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    Pitx1 paired-like homeodomain transcription factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 18740, updated on 4-Jun-2017
    Official Symbol
    Pitx1provided by MGI
    Official Full Name
    paired-like homeodomain transcription factor 1provided by MGI
    Primary source
    MGI:MGI:107374
    See related
    Ensembl:ENSMUSG00000021506 Vega:OTTMUSG00000037718
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bft; Potx; Ptx1; P-OTX
    Orthologs
    Location:
    13 B1; 13 30.06 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (55825044..55836193, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (55926415..55932786, complement)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 Neighboring gene RIKEN cDNA 4930451E10 gene Neighboring gene cation channel, sperm associated 3 Neighboring gene predicted gene, 31542 Neighboring gene H2A histone family, member Y Neighboring gene predicted gene, 31485

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    branchiomeric skeletal muscle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cartilage development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic hindlimb morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    embryonic hindlimb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hindlimb morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hindlimb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    myoblast fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    pituitary gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    skeletal system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    pituitary homeobox 1
    Names
    hindlimb-expressed homeobox protein backfoot
    homeobox protein P-OTX
    homeobox protein PITX1
    pituitary OTX-related factor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011097.2NP_035227.1  pituitary homeobox 1

      See identical proteins and their annotated locations for NP_035227.1

      Status: PROVISIONAL

      Source sequence(s)
      AC129780
      Consensus CDS
      CCDS26556.1
      UniProtKB/Swiss-Prot
      P70314
      UniProtKB/TrEMBL
      Q3UQH0
      Related
      ENSMUSP00000021968.5, OTTMUSP00000054634, ENSMUST00000021968.6, OTTMUST00000097411
      Conserved Domains (4) summary
      pfam08430
      Location:204275
      Forkhead_N; Forkhead N-terminal region
      pfam00046
      Location:94146
      Homeobox; Homeobox domain
      pfam03826
      Location:277294
      OAR; OAR domain
      cl19886
      Location:48109
      Cnd2; Condensin complex subunit 2

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

      Range
      55825044..55836193 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517157.3XP_006517220.1  pituitary homeobox 1 isoform X1

      See identical proteins and their annotated locations for XP_006517220.1

      UniProtKB/Swiss-Prot
      P70314
      UniProtKB/TrEMBL
      Q3UQH0
      Conserved Domains (4) summary
      pfam08430
      Location:204275
      Forkhead_N; Forkhead N-terminal region
      pfam00046
      Location:94146
      Homeobox; Homeobox domain
      pfam03826
      Location:277294
      OAR; OAR domain
      cl19886
      Location:48109
      Cnd2; Condensin complex subunit 2
    2. XM_006517158.3XP_006517221.1  pituitary homeobox 1 isoform X1

      See identical proteins and their annotated locations for XP_006517221.1

      UniProtKB/Swiss-Prot
      P70314
      UniProtKB/TrEMBL
      Q3UQH0
      Conserved Domains (4) summary
      pfam08430
      Location:204275
      Forkhead_N; Forkhead N-terminal region
      pfam00046
      Location:94146
      Homeobox; Homeobox domain
      pfam03826
      Location:277294
      OAR; OAR domain
      cl19886
      Location:48109
      Cnd2; Condensin complex subunit 2
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