protein 57 isoform X1

      See identical proteins and their annotated locations for XP_006524287.1

      UniProtKB/Swiss-Prot
      Q8C6P8
      Related
      ENSMUSP00000133821.1, OTTMUSP00000053909, ENSMUST00000174672.1, OTTMUST00000096480
      Conserved Domains (5) summary
      smart00349
      Location:1572
      KRAB; krueppel associated box
      COG5048
      Location:139309
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:92134
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:169190
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:1554
      KRAB; KRAB box

    Reference GRCm38.p4 129S1/SvImJ

    Genomic

    1. NT_187009.1 Reference GRCm38.p4 129S1/SvImJ

      Range
      955936..965531
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 NOD/MrkTac

    Genomic

    1. NT_187027.1 Reference GRCm38.p4 NOD/MrkTac

      Range
      3286659..3296199
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 NOD/ShiLtJ

    Genomic

    1. NT_187004.1 Reference GRCm38.p4 NOD/ShiLtJ

      Range
      3362301..3371841
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_009559.2: Suppressed sequence

      Description
      NM_009559.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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