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    IRF2BP2 interferon regulatory factor 2 binding protein 2 [ Homo sapiens (human) ]

    Gene ID: 359948, updated on 22-Apr-2017
    Official Symbol
    IRF2BP2provided by HGNC
    Official Full Name
    interferon regulatory factor 2 binding protein 2provided by HGNC
    Primary source
    HGNC:HGNC:21729
    See related
    Ensembl:ENSG00000168264 MIM:615332; Vega:OTTHUMG00000037981
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes an interferon regulatory factor-2 (IRF2) binding protein that interacts with the C-terminal transcriptional repression domain of IRF2. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    1q42.3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 1 NC_000001.11 (234604269..234609525, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (234740015..234745271, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1354 Neighboring gene uncharacterized LOC107985465 Neighboring gene long intergenic non-protein coding RNA 184 Neighboring gene uncharacterized LOC101927787 Neighboring gene uncharacterized LOC105373207

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Biological, clinical and population relevance of 95 loci for blood lipids.
    NHGRI GWA Catalog
    Discovery and refinement of loci associated with lipid levels.
    NHGRI GWA Catalog
    Genome-wide association of implantable cardioverter-defibrillator activation with life-threatening arrhythmias.
    NHGRI GWA Catalog
    Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC72189

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
     
    Preferred Names
    interferon regulatory factor 2-binding protein 2
    Names
    IRF-2-binding protein 2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077397.1NP_001070865.1  interferon regulatory factor 2-binding protein 2 isoform B

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform B).
      Source sequence(s)
      AY278024, BC020516, BE408503, CD640986
      Consensus CDS
      CCDS41475.1
      UniProtKB/Swiss-Prot
      Q7Z5L9
      Related
      ENSP00000355569.3, OTTHUMP00000036087, ENST00000366610.7, OTTHUMT00000092704
      Conserved Domains (1) summary
      pfam11261
      Location:1263
      IRF-2BP1_2; Interferon regulatory factor 2-binding protein zinc finger
    2. NM_182972.2NP_892017.2  interferon regulatory factor 2-binding protein 2 isoform A

      See identical proteins and their annotated locations for NP_892017.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (A).
      Source sequence(s)
      AY278023, BC020516, BE408503, CD640986
      Consensus CDS
      CCDS1602.1
      UniProtKB/Swiss-Prot
      Q7Z5L9
      Related
      ENSP00000355568.3, OTTHUMP00000036088, ENST00000366609.3, OTTHUMT00000092705
      Conserved Domains (1) summary
      pfam11261
      Location:1263
      IRF-2BP1_2; Interferon regulatory factor 2-binding protein zinc finger

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p7 Primary Assembly

      Range
      234604269..234609525 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      236012268..236017524 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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