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    Gucy2c guanylate cyclase 2c [ Mus musculus (house mouse) ]

    Gene ID: 14917, updated on 10-Apr-2018
    Official Symbol
    Gucy2cprovided by MGI
    Official Full Name
    guanylate cyclase 2cprovided by MGI
    Primary source
    MGI:MGI:106903
    See related
    Ensembl:ENSMUSG00000042638 Vega:OTTMUSG00000033823
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gcc; GC-C; AI893437
    Expression
    Biased expression in large intestine adult (RPKM 40.4), colon adult (RPKM 29.3) and 2 other tissues See more
    Orthologs
    See Gucy2c in Genome Data Viewer
    Location:
    6 G1; 6 66.67 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (136697284..136781742, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (136645805..136730263, complement)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene phospholipase B domain containing 1 Neighboring gene predicted gene, 40409 Neighboring gene protein S100-A10 pseudogene Neighboring gene predicted gene, 40411 Neighboring gene histone cluster 4, H4

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC107510

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    adenylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    guanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    guanylate cyclase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    guanylate cyclase activity ISO
    Inferred from Sequence Orthology
    more info
     
    lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphorus-oxygen lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    toxic substance binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cGMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cGMP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cGMP biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cyclic nucleotide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cyclic nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    response to toxic substance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    guanylate cyclase complex, soluble IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    heat-stable enterotoxin receptor
    Names
    STA receptor
    guanylyl cyclase C
    intestinal guanylate cyclase
    NP_001120790.1
    NP_659504.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127318.1NP_001120790.1  heat-stable enterotoxin receptor isoform 1 precursor

      See identical proteins and their annotated locations for NP_001120790.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and and encodes the longer isoform (1).
      Source sequence(s)
      AK136496, CF353627
      Consensus CDS
      CCDS51941.1
      UniProtKB/Swiss-Prot
      Q3UWA6
      Related
      ENSMUSP00000032338.7, OTTMUSP00000046000, ENSMUST00000032338.9, OTTMUST00000085207
      Conserved Domains (5) summary
      smart00044
      Location:787978
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      smart00221
      Location:502744
      STYKc; Protein kinase; unclassified specificity
      pfam00211
      Location:8141001
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      cl10011
      Location:35415
      Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
      cl21453
      Location:480749
      PKc_like; Protein Kinases, catalytic domain
    2. NM_145067.3NP_659504.2  heat-stable enterotoxin receptor isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AK136496, CF353627
      Consensus CDS
      CCDS20653.1
      UniProtKB/Swiss-Prot
      Q3UWA6
      Related
      ENSMUSP00000077236.6, OTTMUSP00000046002, ENSMUST00000078095.10, OTTMUST00000085209
      Conserved Domains (4) summary
      smart00044
      Location:763954
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:790977
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      cl10011
      Location:35415
      Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
      cl21453
      Location:480725
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      136697284..136781742 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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