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    SSB Sjogren syndrome antigen B [ Homo sapiens (human) ]

    Gene ID: 6741, updated on 1-Dec-2016
    Official Symbol
    SSBprovided by HGNC
    Official Full Name
    Sjogren syndrome antigen Bprovided by HGNC
    Primary source
    HGNC:HGNC:11316
    See related
    Ensembl:ENSG00000138385 MIM:109090; Vega:OTTHUMG00000132212
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    La; LARP3; La/SSB
    Summary
    The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein. [provided by RefSeq, Jun 2014]
    Orthologs
    Location:
    2q31.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 2 NC_000002.12 (169798812..169812064)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (170655322..170668574)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene patched domain containing 3 pseudogene 2 Neighboring gene cytochrome b5 type A pseudogene 2 Neighboring gene methyltransferase like 5 Neighboring gene ubiquitin protein ligase E3 component n-recognin 3 (putative) Neighboring gene NSA2 ribosome biogenesis homolog (S. cerevisiae) pseudogene Neighboring gene RNA, U6 small nuclear 1006, pseudogene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Replication interactions

    Interaction Pubs
    Knockdown of Sjogren syndrome antigen B (SSB) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev is identified to have a physical interaction with Sjogren syndrome antigen B ( SSB) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    rev HIV-1 Rev interacting protein, Sjogren syndrome antigen B (SSB), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with SSB is increased by RRE PubMed
    Tat tat The La autoantigen binds to HIV-1 TAR RNA and alleviates translational repression by the HIV-1 leader RNA, suggesting a possible involvement of the La autoantigen in HIV-1 gene expression and Tat transactivation PubMed
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of Sjogren syndrome antigen B (SSB, autoantigen La) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human Sjogren syndrome antigen B (SSB; autoantigen La) at amino acid residues 24-25 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    mRNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    poly(A) RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    tRNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    IRES-dependent viral translational initiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone mRNA metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    protein localization to cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    tRNA modification TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    intracellular ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    lupus La protein
    Names
    La ribonucleoprotein domain family, member 3
    SS-B
    SS-B/La protein
    autoantigen La
    la autoantigen
    lupus La antigen
    sjoegren syndrome type B antigen

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030640.1 RefSeqGene

      Range
      5001..18253
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001294145.1NP_001281074.1  lupus La protein

      See identical proteins and their annotated locations for NP_001281074.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate 5' UTR exon and encodes the same protein, compared to variant 1.
      Source sequence(s)
      AC009967, BC001289, X69804
      Consensus CDS
      CCDS2237.1
      UniProtKB/Swiss-Prot
      P05455
      Related
      ENSP00000386636, OTTHUMP00000204778, ENST00000409333, OTTHUMT00000333316
      Conserved Domains (3) summary
      cd08028
      Location:1091
      LARP_3; La RNA-binding domain of La-related protein 3
      cd12291
      Location:112183
      RRM1_La; RNA recognition motif 1 in La autoantigen (La or LARP3) and similar proteins
      pfam08777
      Location:231334
      RRM_3; RNA binding motif
    2. NM_003142.4NP_003133.1  lupus La protein

      See identical proteins and their annotated locations for NP_003133.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) and variant 2 encode the same protein.
      Source sequence(s)
      BC001289, CD676196
      Consensus CDS
      CCDS2237.1
      UniProtKB/Swiss-Prot
      P05455
      Related
      ENSP00000260956, OTTHUMP00000163067, ENST00000260956, OTTHUMT00000255270
      Conserved Domains (3) summary
      cd08028
      Location:1091
      LARP_3; La RNA-binding domain of La-related protein 3
      cd12291
      Location:112183
      RRM1_La; RNA recognition motif 1 in La autoantigen (La or LARP3) and similar proteins
      pfam08777
      Location:231334
      RRM_3; RNA binding motif

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p7 Primary Assembly

      Range
      169798812..169812064
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018913.2 Alternate CHM1_1.1

      Range
      170659176..170674430
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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