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    APOA1 apolipoprotein A1 [ Homo sapiens (human) ]

    Gene ID: 335, updated on 22-Apr-2017
    Official Symbol
    APOA1provided by HGNC
    Official Full Name
    apolipoprotein A1provided by HGNC
    Primary source
    HGNC:HGNC:600
    See related
    Ensembl:ENSG00000118137 MIM:107680; Vega:OTTHUMG00000046112
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    apo(a)
    Summary
    This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The encoded preproprotein is proteolytically processed to generate the mature protein, which promotes cholesterol efflux from tissues to the liver for excretion, and is a cofactor for lecithin cholesterolacyltransferase (LCAT), an enzyme responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein. [provided by RefSeq, Dec 2015]
    Orthologs
    Location:
    11q23.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 11 NC_000011.10 (116835751..116837950, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (116706467..116708338, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene apolipoprotein A4 Neighboring gene APOA1 antisense RNA Neighboring gene apolipoprotein C3 Neighboring gene SIK family kinase 3 Neighboring gene RNA, Ro-associated Y4 pseudogene 6 Neighboring gene ribosomal protein S27 pseudogene 19

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Familial hypoalphalipoproteinemia
    MedGen: C1704429 OMIM: 604091 GeneReviews: Not available
    Compare labs
    Familial visceral amyloidosis, Ostertag type
    MedGen: C0268389 OMIM: 105200 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    A genome wide association study identifies common variants associated with lipid levels in the Chinese population.
    NHGRI GWA Catalog
    A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotection.
    NHGRI GWA Catalog
    Biological, clinical and population relevance of 95 loci for blood lipids.
    NHGRI GWA Catalog
    Common variants at 30 loci contribute to polygenic dyslipidemia.
    NHGRI GWA Catalog
    Discovery and refinement of loci associated with lipid levels.
    NHGRI GWA Catalog
    Genetic variants influencing circulating lipid levels and risk of coronary artery disease.
    NHGRI GWA Catalog
    Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia.
    NHGRI GWA Catalog
    Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
    NHGRI GWA Catalog
    Genome-wide association study of hematological and biochemical traits in a Japanese population.
    NHGRI GWA Catalog
    Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides.
    NHGRI GWA Catalog
    Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
    NHGRI GWA Catalog
    Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
    NHGRI GWA Catalog
    Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.
    NHGRI GWA Catalog
    Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.
    NHGRI GWA Catalog
    Newly identified loci that influence lipid concentrations and risk of coronary artery disease.
    NHGRI GWA Catalog
    Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.
    NHGRI GWA Catalog
    Plasma lipids, genetic variants near APOA1, and the risk of infantile hypertrophic pyloric stenosis.
    NHGRI GWA Catalog
    Salt-inducible kinase 3, SIK3, is a new gene associated with hearing.
    NHGRI GWA Catalog
    Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
    NHGRI GWA Catalog
    Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Apolipoprotein A-1 competes with CD4 receptor binding to HIV-1 gp120 in human lymphocytes PubMed
    Nef nef HIV-1 Nef impairs cholesterol efflux from macrophages and inhibits internalization of apolipoprotein A1 from the plasma membrane PubMed
    nef Cav-1 interacts with HIV-1 Nef and restores Nef mediated impairment of apoA-I mediated cholesterol efflux in astrocyte derived glioblastoma cells and macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    • ABC transporters in lipid homeostasis, organism-specific biosystem (from REACTOME)
      ABC transporters in lipid homeostasis, organism-specific biosystemA defined subset of the ABC transporter superfamily, the ABCA transporters, are highly expressed in monocytes and macrophages and are regulated by cholesterol flux which may indicate their role in in...
    • ABC-family proteins mediated transport, organism-specific biosystem (from REACTOME)
      ABC-family proteins mediated transport, organism-specific biosystemThe ATP-binding cassette (ABC) superfamily of active transporters involves a large number of functionally diverse transmembrane proteins. They transport a variety of compounds through membranes agai...
    • African trypanosomiasis, organism-specific biosystem (from KEGG)
      African trypanosomiasis, organism-specific biosystemTrypanosoma brucei, the parasite responsible for African trypanosomiasis (sleeping sickness), are spread by the tsetse fly in sub-Saharan Africa. The parasites are able to pass through the blood-brai...
    • African trypanosomiasis, conserved biosystem (from KEGG)
      African trypanosomiasis, conserved biosystemTrypanosoma brucei, the parasite responsible for African trypanosomiasis (sleeping sickness), are spread by the tsetse fly in sub-Saharan Africa. The parasites are able to pass through the blood-brai...
