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    par-6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32752, updated on 19-May-2018
    Official Symbol
    par-6provided by FlyBase
    Primary source
    FLYBASE:FBgn0026192
    Locus tag
    Dmel_CG5884
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster (old-lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5884; Dm-Par-6; Dm-Par6; Dmel\CG5884; dmPar-6; DmPar-6; DmPAR-6; Dmpar6; DmPar6; dPar-6; dPAR-6; DPar-6; DPar6; par; Par; Par-6; PAR-6; par6; Par6; PAR6
    See par-6 in Genome Data Viewer
    Location:
    16C1-16C1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.13 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17703352..17707096)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17597385..17601129)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene chascon Neighboring gene CG8188 Neighboring gene CG8173 Neighboring gene uncharacterized protein

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    apical protein localization NAS
    Non-traceable Author Statement
    more info
    PubMed 
    asymmetric neuroblast division IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    border follicle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    branching involved in open tracheal system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment of neuroblast polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment or maintenance of epithelial cell apical/basal polarity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    establishment or maintenance of neuroblast polarity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    establishment or maintenance of polarity of embryonic epithelium NAS
    Non-traceable Author Statement
    more info
    PubMed 
    morphogenesis of a polarized epithelium TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of filopodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of lamellipodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    terminal branching, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    zonula adherens assembly NAS
    Non-traceable Author Statement
    more info
    PubMed 
    zonula adherens assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    apical cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apical cortex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apical plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    cell cortex TAS
    Traceable Author Statement
    more info
    PubMed 
    muscle cell postsynaptic specialization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    subapical complex TAS
    Traceable Author Statement
    more info
    PubMed 
    terminal bouton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    par-6
    Names
    CG5884-PA
    CG5884-PB
    Par-6
    par-6-PA
    par-6-PB

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      17703352..17707096
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_133010.5NP_573238.1  par-6, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573238.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O97111
      Related
      FBpp0074229.1, FBtr0074455
      Conserved Domains (2) summary
      cd06403
      Location:20101
      PB1_Par6; The PB1 domain is an essential part of Par6 protein which in complex with Par3 and aPKC proteins is crucial for establishment of apical-basal polarity of animal cells. The PB1 domain is a modular domain mediating specific protein-protein interactions ...
      cd00992
      Location:159250
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    2. NM_167575.2NP_728094.1  par-6, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728094.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O97111
      Related
      FBpp0074230.1, FBtr0074456
      Conserved Domains (2) summary
      cd06403
      Location:20101
      PB1_Par6; The PB1 domain is an essential part of Par6 protein which in complex with Par3 and aPKC proteins is crucial for establishment of apical-basal polarity of animal cells. The PB1 domain is a modular domain mediating specific protein-protein interactions ...
      cd00992
      Location:159250
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
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