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    F2r coagulation factor II (thrombin) receptor [ Mus musculus (house mouse) ]

    Gene ID: 14062, updated on 22-Apr-2017
    Official Symbol
    F2rprovided by MGI
    Official Full Name
    coagulation factor II (thrombin) receptorprovided by MGI
    Primary source
    MGI:MGI:101802
    See related
    Ensembl:ENSMUSG00000048376
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cf2r; Par1; ThrR; AI482343
    Orthologs
    Location:
    13 D1; 13 50.21 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (95601789..95618433, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (96371744..96388388, complement)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene coagulation factor II (thrombin) receptor-like 1 Neighboring gene predicted gene, 32640 Neighboring gene IQ motif containing GTPase activating protein 2 Neighboring gene predicted gene, 33074 Neighboring gene coagulation factor II (thrombin) receptor-like 2

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Homology

    Clone Names

    • MGC28086

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    G-protein alpha-subunit binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    G-protein beta-subunit binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    G-protein coupled receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heterotrimeric G-protein binding TAS
    Traceable Author Statement
    more info
    PubMed 
    receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    signal transducer activity IEA
    Inferred from Electronic Annotation
    more info
     
    thrombin-activated receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    thrombin-activated receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    STAT protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    activation of MAPKK activity ISO
    Inferred from Sequence Orthology
    more info
     
    activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    blood coagulation IEA
    Inferred from Electronic Annotation
    more info
     
    connective tissue replacement involved in inflammatory response wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    establishment of synaptic specificity at neuromuscular junction ISO
    Inferred from Sequence Orthology
    more info
     
    hemostasis IEA
    Inferred from Electronic Annotation
    more info
     
    homeostasis of number of cells within a tissue IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of glomerular filtration ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of renin secretion into blood stream IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phospholipase C-activating G-protein coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    platelet activation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of JAK-STAT cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of Rho protein signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of blood coagulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of blood coagulation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of collagen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-6 secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-8 secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of phosphatidylinositol 3-kinase signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of phosphatidylinositol 3-kinase signaling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of vasoconstriction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of vasoconstriction ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase C-activating G-protein coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of blood coagulation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of interleukin-1 beta production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to wounding ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    thrombin-activated receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    trans-synaptic signaling by endocannabinoid, modulating synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    tyrosine phosphorylation of STAT protein ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    caveola ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    late endosome ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    neuromuscular junction ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    platelet dense tubular network ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    proteinase-activated receptor 1
    Names
    PAR-1
    thrombin receptor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010169.3NP_034299.2  proteinase-activated receptor 1 precursor

      See identical proteins and their annotated locations for NP_034299.2

      Status: PROVISIONAL

      Source sequence(s)
      AC159263, AC164547
      Consensus CDS
      CCDS26701.1
      UniProtKB/Swiss-Prot
      P30558
      Related
      ENSMUSP00000061754.5, ENSMUST00000059193.5
      Conserved Domains (1) summary
      pfam00001
      Location:125376
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

      Range
      95601789..95618433 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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