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    Msra methionine sulfoxide reductase A [ Mus musculus (house mouse) ]

    Gene ID: 110265, updated on 25-May-2017
    Official Symbol
    Msraprovided by MGI
    Official Full Name
    methionine sulfoxide reductase Aprovided by MGI
    Primary source
    MGI:MGI:106916
    See related
    Ensembl:ENSMUSG00000054733 Vega:OTTMUSG00000060968
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MSR-A; 2310045J23Rik; 6530413P12Rik
    Orthologs
    Location:
    14 D1; 14 33.36 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (64122621..64455903, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (64741462..65074740, complement)

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930471C04 gene Neighboring gene RIKEN cDNA 9630015K15 gene Neighboring gene protease, serine 52 Neighboring gene predicted gene 17116 Neighboring gene predicted gene, 41176 Neighboring gene Mir124-1 host gene (non-protein coding) Neighboring gene microRNA 124a-1 Neighboring gene microRNA 3078

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Clone Names

    • MGC101976

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptide-methionine (S)-S-oxide reductase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptide-methionine (S)-S-oxide reductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    aging ISO
    Inferred from Sequence Orthology
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    mitochondrial peptide methionine sulfoxide reductase
    Names
    PMSR
    peptide Met(O) reductase
    peptide methionine sulfoxide reductase
    peptide-methionine (S)-S-oxide reductase
    protein-methionine-S-oxide reductase
    NP_001240641.1
    NP_001240643.1
    NP_001240644.1
    NP_001240645.1
    NP_080598.2
    XP_006518492.1
    XP_011243223.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001253712.1NP_001240641.1  mitochondrial peptide methionine sulfoxide reductase isoform 1

      See identical proteins and their annotated locations for NP_001240641.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AK049714, CX200370
      Consensus CDS
      CCDS27209.1
      UniProtKB/Swiss-Prot
      Q9D6Y7
      Conserved Domains (1) summary
      PRK00058
      Location:26228
      PRK00058; methionine sulfoxide reductase A; Provisional
    2. NM_001253714.1NP_001240643.1  mitochondrial peptide methionine sulfoxide reductase isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an in-frame coding exon and encodes a shorter isoform (2), compared to variant 1.
      Source sequence(s)
      BB652761, BC089311, CB953198, CX200370
      UniProtKB/Swiss-Prot
      Q9D6Y7
      Conserved Domains (1) summary
      PRK00058
      Location:26205
      PRK00058; methionine sulfoxide reductase A; Provisional
    3. NM_001253715.1NP_001240644.1  mitochondrial peptide methionine sulfoxide reductase isoform 3

      See identical proteins and their annotated locations for NP_001240644.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an in-frame coding exon and encodes a shorter isoform (3), compared to variant 1.
      Source sequence(s)
      AC134898, AC154332, AC166997
      UniProtKB/Swiss-Prot
      Q9D6Y7
      Conserved Domains (1) summary
      cl00366
      Location:26188
      PMSR; Peptide methionine sulfoxide reductase
    4. NM_001253716.1NP_001240645.1  mitochondrial peptide methionine sulfoxide reductase isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (4) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK018338, BC089311, BY282106, CX200370
      Consensus CDS
      CCDS84147.1
      UniProtKB/Swiss-Prot
      Q9D6Y7
      Related
      ENSMUSP00000147689.1, OTTMUSP00000077369, ENSMUST00000210428.1, OTTMUST00000148986
      Conserved Domains (1) summary
      PRK00058
      Location:4186
      PRK00058; methionine sulfoxide reductase A; Provisional
    5. NM_001347639.1NP_001334568.1  mitochondrial peptide methionine sulfoxide reductase isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The resulting isoform (5) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AA270013, CA323822, CD776038
      Consensus CDS
      CCDS84146.1
      UniProtKB/TrEMBL
      A0A1B0GT40
    6. NM_026322.4NP_080598.2  mitochondrial peptide methionine sulfoxide reductase isoform 1

      See identical proteins and their annotated locations for NP_080598.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      BC089311, CX200370
      Consensus CDS
      CCDS27209.1
      UniProtKB/Swiss-Prot
      Q9D6Y7
      Related
      ENSMUSP00000065754.7, OTTMUSP00000077368, ENSMUST00000067927.8, OTTMUST00000148985
      Conserved Domains (1) summary
      PRK00058
      Location:26228
      PRK00058; methionine sulfoxide reductase A; Provisional

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

      Range
      64122621..64455903 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006518429.2XP_006518492.1  mitochondrial peptide methionine sulfoxide reductase isoform X2

      Related
      ENSMUSP00000148189.1, OTTMUSP00000077371, ENSMUST00000210363.1, OTTMUST00000148990
      Conserved Domains (1) summary
      cl00366
      Location:2164
      PMSR; Peptide methionine sulfoxide reductase
    2. XM_011244921.2XP_011243223.1  mitochondrial peptide methionine sulfoxide reductase isoform X1

      Conserved Domains (1) summary
      PRK00058
      Location:5191
      PRK00058; methionine sulfoxide reductase A; Provisional
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