Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    daf-12 Nuclear hormone receptor family member daf-12 [ Caenorhabditis elegans ]

    Gene ID: 181263, updated on 26-Apr-2017
    Gene symbol
    daf-12
    Gene description
    Nuclear hormone receptor family member daf-12
    Primary source
    WormBase:WBGene00000908
    Locus tag
    CELE_F11A1.3
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    See daf-12 in Map Viewer
    Location:
    chromosome: X
    Exon count:
    18
    Sequence:
    Chromosome: X; NC_003284.9 (10644440..10665481)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene hypothetical protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene hypothetical protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA Neighboring gene tRNA

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Dauer formation, organism-specific biosystem (from WikiPathways)
      Dauer formation, organism-specific biosystemFrom wormbook: In response to harsh environmental conditions, C. elegans larvae undergo dauer arrest at the second molt. The past decade has yielded many insights into the signaling pathways and the ...
    • Heterochronic gene regulation of development, organism-specific biosystem (from WikiPathways)
      Heterochronic gene regulation of development, organism-specific biosystem"The heterochronic gene pathway of Caenorhabditis elegans. The heterochronic pathway regulating larval development is shown. The arrows indicate activation; bars indicate repression. Regulatory relat...
    • Longevity regulating pathway - worm, organism-specific biosystem (from KEGG)
      Longevity regulating pathway - worm, organism-specific biosystemThe nematode Caenorhabditis elegans has proven to be a very useful tool for studying the genetics of longevity due to its simple biology. Over 70 genes have been found to influence lifespan in this w...
    • Longevity regulating pathway - worm, conserved biosystem (from KEGG)
      Longevity regulating pathway - worm, conserved biosystemThe nematode Caenorhabditis elegans has proven to be a very useful tool for studying the genetics of longevity due to its simple biology. Over 70 genes have been found to influence lifespan in this w...
    • Metapathway Signal Transduction, organism-specific biosystem (from WikiPathways)
      Metapathway Signal Transduction, organism-specific biosystem
      Metapathway Signal Transduction
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor activity, sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor activity, sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    chemotaxis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    chemotaxis to cAMP IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    dauer entry IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    dauer larval development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    detection of chemical stimulus IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    determination of adult lifespan IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    determination of adult lifespan IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    heat acclimation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    NOT heat acclimation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    lipid storage IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    male mating behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    nematode larval development IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    positive regulation of dauer larval development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of dauer larval development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of development, heterochronic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of pharyngeal pumping IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    response to biotin IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    response to inorganic substance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    steroid hormone mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Names
    Nuclear hormone receptor family member daf-12
    NP_001024547.1
    • Confirmed by transcript evidence
    NP_001024548.1
    • Confirmed by transcript evidence
    NP_001024549.1
    • Confirmed by transcript evidence
    NP_001041239.1
    • Confirmed by transcript evidence

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      10644440..10665481
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029376.4NP_001024547.1  Nuclear hormone receptor family member daf-12 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024547.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EFF5
      Conserved Domains (2) summary
      cd06929
      Location:548733
      NR_LBD_F1; Ligand-binding domain of nuclear receptor family 1
      cd06966
      Location:116209
      NR_DBD_CAR; DNA-binding domain of constitutive androstane receptor (CAR) is composed of two C4-type zinc fingers
    2. NM_001047774.2NP_001041239.1  Nuclear hormone receptor family member daf-12 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001041239.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EFF5
      Conserved Domains (2) summary
      cd06929
      Location:514699
      NR_LBD_F1; Ligand-binding domain of nuclear receptor family 1
      cd06966
      Location:82175
      NR_DBD_CAR; DNA-binding domain of constitutive androstane receptor (CAR) is composed of two C4-type zinc fingers
    3. NM_001029377.3NP_001024548.1  Nuclear hormone receptor family member daf-12 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024548.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EFF5
      Conserved Domains (2) summary
      cd06929
      Location:489674
      NR_LBD_F1; Ligand-binding domain of nuclear receptor family 1
      cd06966
      Location:57150
      NR_DBD_CAR; DNA-binding domain of constitutive androstane receptor (CAR) is composed of two C4-type zinc fingers
    4. NM_001029378.1NP_001024549.1  Nuclear hormone receptor family member daf-12 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024549.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EFF5
      Conserved Domains (1) summary
      cd06929
      Location:62247
      NR_LBD_F1; Ligand-binding domain of nuclear receptor family 1
    Support Center