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    ATP2B2 ATPase plasma membrane Ca2+ transporting 2 [ Homo sapiens (human) ]

    Gene ID: 491, updated on 20-Apr-2017
    Official Symbol
    ATP2B2provided by HGNC
    Official Full Name
    ATPase plasma membrane Ca2+ transporting 2provided by HGNC
    Primary source
    HGNC:HGNC:815
    See related
    Ensembl:ENSG00000157087 MIM:108733; Vega:OTTHUMG00000128679
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PMCA2; PMCA2a; PMCA2i
    Summary
    The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 2. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    3p25.3
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 3 NC_000003.12 (10324023..10707962, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (10365707..10733131, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ghrelin opposite strand/antisense RNA Neighboring gene ghrelin and obestatin prepropeptide Neighboring gene SEC13 homolog, nuclear pore and COPII coat complex component Neighboring gene microRNA 378b Neighboring gene microRNA 885 Neighboring gene ATP2B2 intronic transcript 2 Neighboring gene long intergenic non-protein coding RNA 606 Neighboring gene solute carrier family 6 member 11 Neighboring gene uncharacterized LOC105376950

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Deafness, autosomal recessive 12 Compare labs

    NHGRI GWAS Catalog

    Description
    Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum.
    NHGRI GWA Catalog
    Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
    NHGRI GWA Catalog
    • Adrenergic signaling in cardiomyocytes, organism-specific biosystem (from KEGG)
      Adrenergic signaling in cardiomyocytes, organism-specific biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
    • Adrenergic signaling in cardiomyocytes, conserved biosystem (from KEGG)
      Adrenergic signaling in cardiomyocytes, conserved biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
    • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
      Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
    • Calcium signaling pathway, organism-specific biosystem (from KEGG)
      Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Calcium signaling pathway, conserved biosystem (from KEGG)
      Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Cardiac conduction, organism-specific biosystem (from REACTOME)
      Cardiac conduction, organism-specific biosystemThe normal sequence of contraction of atria and ventricles of the heart require activation of groups of cardiac cells. The mechanism must elicit rapid changes in heart rate and respond to changes in ...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Ion channel transport, organism-specific biosystem (from REACTOME)
      Ion channel transport, organism-specific biosystemIon channels mediate the flow of ions across the plasma membrane of cells. They are integral membrane proteins, typically a multimer of proteins, which, when arranged in the membrane, create a pore f...
    • Ion homeostasis, organism-specific biosystem (from REACTOME)
      Ion homeostasis, organism-specific biosystemIon channel homeostasis in relation to cardiac conduction is described in this section (Couette et al. 2006, Bartos et al. 2015).
    • Ion transport by P-type ATPases, organism-specific biosystem (from REACTOME)
      Ion transport by P-type ATPases, organism-specific biosystemThe P-type ATPases (E1-E2 ATPases) are a large group of evolutionarily related ion pumps that are found in bacteria, archaea and eukaryotes. They are referred to as P-type ATPases because they catal...
    • Muscle contraction, organism-specific biosystem (from REACTOME)
      Muscle contraction, organism-specific biosystemIn this module, the processes by which calcium binding triggers actin - myosin interactions and force generation in smooth and striated muscle tissues are annotated.
    • Pancreatic secretion, organism-specific biosystem (from KEGG)
      Pancreatic secretion, organism-specific biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
    • Pancreatic secretion, conserved biosystem (from KEGG)
      Pancreatic secretion, conserved biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
    • Platelet calcium homeostasis, organism-specific biosystem (from REACTOME)
      Platelet calcium homeostasis, organism-specific biosystemCa2+ homeostasis is controlled by processes that elevate or counter the elevation of cytosolic Ca2+. During steady state conditions, cytoplasmic Ca2+ is reduced by the accumulation of Ca2+ in intrac...
    • Platelet homeostasis, organism-specific biosystem (from REACTOME)
      Platelet homeostasis, organism-specific biosystemUnder normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhesion and activation, suppresses coagulation, enhances fibrin cleavage and is anti-inflammatory in charact...
    • Reduction of cytosolic Ca++ levels, organism-specific biosystem (from REACTOME)
      Reduction of cytosolic Ca++ levels, organism-specific biosystemDuring steady state conditions, cytoplasmic [Ca2+] is reduced by the accumulation of Ca2+ in intracellular stores and Ca2+ extrusion.
    • Salivary secretion, organism-specific biosystem (from KEGG)
      Salivary secretion, organism-specific biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
    • Salivary secretion, conserved biosystem (from KEGG)
      Salivary secretion, conserved biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
    • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
      Transmembrane transport of small molecules, organism-specific biosystem
      Transmembrane transport of small molecules
    • cAMP signaling pathway, organism-specific biosystem (from KEGG)
      cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
    • cAMP signaling pathway, conserved biosystem (from KEGG)
      cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
    • cGMP-PKG signaling pathway, organism-specific biosystem (from KEGG)
      cGMP-PKG signaling pathway, organism-specific biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
    • cGMP-PKG signaling pathway, conserved biosystem (from KEGG)
      cGMP-PKG signaling pathway, conserved biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    PDZ domain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    calcium-dependent ATPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    calcium-transporting ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    calcium-transporting ATPase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    calcium-transporting ATPase activity TAS
    Traceable Author Statement
    more info
     
    calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    ATP hydrolysis coupled cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    auditory receptor cell stereocilium organization IEA
    Inferred from Electronic Annotation
    more info
     
    cGMP metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cerebellar Purkinje cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cerebellar granule cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cochlea development IEA
    Inferred from Electronic Annotation
    more info
     
    detection of mechanical stimulus involved in sensory perception of sound IEA
    Inferred from Electronic Annotation
    more info
     
    ion transmembrane transport TAS
    Traceable Author Statement
    more info
     
    lactation IEA
    Inferred from Electronic Annotation
    more info
     
    locomotion IEA
    Inferred from Electronic Annotation
    more info
     
    locomotory behavior IEA
    Inferred from Electronic Annotation
    more info
     
    neuromuscular process controlling balance IEA
    Inferred from Electronic Annotation
    more info
     
    neuron differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    organelle organization IEA
    Inferred from Electronic Annotation
    more info
     
    otolith mineralization IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cardiac conduction TAS
    Traceable Author Statement
    more info
     
    regulation of cell size IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cytosolic calcium ion concentration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of synaptic plasticity IEA
    Inferred from Electronic Annotation
    more info
     
    sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    serotonin metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    synapse organization IEA
    Inferred from Electronic Annotation
    more info
     
    transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cilium IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    synapse IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    plasma membrane calcium-transporting ATPase 2
    Names
    ATPase, Ca++ transporting, plasma membrane 2
    plasma membrane Ca(2+)-ATPase
    plasma membrane Ca2+ pump 2
    plasma membrane calcium ATPase
    plasma membrane calcium pump
    NP_001001331.1
    NP_001674.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012046.1 RefSeqGene

      Range
      5001..186562
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001001331.2NP_001001331.1  plasma membrane calcium-transporting ATPase 2 isoform 1

      See identical proteins and their annotated locations for NP_001001331.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1), also known as WB.
      Source sequence(s)
      AB210008, AC022384, AK308898, S95738, X63575
      Consensus CDS
      CCDS33701.1
      UniProtKB/Swiss-Prot
      Q01814
      UniProtKB/TrEMBL
      A0A024R2K6, Q4J699, Q4LE63
      Related
      ENSP00000353414.2, ENST00000360273.6
      Conserved Domains (7) summary
      TIGR01517
      Location:121087
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:161488
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:9031081
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:51113
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12424
      Location:11261173
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      pfam12710
      Location:690829
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:549638
      Cation_ATPase; Cation transport ATPase (P-type)
    2. NM_001330611.1NP_001317540.1  plasma membrane calcium-transporting ATPase 2 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks three in-frame exons in the 5' coding region, and contains two additional exons in the 3' coding regions, resulting in novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 3, which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC018839, AC022384, AC090841
      Consensus CDS
      CCDS82733.1
      UniProtKB/Swiss-Prot
      Q01814
    3. NM_001683.3NP_001674.2  plasma membrane calcium-transporting ATPase 2 isoform 2

      See identical proteins and their annotated locations for NP_001674.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks three in-frame exons, compared to variant 1. The encoded isoform (2), also known as ZB, is shorter, compared to isoform 1.
      Source sequence(s)
      AB210008, AC022384, AK308898, X63575
      Consensus CDS
      CCDS2601.1
      UniProtKB/Swiss-Prot
      Q01814
      UniProtKB/TrEMBL
      A0A024R2E4, Q4LE63
      Related
      ENSP00000373311.4, OTTHUMP00000178534, ENST00000383800.8, OTTHUMT00000276086
      Conserved Domains (7) summary
      TIGR01517
      Location:121042
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:161443
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:8581036
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:51113
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12424
      Location:10811128
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      pfam12710
      Location:645784
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:504593
      Cation_ATPase; Cation transport ATPase (P-type)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p7 Primary Assembly

      Range
      10324023..10707962 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017006484.1XP_016861973.1  plasma membrane calcium-transporting ATPase 2 isoform X2

      UniProtKB/Swiss-Prot
      Q01814
      Conserved Domains (7) summary
      TIGR01517
      Location:121056
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:161457
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:8721050
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:51113
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12424
      Location:10951142
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      pfam12710
      Location:659798
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:518607
      Cation_ATPase; Cation transport ATPase (P-type)
    2. XM_006713175.3XP_006713238.1  plasma membrane calcium-transporting ATPase 2 isoform X1

      See identical proteins and their annotated locations for XP_006713238.1

      UniProtKB/Swiss-Prot
      Q01814
      UniProtKB/TrEMBL
      A0A024R2K6
      Conserved Domains (7) summary
      TIGR01517
      Location:121087
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:161488
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:9031081
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:51113
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12424
      Location:11261173
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      pfam12710
      Location:690829
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:549638
      Cation_ATPase; Cation transport ATPase (P-type)
    3. XM_017006487.1XP_016861976.1  plasma membrane calcium-transporting ATPase 2 isoform X5