    • Amyloid fiber formation, organism-specific biosystem (from REACTOME)
      Amyloid fiber formation, organism-specific biosystemAmyloid is a term used to describe deposits of fibrillar proteins, typically extracellular. The abnormal accumulation of amyloid, amyloidosis, is a term associated with tissue damage caused by amyloi...
    • Binding and Uptake of Ligands by Scavenger Receptors, organism-specific biosystem (from REACTOME)
      Binding and Uptake of Ligands by Scavenger Receptors, organism-specific biosystemScavenger receptors bind free extracellular ligands as the initial step in clearance of the ligands from the body (reviewed in Ascenzi et al. 2005, Areschoug and Gordon 2009, Nielsen et al. 2010). So...
    • Chylomicron-mediated lipid transport, organism-specific biosystem (from REACTOME)
      Chylomicron-mediated lipid transport, organism-specific biosystemChylomicrons transport triacylglycerol, phospholipid, and cholesterol derived from dietary lipid from the small intestine to other tissues of the body. Each chylomicron assembles around a single mole...
    • Composition of Lipid Particles, organism-specific biosystem (from WikiPathways)
      Composition of Lipid Particles, organism-specific biosystemThis particle describes the chemical composition of various lipid particles. See also WP430 and other pathways. Additional sources - A. Goldberg, Overview of Lipid Metabolism, 2015. http://www.msdma...
    • FOXA2 and FOXA3 transcription factor networks, organism-specific biosystem (from Pathway Interaction Database)
      FOXA2 and FOXA3 transcription factor networks, organism-specific biosystem
      FOXA2 and FOXA3 transcription factor networks
    • Fat digestion and absorption, organism-specific biosystem (from KEGG)
      Fat digestion and absorption, organism-specific biosystemFat is an important energy source from food. More than 95% of dietary fat is long-chain triacylglycerols (TAG), the remaining being phospholipids (4.5%) and sterols. In the small intestine lumen, die...
    • Fat digestion and absorption, conserved biosystem (from KEGG)
      Fat digestion and absorption, conserved biosystemFat is an important energy source from food. More than 95% of dietary fat is long-chain triacylglycerols (TAG), the remaining being phospholipids (4.5%) and sterols. In the small intestine lumen, die...
    • Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
      Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemThe reactions involved in the metabolism of fatty acids and of the triacylglycerols and ketone bodies derived from them form a closely interrelated, coordinately regulated module that plays a central...
    • Folate Metabolism, organism-specific biosystem (from WikiPathways)
      Folate Metabolism, organism-specific biosystem
      Folate Metabolism
    • HDL-mediated lipid transport, organism-specific biosystem (from REACTOME)
      HDL-mediated lipid transport, organism-specific biosystemHDL particles play a central role in the reverse transport of cholesterol, the process by which cholesterol in tissues other than the liver is returned to the liver for conversion to bile salts and e...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Lipid digestion, mobilization, and transport, organism-specific biosystem (from REACTOME)
      Lipid digestion, mobilization, and transport, organism-specific biosystemProcesses annotated here include the digestion of dietary lipids, sterol uptake, the formation and turnover of lipoproteins (chylomicrons, VLDL, LDL, and HDL), and the mobilization of fatty acids thr...
    • Lipoprotein metabolism, organism-specific biosystem (from REACTOME)
      Lipoprotein metabolism, organism-specific biosystemBecause of their hydrophobicity, lipids are found in the extracellular spaces of the human body primarily in the form of lipoprotein complexes. Chylomicrons form in the small intestine and transport ...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of fat-soluble vitamins, organism-specific biosystem (from REACTOME)
      Metabolism of fat-soluble vitamins, organism-specific biosystemVitamins A, D, E, and K are classified as fat-soluble. Metabolic pathways by which dietary precursors of vitamins A (Harrison 2005) and K(Shearer et al. 2012) are converted to active forms, and by wh...
    • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
      Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Metabolism of vitamins and cofactors, organism-specific biosystem (from REACTOME)
      Metabolism of vitamins and cofactors, organism-specific biosystemVitamins are a diverse group of organic compounds, classified according to their solubility, either fat-soluble or water-soluble, that are either not synthesized or synthesized only in limited amount...
    • PPAR Alpha Pathway, organism-specific biosystem (from WikiPathways)
      PPAR Alpha Pathway, organism-specific biosystemPPAR alpha (also known as NR1C1) is a nuclear receptor that is involved with transcriptional regulation of genes involved in beta-oxidation, metabolism, fatty acid transport, etc.
    • PPAR signaling pathway, organism-specific biosystem (from KEGG)
