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    Ntn1 netrin 1 [ Mus musculus (house mouse) ]

    Gene ID: 18208, updated on 19-Nov-2017
    Official Symbol
    Ntn1provided by MGI
    Official Full Name
    netrin 1provided by MGI
    Primary source
    MGI:MGI:105088
    See related
    Ensembl:ENSMUSG00000020902 Vega:OTTMUSG00000005943
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI561871; BC019633; Netrin-1
    Orthologs
    Location:
    11; 11 B3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (68209364..68386826, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (68022866..68200328, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 52 Neighboring gene syntaxin 8 Neighboring gene ribosomal protein L31 pseudogene Neighboring gene microRNA 6406 Neighboring gene predicted gene, 31954 Neighboring gene predicted gene, 32046

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    Cdc42 protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    anterior/posterior axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    axon guidance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    axonogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell adhesion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    inner ear morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mammary gland development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    mammary gland duct morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of axon extension IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nuclear migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of axon extension IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of axon extension ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell motility ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    substrate-dependent cell migration, cell extension ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    basement membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell periphery ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    proteinaceous extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008744.2NP_032770.2  netrin-1 precursor

      See identical proteins and their annotated locations for NP_032770.2

      Status: VALIDATED

      Source sequence(s)
      AI840271, AL669842, BE652257, CF537666, CF585515, U65418
      Consensus CDS
      CCDS24864.1
      UniProtKB/Swiss-Prot
      O09118
      Related
      ENSMUSP00000021284.2, ENSMUST00000021284.3
      Conserved Domains (4) summary
      smart00136
      Location:46283
      LamNT; Laminin N-terminal domain (domain VI)
      cd00055
      Location:284329
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd03579
      Location:487601
      NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...
      pfam00053
      Location:404441
      Laminin_EGF; Laminin EGF domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      68209364..68386826 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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