      UniProtKB/TrEMBL
      A0A024R2E4, Q4LE63
      Related
      ENSP00000380267.1, OTTHUMP00000178537, ENST00000397077.5, OTTHUMT00000276089
      Conserved Domains (7) summary
      TIGR01517
      Location:121042
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:161443
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:8581036
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:51113
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12424
      Location:10811128
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      pfam12710
      Location:645784
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:504593
      Cation_ATPase; Cation transport ATPase (P-type)
    4. XM_017006481.1XP_016861970.1  plasma membrane calcium-transporting ATPase 2 isoform X1

      UniProtKB/Swiss-Prot
      Q01814
      UniProtKB/TrEMBL
      A0A024R2K6
      Conserved Domains (7) summary
      TIGR01517
      Location:121087
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:161488
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:9031081
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:51113
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12424
      Location:11261173
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      pfam12710
      Location:690829
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:549638
      Cation_ATPase; Cation transport ATPase (P-type)
    5. XM_005265179.4XP_005265236.1  plasma membrane calcium-transporting ATPase 2 isoform X1

      See identical proteins and their annotated locations for XP_005265236.1

      UniProtKB/Swiss-Prot
      Q01814
      UniProtKB/TrEMBL
      A0A024R2K6
      Conserved Domains (7) summary
      TIGR01517
      Location:121087
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:161488
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:9031081
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:51113
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12424
      Location:11261173
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      pfam12710
      Location:690829
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:549638
      Cation_ATPase; Cation transport ATPase (P-type)
    6. XM_011533752.2XP_011532054.1  plasma membrane calcium-transporting ATPase 2 isoform X1

      See identical proteins and their annotated locations for XP_011532054.1

      UniProtKB/Swiss-Prot
      Q01814
      UniProtKB/TrEMBL
      A0A024R2K6
      Related
      ENSP00000324172.5, OTTHUMP00000158863, ENST00000352432.8, OTTHUMT00000250576
      Conserved Domains (7) summary
      TIGR01517
      Location:121087
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:161488
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:9031081
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:51113
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12424
      Location:11261173
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      pfam12710
      Location:690829
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:549638
      Cation_ATPase; Cation transport ATPase (P-type)
    7. XM_017006485.1XP_016861974.1  plasma membrane calcium-transporting ATPase 2 isoform X3

      Conserved Domains (7) summary
      TIGR01517
      Location:121087
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:161488
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:9031081
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:51113
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12424
      Location:11261190
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      pfam12710
      Location:690829
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:549638
      Cation_ATPase; Cation transport ATPase (P-type)
    8. XM_017006486.1XP_016861975.1  plasma membrane calcium-transporting ATPase 2 isoform X4

      UniProtKB/Swiss-Prot
      Q01814
      Conserved Domains (7) summary
      TIGR01517
      Location:121087
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:161488
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:9031081
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:51113
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12424
      Location:11261190
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      pfam12710
      Location:690829
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:549638
      Cation_ATPase; Cation transport ATPase (P-type)
    9. XM_017006492.1XP_016861981.1  plasma membrane calcium-transporting ATPase 2 isoform X10

    10. XM_017006483.1XP_016861972.1  plasma membrane calcium-transporting ATPase 2 isoform X2

      UniProtKB/Swiss-Prot
      Q01814
      Related
      ENSP00000414854.1, OTTHUMP00000178535, ENST00000452124.1, OTTHUMT00000276087
      Conserved Domains (7) summary
      TIGR01517
      Location:121056
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:161457
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:8721050
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:51113
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12424
      Location:10951142
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      pfam12710
      Location:659798
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:518607
      Cation_ATPase; Cation transport ATPase (P-type)
    11. XM_017006482.1XP_016861971.1  plasma membrane calcium-transporting ATPase 2 isoform X1

      UniProtKB/Swiss-Prot
      Q01814
      UniProtKB/TrEMBL
      A0A024R2K6
      Conserved Domains (7) summary
      TIGR01517
      Location:121087
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:161488
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:9031081
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:51113
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12424
      Location:11261173
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      pfam12710
      Location:690829
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:549638
      Cation_ATPase; Cation transport ATPase (P-type)
    12. XM_017006491.1XP_016861980.1  plasma membrane calcium-transporting ATPase 2 isoform X9

      Related
      ENSP00000424494.1, OTTHUMP00000222615, ENST00000460129.5, OTTHUMT00000276088
    13. XM_017006489.1XP_016861978.1  plasma membrane calcium-transporting ATPase 2 isoform X7

      UniProtKB/Swiss-Prot
      Q01814
    14. XM_017006490.1XP_016861979.1  plasma membrane calcium-transporting ATPase 2 isoform X8

    15. XM_017006488.1XP_016861977.1  plasma membrane calcium-transporting ATPase 2 isoform X6

      Conserved Domains (7) summary
      TIGR01517
      Location:121056
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:161457
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:8721050
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:51113
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12424
      Location:10951159
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      pfam12710
      Location:659798
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:518607
      Cation_ATPase; Cation transport ATPase (P-type)

    Alternate CHM1_1.1

    Genomic

    1. NC_018914.2 Alternate CHM1_1.1

      Range
      10315744..10497280 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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