      PPAR signaling pathway, organism-specific biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
    • PPAR signaling pathway, conserved biosystem (from KEGG)
      PPAR signaling pathway, conserved biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
    • PPARA activates gene expression, organism-specific biosystem (from REACTOME)
      PPARA activates gene expression, organism-specific biosystemThe set of genes regulated by PPAR-alpha is not fully known in humans, however many examples have been found in mice. Genes directly activated by PPAR-alpha contain peroxisome proliferator receptor e...
    • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
      Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...
    • Platelet degranulation, organism-specific biosystem (from REACTOME)
      Platelet degranulation, organism-specific biosystemPlatelets function as exocytotic cells, secreting a plethora of effector molecules at sites of vascular injury. Platelets contain a number of distinguishable storage granules including alpha granules...
    • Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem (from REACTOME)
      Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystemPeroxisome proliferator-activated receptor alpha (PPAR-alpha) is the major regulator of fatty acid oxidation in the liver. PPARalpha is also the target of fibrate drugs used to treat abnormal plasma ...
    • Response to elevated platelet cytosolic Ca2+, organism-specific biosystem (from REACTOME)
      Response to elevated platelet cytosolic Ca2+, organism-specific biosystemActivation of phospholipase C enzymes results in the generation of second messengers of the phosphatidylinositol pathway. The events resulting from this pathway are a rise in intracellular calcium an...
    • Retinoid metabolism and transport, organism-specific biosystem (from REACTOME)
      Retinoid metabolism and transport, organism-specific biosystemVitamin A (all-trans-retinol) must be taken up, either as carotenes from plants, or as retinyl esters from animal food. The most prominent carotenes are alpha-carotene, lycopene, lutein, beta-cryptox...
    • Scavenging by Class A Receptors, organism-specific biosystem (from REACTOME)
      Scavenging by Class A Receptors, organism-specific biosystemClass A scavenger receptors contain an intracellular domain, a transmembrane region, a coiled-coil domain, a collagenous domain, and the SR cysteine-rich domain (reviewed in Areschoug and Gordon 2009...
    • Scavenging by Class B Receptors, organism-specific biosystem (from REACTOME)
      Scavenging by Class B Receptors, organism-specific biosystemClass B receptors have two transmembrane domains separated by an extracellular loop (reviewed in Adachi and Tsujimoto 2006, Areschoug and Gordon 2009).
    • Scavenging of heme from plasma, organism-specific biosystem (from REACTOME)
      Scavenging of heme from plasma, organism-specific biosystemFree heme is damaging to tissues as it intercalates into biologic membranes, perturbing lipid bilayers and promoting the conversion of low-density lipoprotein to cytotoxic oxidized products. Moreover...
    • Selenium Micronutrient Network, organism-specific biosystem (from WikiPathways)
      Selenium Micronutrient Network, organism-specific biosystem
      Selenium Micronutrient Network
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Statin Pathway, organism-specific biosystem (from WikiPathways)
      Statin Pathway, organism-specific biosystemStatins inhibit endogenous cholesterol production by competitive inhibition of HMG-CoA reductase (HMGCR), the enzyme that catalyzes conversion of HMG-CoA to mevalonate, an early rate-limiting step in...
    • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
      Transmembrane transport of small molecules, organism-specific biosystem
      Transmembrane transport of small molecules
    • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
      Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
    • Visual phototransduction, organism-specific biosystem (from REACTOME)
      Visual phototransduction, organism-specific biosystemVisual phototransduction is the process by which photon absorption by visual pigment molecules in photoreceptor cells is converted to an electrical cellular response. The events in this process are p...
    • Vitamin B12 Metabolism, organism-specific biosystem (from WikiPathways)
      Vitamin B12 Metabolism, organism-specific biosystem
      Vitamin B12 Metabolism
    • Vitamin digestion and absorption, organism-specific biosystem (from KEGG)
      Vitamin digestion and absorption, organism-specific biosystemVitamins are a diverse and chemically unrelated group of organic substances that share a common feature of being essential for normal health and well-being. They catalyze numerous biochemical reactio...
    • Vitamin digestion and absorption, conserved biosystem (from KEGG)
      Vitamin digestion and absorption, conserved biosystemVitamins are a diverse and chemically unrelated group of organic substances that share a common feature of being essential for normal health and well-being. They catalyze numerous biochemical reactio...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC117399

