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    F2rl1 coagulation factor II (thrombin) receptor-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 14063, updated on 25-Jun-2017
    Official Symbol
    F2rl1provided by MGI
    Official Full Name
    coagulation factor II (thrombin) receptor-like 1provided by MGI
    Primary source
    MGI:MGI:101910
    See related
    Ensembl:ENSMUSG00000021678
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Par2; PAR-2; Gpcr11
    Orthologs
    Location:
    13 D1; 13 49.53 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (95511718..95525240, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (96281673..96295195, complement)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene corticotropin releasing hormone binding protein Neighboring gene S100 calcium binding protein, zeta Neighboring gene predicted gene, 32640 Neighboring gene coagulation factor II (thrombin) receptor

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    G-protein alpha-subunit binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    G-protein beta-subunit binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    G-protein coupled receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    G-protein coupled receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    heterotrimeric G-protein binding TAS
    Traceable Author Statement
    more info
    PubMed 
    signal transducer activity IEA
    Inferred from Electronic Annotation
    more info
     
    thrombin-activated receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    T cell activation involved in immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    blood coagulation IEA
    Inferred from Electronic Annotation
    more info
     
    chemokine (C-C motif) ligand 2 secretion ISO
    Inferred from Sequence Orthology
    more info
     
    chemokine secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chemokine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    defense response to virus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    defense response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    establishment of endothelial barrier ISO
    Inferred from Sequence Orthology
    more info
     
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    interferon-gamma secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    interleukin-1 beta secretion ISO
    Inferred from Sequence Orthology
    more info
     
    interleukin-10 secretion ISO
    Inferred from Sequence Orthology
    more info
     
    leukocyte migration ISO
    Inferred from Sequence Orthology
    more info
     
    leukocyte proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mature conventional dendritic cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mature conventional dendritic cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of chemokine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of toll-like receptor 3 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of tumor necrosis factor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    neutrophil activation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of Rho protein signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of actin filament depolymerization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of blood vessel diameter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of blood vessel diameter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of blood vessel diameter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cytokine secretion involved in immune response ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of eosinophil degranulation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glomerular filtration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-6 secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-8 secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of leukocyte chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neutrophil mediated killing of gram-negative bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of phagocytosis, engulfment ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of phosphatidylinositol 3-kinase signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of positive chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of pseudopodium assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of renin secretion into blood stream IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of superoxide anion generation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of toll-like receptor 2 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of toll-like receptor 3 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of toll-like receptor 4 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of blood coagulation ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    thrombin-activated receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    pseudopodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    proteinase-activated receptor 2
    Names
    G-protein coupled receptor 11
    Protease-activated receptor-2
    coagulation factor II receptor-like 1
    thrombin receptor-like 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007974.4NP_032000.3  proteinase-activated receptor 2 precursor

      See identical proteins and their annotated locations for NP_032000.3

      Status: VALIDATED

      Source sequence(s)
      AK160916, BY029876, DV551864
      Consensus CDS
      CCDS26700.1
      UniProtKB/Swiss-Prot
      P55086
      UniProtKB/TrEMBL
      Q3TU81
      Related
      ENSMUSP00000022185.8, ENSMUST00000022185.9
      Conserved Domains (2) summary
      pfam00001
      Location:95346
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:156363
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

      Range
      95511718..95525240 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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