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    Dapk3 death-associated protein kinase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64391, updated on 23-May-2018
    Official Symbol
    Dapk3provided by RGD
    Official Full Name
    death-associated protein kinase 3provided by RGD
    Primary source
    RGD:621766
    See related
    Ensembl:ENSRNOG00000020383
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dapkl
    Summary
    calmodulin (CaM)-regulated protein kinase; may be involved in apoptosis and neuronal development [RGD, Feb 2006]
    Expression
    Biased expression in Heart (RPKM 100.4), Adrenal (RPKM 94.8) and 9 other tissues See more
    Orthologs
    See Dapk3 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (11392436..11400855, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 7 NC_005106.3 (11559842..11568242, complement)

    Chromosome 7 - NC_005106.4Genomic Context describing neighboring genes Neighboring gene ATCAY, caytaxin Neighboring gene nicotinamide riboside kinase 2 Neighboring gene eukaryotic translation elongation factor 2 Neighboring gene uncharacterized LOC102553232

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Autophagy - animal, organism-specific biosystem (from KEGG)
      Autophagy - animal, organism-specific biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • Autophagy - animal, conserved biosystem (from KEGG)
      Autophagy - animal, conserved biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • Bladder cancer, organism-specific biosystem (from KEGG)
      Bladder cancer, organism-specific biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
    • Bladder cancer, conserved biosystem (from KEGG)
      Bladder cancer, conserved biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    Rho GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Rho GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    leucine zipper domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    leucine zipper domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein C-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to interferon-gamma IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to interferon-gamma ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    neuron differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    peptidyl-threonine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of actin cytoskeleton reorganization IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of actin cytoskeleton reorganization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of focal adhesion assembly IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of myosin II filament organization IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of myosin II filament organization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    PML body IEA
    Inferred from Electronic Annotation
    more info
     
    PML body ISO
    Inferred from Sequence Orthology
    more info
     
    actin filament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    death-associated protein kinase 3
    Names
    DAP kinase 3
    DAP-like kinase
    Death-associated like kinase
    MYPT1 kinase
    ZIP-kinase
    dlk
    NP_071991.1
    XP_006241053.1
    XP_006241055.1
    XP_017450587.1
    XP_017450588.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022546.1NP_071991.1  death-associated protein kinase 3

      See identical proteins and their annotated locations for NP_071991.1

      Status: PROVISIONAL

      Source sequence(s)
      AJ006971
      UniProtKB/Swiss-Prot
      O88764
      Related
      ENSRNOP00000027634.5, ENSRNOT00000027634.4
      Conserved Domains (2) summary
      smart00220
      Location:13275
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14105
      Location:7275
      STKc_DAPK; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005106.4 Reference Rnor_6.0 Primary Assembly

      Range
      11392436..11400855 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017595098.1XP_017450587.1  death-associated protein kinase 3 isoform X2

      UniProtKB/Swiss-Prot
      O88764
      Conserved Domains (2) summary
      smart00220
      Location:13275
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14105
      Location:7275
      STKc_DAPK; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase
    2. XM_006240991.1XP_006241053.1  death-associated protein kinase 3 isoform X1

      Conserved Domains (2) summary
      smart00220
      Location:29291
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14105
      Location:23291
      STKc_DAPK; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase
    3. XM_006240993.2XP_006241055.1  death-associated protein kinase 3 isoform X2

      See identical proteins and their annotated locations for XP_006241055.1

      UniProtKB/Swiss-Prot
      O88764
      Conserved Domains (2) summary
      smart00220
      Location:13275
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14105
      Location:7275
      STKc_DAPK; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase
    4. XM_017595099.1XP_017450588.1  death-associated protein kinase 3 isoform X2

      UniProtKB/Swiss-Prot
      O88764
      Conserved Domains (2) summary
      smart00220
      Location:13275
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14105
      Location:7275
      STKc_DAPK; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase

    Alternate Rn_Celera

    Genomic

    1. AC_000075.1 Alternate Rn_Celera

      Range
      6712067..6720435 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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