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    Birc5 baculoviral IAP repeat-containing 5 [ Mus musculus (house mouse) ]

    Gene ID: 11799, updated on 12-Jul-2017
    Official Symbol
    Birc5provided by MGI
    Official Full Name
    baculoviral IAP repeat-containing 5provided by MGI
    Primary source
    MGI:MGI:1203517
    See related
    Ensembl:ENSMUSG00000017716 Vega:OTTMUSG00000003737
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Api4; TIAP; AAC-11; survivin40
    Summary
    This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. In humans, gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts have been identified in human that regulate this gene's expression. At least three transcript variants encoding distinct isoforms have been found for this gene, although at least one of these transcript variants is a nonsense-mediated decay (NMD) candidate. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    11; 11 E2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (117849237..117855743)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (117710551..117717057)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene synaptogyrin 2 Neighboring gene thymidine kinase 1 Neighboring gene arylformamidase Neighboring gene transmembrane protein 235 Neighboring gene predicted gene 11725 Neighboring gene threonine aldolase 1

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    Ran GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    chaperone binding ISO
    Inferred from Sequence Orthology
    more info
     
    cofactor binding ISO
    Inferred from Sequence Orthology
    more info
     
    cysteine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    peptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division ISO
    Inferred from Sequence Orthology
    more info
     
    chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
     
    cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    embryo development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment of chromosome localization ISO
    Inferred from Sequence Orthology
    more info
     
    inhibition of cysteine-type endopeptidase activity involved in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of exit from mitosis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex localization ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of insulin secretion involved in cellular response to glucose stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of type B pancreatic cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spindle checkpoint ISO
    Inferred from Sequence Orthology
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    centriole ISO
    Inferred from Sequence Orthology
    more info
     
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome passenger complex ISO
    Inferred from Sequence Orthology
    more info
     
    chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    condensed chromosome kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    interphase microtubule organizing center ISO
    Inferred from Sequence Orthology
    more info
     
    kinetochore IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    midbody ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    spindle microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    baculoviral IAP repeat-containing protein 5
    Names
    apoptosis inhibitor 4
    apoptosis inhibitor survivin
    survivin

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012273.1NP_001012273.1  baculoviral IAP repeat-containing protein 5 isoform 3

      See identical proteins and their annotated locations for NP_001012273.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), also known as survivin121, uses an alternate splice site in the 3' coding region, compared to variant 1, that results in a frameshift. It encodes isoform 3 which has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AB013819, BC004702, BY023910
      Consensus CDS
      CCDS25695.1
      UniProtKB/Swiss-Prot
      O70201
      Related
      ENSMUSP00000091433.4, OTTMUSP00000003967, ENSMUST00000093906.4, OTTMUST00000008141
      Conserved Domains (1) summary
      pfam00653
      Location:1888
      BIR; Inhibitor of Apoptosis domain
    2. NM_009689.2NP_033819.1  baculoviral IAP repeat-containing protein 5 isoform 1

      See identical proteins and their annotated locations for NP_033819.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), also known as survivin140, represents the most frequently occurring transcript and it encodes isoform 1.
      Source sequence(s)
      AB013819, AI413910, CN724527
      Consensus CDS
      CCDS25694.1
      UniProtKB/Swiss-Prot
      O70201
      UniProtKB/TrEMBL
      Q549P2
      Related
      ENSMUSP00000079124.4, OTTMUSP00000003966, ENSMUST00000081387.10, OTTMUST00000008140
      Conserved Domains (1) summary
      pfam00653
      Location:1888
      BIR; Inhibitor of Apoptosis domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      117849237..117855743
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001012272.1: Suppressed sequence

      Description
      NM_001012272.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
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