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    apolipoprotein A-I receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    apolipoprotein receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    beta-amyloid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chemorepellent activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cholesterol binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to cholesterol transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cholesterol transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    heat shock protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    high-density lipoprotein particle binding IEA
    Inferred from Electronic Annotation
    more info
     
    high-density lipoprotein particle receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    lipase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylcholine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    phosphatidylcholine-sterol O-acyltransferase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phospholipid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phospholipid transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    NOT ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    G-protein coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adrenal gland development IEA
    Inferred from Electronic Annotation
    more info
     
    animal organ regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    blood vessel endothelial cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    cellular protein metabolic process TAS
    Traceable Author Statement
    more info
     
    cholesterol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cholesterol efflux IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cholesterol efflux IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cholesterol homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cholesterol homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cholesterol import IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cholesterol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cholesterol transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endothelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    glucocorticoid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    high-density lipoprotein particle assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    high-density lipoprotein particle clearance IC
    Inferred by Curator
    more info
    PubMed 
    high-density lipoprotein particle remodeling IC
    Inferred by Curator
    more info
    PubMed 
    high-density lipoprotein particle remodeling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integrin-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipid storage IEA
    Inferred from Electronic Annotation
    more info
     
    lipoprotein biosynthetic process TAS
    Traceable Author Statement
    more info
     
    lipoprotein metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    lipoprotein metabolic process TAS
    Traceable Author Statement
    more info
     
    negative chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cell adhesion molecule production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cytokine secretion involved in immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of heterotypic cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of inflammatory response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of interleukin-1 beta secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of lipase activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of response to cytokine stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of tumor necrosis factor-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of very-low-density lipoprotein particle remodeling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection regeneration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    peptidyl-methionine modification IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peripheral nervous system axon regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylcholine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phospholipid efflux IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phospholipid homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    platelet degranulation TAS
    Traceable Author Statement
    more info
     
    positive regulation of Rho protein signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cholesterol esterification IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of hydrolase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of lipoprotein lipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of stress fiber assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of substrate adhesion-dependent cell spreading IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of triglyceride catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein oxidation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein stabilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    receptor-mediated endocytosis TAS
    Traceable Author Statement
    more info
     
