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    Vamp7 vesicle-associated membrane protein 7 [ Mus musculus (house mouse) ]

    Gene ID: 20955, updated on 22-Apr-2017
    Official Symbol
    Vamp7provided by MGI
    Official Full Name
    vesicle-associated membrane protein 7provided by MGI
    Primary source
    MGI:MGI:1096399
    See related
    Ensembl:ENSMUSG00000051412
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sybl1; VAMP-7; TI-VAMP
    Orthologs
    Location:
    X; X
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) X Unlocalized Scaffold NT_165789.2 (10737..39191, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X Unlocalized Scaffold NT_165789.2 (10738..39148, complement)

    NT_165789.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105243599 Neighboring gene sprouty homolog 3 (Drosophila) Neighboring gene trimethyllysine hydroxylase, epsilon Neighboring gene RAD9-HUS1-RAD1 interacting nuclear orphan 1 pseudogene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    SNAP receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    syntaxin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    ER to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
     
    ER to Golgi vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Golgi to plasma membrane protein transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    SNARE complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium ion regulated exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion regulated exocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    endosome to lysosome transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    endosome to lysosome transport ISO
    Inferred from Sequence Orthology
    more info
     
    endosome to lysosome transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    eosinophil degranulation ISO
    Inferred from Sequence Orthology
    more info
     
    eosinophil degranulation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    natural killer cell degranulation ISO
    Inferred from Sequence Orthology
    more info
     
    neutrophil degranulation ISO
    Inferred from Sequence Orthology
    more info
     
    neutrophil degranulation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    phagocytosis, engulfment ISO
    Inferred from Sequence Orthology
    more info
     
    phagocytosis, engulfment ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    positive regulation of dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of histamine secretion by mast cell ISO
    Inferred from Sequence Orthology
    more info
     
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of protein targeting to vacuolar membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transport IEA
    Inferred from Electronic Annotation
    more info
     
    triglyceride transport ISO
    Inferred from Sequence Orthology
    more info
     
    vesicle fusion ISO
    Inferred from Sequence Orthology
    more info
     
    vesicle fusion ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    vesicle fusion with Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    vesicle transport along microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
     
    vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    SNARE complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    SNARE complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    apical part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    azurophil granule membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    endosome IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    late endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    late endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    lysosomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phagocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    platelet alpha granule ISO
    Inferred from Sequence Orthology
    more info
     
    pseudopodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    pseudopodium ISO
    Inferred from Sequence Orthology
    more info
     
    secretory granule ISO
    Inferred from Sequence Orthology
    more info
     
    secretory granule membrane ISO
    Inferred from Sequence Orthology
    more info
     
    synapse IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     
    transport vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    vesicle-associated membrane protein 7
    Names
    synaptobrevin like 1
    synaptobrevin-like protein 1
    tetanus neurotoxin-insensitive vesicle-associated membrane protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302138.1NP_001289067.1  vesicle-associated membrane protein 7 isoform 2

      See identical proteins and their annotated locations for NP_001289067.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK002825, AK165299, BP768744
      UniProtKB/Swiss-Prot
      P70280
      Conserved Domains (3) summary
      cd15871
      Location:85149
      R-SNARE_VAMP7; SNARE motif of VAMP7
      pfam00957
      Location:83151
      Synaptobrevin; Synaptobrevin
      pfam13774
      Location:1059
      Longin; Regulated-SNARE-like domain
    2. NM_011515.5NP_035645.1  vesicle-associated membrane protein 7 isoform 1

      See identical proteins and their annotated locations for NP_035645.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK002825, AK165299, BP768744
      UniProtKB/Swiss-Prot
      P70280
      Related
      ENSMUSP00000052262.6, ENSMUST00000051100.6
      Conserved Domains (3) summary
      cd15871
      Location:124188
      R-SNARE_VAMP7; SNARE motif of VAMP7
      pfam00957
      Location:122190
      Synaptobrevin; Synaptobrevin
      pfam13774
      Location:2998
      Longin; Regulated-SNARE-like domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NT_165789.2 Reference GRCm38.p4 C57BL/6J

      Range
      10737..39191 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249809.2XP_011248111.1  vesicle-associated membrane protein 7 isoform X1

      See identical proteins and their annotated locations for XP_011248111.1

      Conserved Domains (3) summary
      cd15871
      Location:85149
      R-SNARE_VAMP7; SNARE motif of VAMP7
      pfam00957
      Location:83151
      Synaptobrevin; Synaptobrevin
      pfam13774
      Location:1059
      Longin; Regulated-SNARE-like domain
    2. XM_006535856.3XP_006535919.1  vesicle-associated membrane protein 7 isoform X2

      Conserved Domains (2) summary
      cd15871
      Location:2387
      R-SNARE_VAMP7; SNARE motif of VAMP7
      pfam00957
      Location:2189
      Synaptobrevin; Synaptobrevin
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