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    Hc hemolytic complement [ Mus musculus (house mouse) ]

    Gene ID: 15139, updated on 9-May-2017
    Official Symbol
    Hcprovided by MGI
    Official Full Name
    hemolytic complementprovided by MGI
    Primary source
    MGI:MGI:96031
    See related
    Ensembl:ENSMUSG00000026874 Vega:OTTMUSG00000012274
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C5; He; C5a
    Summary
    This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC). Mice with a homozygous mutation in this gene exhibit impaired bone fracture healing and an enhanced inflammatory response in an allergic lung disease model. [provided by RefSeq, Nov 2015]
    Orthologs
    Location:
    2 B; 2 23.22 cM
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (34983329..35067034, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (34838851..34916961, complement)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46733 Neighboring gene mitochondrial import receptor subunit TOM7 homolog Neighboring gene predicted gene, 39794 Neighboring gene expressed sequence AI182371 Neighboring gene predicted gene, 46734

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    complement activation, alternative pathway IEA
    Inferred from Electronic Annotation
    more info
     
    complement activation, classical pathway IEA
    Inferred from Electronic Annotation
    more info
     
    cytolysis IEA
    Inferred from Electronic Annotation
    more info
     
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    in utero embryonic development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of macrophage chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of chemokine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of vascular endothelial growth factor production ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    membrane attack complex ISO
    Inferred from Sequence Orthology
    more info
     

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010406.2NP_034536.2  complement C5 preproprotein

      Status: REVIEWED

      Source sequence(s)
      AL845534, M35525
      Consensus CDS
      CCDS15957.1
      UniProtKB/Swiss-Prot
      P06684
      Related
      ENSMUSP00000028233.3, OTTMUSP00000013195, ENSMUST00000028233.6, OTTMUST00000029212
      Conserved Domains (8) summary
      cd00017
      Location:691759
      ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
      cd02896
      Location:10041309
      complement_C3_C4_C5; Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the ...
      pfam00207
      Location:781868
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:131223
      A2M_N; MG2 domain
      pfam07677
      Location:14281518
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:10601310
      A2M_comp; A-macroglobulin complement component
      pfam07703
      Location:475615
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      cl02512
      Location:15361684
      NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      34983329..35067034 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315669.1XP_017171158.1  complement C5 isoform X1

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