    regulation of Cdc42 protein signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of intestinal cholesterol absorption IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    response to drug IEA
    Inferred from Electronic Annotation
    more info
     
    response to estrogen IEA
    Inferred from Electronic Annotation
    more info
     
    response to nutrient IEA
    Inferred from Electronic Annotation
    more info
     
    retinoid metabolic process TAS
    Traceable Author Statement
    more info
     
    reverse cholesterol transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transmembrane transport TAS
    Traceable Author Statement
    more info
     
    triglyceride catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    triglyceride homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    vitamin transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    blood microparticle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    chylomicron IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    discoidal high-density lipoprotein particle IEA
    Inferred from Electronic Annotation
    more info
     
    early endosome TAS
    Traceable Author Statement
    more info
     
    endocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endocytic vesicle lumen TAS
    Traceable Author Statement
    more info
     
    endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    extracellular vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    high-density lipoprotein particle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    secretory granule lumen TAS
    Traceable Author Statement
    more info
     
    spherical high-density lipoprotein particle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    very-low-density lipoprotein particle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    apolipoprotein A-I
    Names
    apo-AI

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012021.1 RefSeqGene

      Range
      5001..6870
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_767

    mRNA and Protein(s)

    1. NM_000039.2NP_000030.1  apolipoprotein A-I isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_000030.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform. Variants 1-3 encode the same isoform (1).
      Source sequence(s)
      CD558050, X02162
      Consensus CDS
      CCDS8378.1
      UniProtKB/Swiss-Prot
      P02647
      UniProtKB/TrEMBL
      A0A024R3E3
      Related
      ENSP00000236850.3, OTTHUMP00000043268, ENST00000236850.4, OTTHUMT00000106281
      Conserved Domains (2) summary
      pfam01442
      Location:74242
      Apolipoprotein; Apolipoprotein A1/A4/E domain
      cl00489
      Location:108146
      60KD_IMP; 60Kd inner membrane protein
    2. NM_001318017.1NP_001304946.1  apolipoprotein A-I isoform 1 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same isoform (1).
      Source sequence(s)
      AL557908, AP006216, X02162
      Consensus CDS
      CCDS8378.1
      UniProtKB/Swiss-Prot
      P02647
      UniProtKB/TrEMBL
      A0A024R3E3
      Related
      ENSP00000364469.1, OTTHUMP00000069346, ENST00000375320.5, OTTHUMT00000142222
      Conserved Domains (2) summary
      pfam01442
      Location:74242
      Apolipoprotein; Apolipoprotein A1/A4/E domain
      cl00489
      Location:108146
      60KD_IMP; 60Kd inner membrane protein
    3. NM_001318018.1NP_001304947.1  apolipoprotein A-I isoform 1 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same isoform (1).
      Source sequence(s)
      AL531353, T68127, X02162
      Consensus CDS
      CCDS8378.1
      UniProtKB/Swiss-Prot
      P02647
      UniProtKB/TrEMBL
      A0A024R3E3
      Related
      ENSP00000352471.2, OTTHUMP00000069348, ENST00000359492.6, OTTHUMT00000142224
      Conserved Domains (2) summary
      pfam01442
      Location:74242
      Apolipoprotein; Apolipoprotein A1/A4/E domain
      cl00489
      Location:108146
      60KD_IMP; 60Kd inner membrane protein
    4. NM_001318021.1NP_001304950.1  apolipoprotein A-I isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream translation start site compared to variant 1. The encoded isoform (2) has a shorter N-terminus and lacks a predicted signal peptide compared to isoform 1.
      Source sequence(s)
      BU600916, CD558050, X02162
      UniProtKB/Swiss-Prot
      P02647
      Conserved Domains (1) summary
      pfam01442
      Location:1133
      Apolipoprotein; Apolipoprotein A1/A4/E domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p7 Primary Assembly

      Range
      116835751..116837950 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018922.2 Alternate CHM1_1.1

      Range
      116591219..116593418 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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