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    Thrb thyroid hormone receptor beta [ Mus musculus (house mouse) ]

    Gene ID: 21834, updated on 22-Nov-2017
    Official Symbol
    Thrbprovided by MGI
    Official Full Name
    thyroid hormone receptor betaprovided by MGI
    Primary source
    MGI:MGI:98743
    See related
    Ensembl:ENSMUSG00000021779 Vega:OTTMUSG00000023243
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nr1a2; Thrb1; Thrb2; T3R[b]; T3Rbeta; c-erbAbeta
    Expression
    Broad expression in cortex adult (RPKM 2.1), adrenal adult (RPKM 2.1) and 24 other tissues See more
    Orthologs
    Location:
    14; 14 A2
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (17659219..18040097)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (18493474..18870602)

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 32121 Neighboring gene predicted gene, 32187 Neighboring gene predicted gene, 32269 Neighboring gene NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC141269, MGC141270

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA binding transcription factor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    chromatin DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    steroid hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    thyroid hormone binding ISO
    Inferred from Sequence Orthology
    more info
     
    thyroid hormone receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    thyroid hormone receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    thyroid hormone receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    Type I pneumocyte differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    animal organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    female courtship behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of female receptivity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of chondrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ossification ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of cholesterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of transcription, DNA-templated TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of triglyceride metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    steroid hormone mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with nuclear chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    Preferred Names
    thyroid hormone receptor beta
    Names
    TR beta
    c-erbA-2
    c-erbA-beta
    nuclear receptor subfamily 1 group A member 2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113417.1NP_001106888.1  thyroid hormone receptor beta isoform 1

      See identical proteins and their annotated locations for NP_001106888.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) contains a distinct 5' UTR and multiple 5' coding region differences, compared to variant 2. Codons 1-94 of this variant are encoded by exons that are not present in variant 2. The encoded protein (isoform 1) is identical to isoform 2 in the C-terminus.
      Source sequence(s)
      AC154626, AC154681, AK133662, AK158826
      Consensus CDS
      CCDS49404.1
      UniProtKB/Swiss-Prot
      P37242
      UniProtKB/TrEMBL
      Q3UZT5
      Related
      ENSMUSP00000022303.7, ENSMUST00000022303.14
      Conserved Domains (2) summary
      cd06935
      Location:216458
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:106192
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
    2. NM_009380.3NP_033406.1  thyroid hormone receptor beta isoform 2

      See identical proteins and their annotated locations for NP_033406.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) encodes the longer isoform (2).
      Source sequence(s)
      AC154626, AC154681, BC089035
      Consensus CDS
      CCDS26835.1
      UniProtKB/Swiss-Prot
      P37242
      Related
      ENSMUSP00000022304.8, OTTMUSP00000027025, ENSMUST00000022304.9, OTTMUST00000056280
      Conserved Domains (2) summary
      cd06935
      Location:230472
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:120206
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

      Range
      17659219..18040097
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244741.2XP_011243043.1  thyroid hormone receptor beta isoform X1

      See identical proteins and their annotated locations for XP_011243043.1

      UniProtKB/Swiss-Prot
      P37242
      Conserved Domains (2) summary
      cd06935
      Location:216458
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:106192
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
    2. XM_011244739.2XP_011243041.1  thyroid hormone receptor beta isoform X1

      See identical proteins and their annotated locations for XP_011243041.1

      UniProtKB/Swiss-Prot
      P37242
      Conserved Domains (2) summary
      cd06935
      Location:216458
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:106192
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
    3. XM_006517970.3XP_006518033.1  thyroid hormone receptor beta isoform X1

      See identical proteins and their annotated locations for XP_006518033.1

      UniProtKB/Swiss-Prot
      P37242
      Conserved Domains (2) summary
      cd06935
      Location:216458
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:106192
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
    4. XM_011244737.1XP_011243039.1  thyroid hormone receptor beta isoform X1

      See identical proteins and their annotated locations for XP_011243039.1

      UniProtKB/Swiss-Prot
      P37242
      Conserved Domains (2) summary
      cd06935
      Location:216458
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:106192
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
    5. XM_006517966.2XP_006518029.1  thyroid hormone receptor beta isoform X1

      See identical proteins and their annotated locations for XP_006518029.1

      UniProtKB/Swiss-Prot
      P37242
      Related
      ENSMUSP00000089053.4, OTTMUSP00000027095, ENSMUST00000091471.11, OTTMUST00000056384
      Conserved Domains (2) summary
      cd06935
      Location:216458
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:106192
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
    6. XM_011244745.1XP_011243047.1  thyroid hormone receptor beta isoform X3

      Conserved Domains (2) summary
      cd06935
      Location:185427
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:75161
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
    7. XM_011244742.1XP_011243044.1  thyroid hormone receptor beta isoform X1

      See identical proteins and their annotated locations for XP_011243044.1

      UniProtKB/Swiss-Prot
      P37242
      Conserved Domains (2) summary
      cd06935
      Location:216458
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:106192
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
    8. XM_006517968.3XP_006518031.1  thyroid hormone receptor beta isoform X1

      See identical proteins and their annotated locations for XP_006518031.1

      UniProtKB/Swiss-Prot
      P37242
      Conserved Domains (2) summary
      cd06935
      Location:216458
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:106192
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
    9. XM_006517967.3XP_006518030.1  thyroid hormone receptor beta isoform X1

      See identical proteins and their annotated locations for XP_006518030.1

      UniProtKB/Swiss-Prot
      P37242
      Conserved Domains (2) summary
      cd06935
      Location:216458
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:106192
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
    10. XM_017315947.1XP_017171436.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      P37242
      Conserved Domains (2) summary
      cd06935
      Location:216458
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:106192
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
    11. XM_011244740.2XP_011243042.1  thyroid hormone receptor beta isoform X1

      See identical proteins and their annotated locations for XP_011243042.1

      UniProtKB/Swiss-Prot
      P37242
      Conserved Domains (2) summary
      cd06935
      Location:216458
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:106192
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
    12. XM_011244743.2XP_011243045.1  thyroid hormone receptor beta isoform X1

      See identical proteins and their annotated locations for XP_011243045.1

      UniProtKB/Swiss-Prot
      P37242
      Conserved Domains (2) summary
      cd06935
      Location:216458
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:106192
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
    13. XM_011244738.2XP_011243040.1  thyroid hormone receptor beta isoform X1

      See identical proteins and their annotated locations for XP_011243040.1

      UniProtKB/Swiss-Prot
      P37242
      Conserved Domains (2) summary
      cd06935
      Location:216458
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:106192
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
    14. XM_017315946.1XP_017171435.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      P37242
      Conserved Domains (2) summary
      cd06935
      Location:216458
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:106192
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
    15. XM_006517972.3XP_006518035.1  thyroid hormone receptor beta isoform X1

      See identical proteins and their annotated locations for XP_006518035.1

      UniProtKB/Swiss-Prot
      P37242
      Conserved Domains (2) summary
      cd06935
      Location:216458
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:106192
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
    16. XM_006517971.3XP_006518034.1  thyroid hormone receptor beta isoform X1

      See identical proteins and their annotated locations for XP_006518034.1

      UniProtKB/Swiss-Prot
      P37242
      Conserved Domains (2) summary
      cd06935
      Location:216458
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:106192
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
    17. XM_017315948.1XP_017171437.1  thyroid hormone receptor beta isoform X2

      Conserved Domains (2) summary
      cd06935
      Location:213455
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:103189
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
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