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    Fmr1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37528, updated on 5-Mar-2017
    Official Symbol
    Fmr1provided by FlyBase
    Primary source
    FLYBASE:FBgn0028734
    Locus tag
    Dmel_CG6203
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster (old-lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AT24755; BcDNA:GM08679; cg6203; CG6203; dfmr; dFMR; dfmr1; dFmr1; dFMR1; dFmrp; dFMRP; DFMRP; dfxr; dFXR; dfxr1; dFXR1; dFXRP; Dmel\CG6203; dmfr1; EP(3)3517; fmr; FMR; fmr1; FMR1; Fmrp; FMRp; FMRP; FXR
    Location:
    85F10-85F12
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.13 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (10101420..10110121, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5927142..5935843, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene mir-277 stem loop Neighboring gene mir-34 stem loop Neighboring gene CG3940 gene product from transcript CG3940-RB Neighboring gene gamma Soluble NSF attachment protein 2

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • RNA transport, organism-specific biosystem (from KEGG)
      RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • RNA transport, conserved biosystem (from KEGG)
      RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein self-association IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    associative learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    axon guidance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    axonal fasciculation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    brain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellularization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellularization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    NOT chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    circadian rhythm TAS
    Traceable Author Statement
    more info
    PubMed 
    circadian sleep/wake cycle, sleep IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    detection of mechanical stimulus involved in sensory perception of touch IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    germ cell development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    germ cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    germ-line cyst formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    germ-line cyst formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    germarium-derived oocyte fate determination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    grooming behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    habituation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heterochromatin assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    larval locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    locomotion TAS
    Traceable Author Statement
    more info
    PubMed 
    locomotor rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mRNA transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    male courtship behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    male courtship behavior TAS
    Traceable Author Statement
    more info
    PubMed 
    medium-term memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic cell cycle, embryonic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mushroom body development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of imaginal disc growth IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of synaptic growth at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of translation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    negative regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuromuscular junction development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron projection morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neurotransmitter secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    olfactory learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    oocyte dorsal/ventral axis specification IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    NOT phototaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    pole cell formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neuroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of mitotic cell cycle, embryonic IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of neuromuscular synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of olfactory learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of synapse organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of synapse organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of synapse structural plasticity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of synaptic growth at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of translation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    short-term memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT short-term memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    social behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sperm axoneme assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    synapse assembly NAS
    Non-traceable Author Statement
    more info
    PubMed 
    synapse organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    synaptic vesicle budding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    synaptic vesicle clustering IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    RISC complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    RISC complex TAS
    Traceable Author Statement
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipid particle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    micro-ribonucleoprotein complex TAS
    Traceable Author Statement
    more info
    PubMed 
    neuronal ribonucleoprotein granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    CG6203 gene product from transcript CG6203-RC
    Names
    CG6203-PA
    CG6203-PB
    CG6203-PC
    CG6203-PD
    CG6203-PE
    CG6203-PF
    CG6203-PG
    CG6203-PH
    CG6203-PI
    CG6203-PJ
    CG6203-PK
    Fmr1
    Fmr1-PA
    Fmr1-PB
    Fmr1-PC
    Fmr1-PD
    Fmr1-PE
    Fmr1-PF
    Fmr1-PG
    Fmr1-PH
    Fmr1-PI
    Fmr1-PJ
    Fmr1-PK
    Fragile-X mental retardation 1
    Fragile-X mental retardation protein
    Fragile-X-related
    dFMR
    dFmr1
    drosophila fragile X mental retardation protein
    fragile X
    fragile X mental retardation
    fragile X mental retardation 1
    fragile X mental retardation gene
    fragile X mental retardation protein
    fragile X mental retardation protein 1
    fragile X protein
    fragile X related protein
    fragile X-related
    fragile x related
    fragile-X
    NP_001247017.1
    • non-AUG (CUG) translation initiation
    NP_001262447.1
    • non-AUG (CUG) translation initiation

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      10101420..10110121 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169324.2NP_731443.1  Fmr1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731443.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9NFU0
      UniProtKB/TrEMBL
      A0A126GUS7
      Related
      FBpp0081676, FBtr0082198
      Conserved Domains (3) summary
      smart00743
      Location:59115
      Agenet; Tudor-like domain present in plant sequences
      pfam00013
      Location:289356
      KH_1; KH domain
      pfam12235
      Location:359480
      FXMRP1_C_core; Fragile X-related 1 protein core C terminal
    2. NM_001260088.1NP_001247017.1  Fmr1, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247017.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K618
      Related
      FBpp0300445, FBtr0308123
      Conserved Domains (3) summary
      smart00743
      Location:107163
      Agenet; Tudor-like domain present in plant sequences
      pfam00013
      Location:337404
      KH_1; KH domain
      pfam12235
      Location:407528
      FXMRP1_C_core; Fragile X-related 1 protein core C terminal
    3. NM_169326.3NP_731445.1  Fmr1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731445.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9NFU0
      Related
      FBpp0081678, FBtr0082200
      Conserved Domains (3) summary
      smart00743
      Location:2177
      Agenet; Tudor-like domain present in plant sequences
      pfam00013
      Location:251318
      KH_1; KH domain
      pfam12235
      Location:321442
      FXMRP1_C_core; Fragile X-related 1 protein core C terminal
    4. NM_001275519.1NP_001262448.1  Fmr1, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262448.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFN9
      Related
      FBpp0307053, FBtr0335049
      Conserved Domains (3) summary
      smart00743
      Location:2177
      Agenet; Tudor-like domain present in plant sequences
      pfam00013
      Location:251314
      KH_1; KH domain
      pfam12235
      Location:317438
      FXMRP1_C_core; Fragile X-related 1 protein core C terminal
    5. NM_001170109.2NP_001163580.1  Fmr1, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163580.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3LF78
      Related
      FBpp0290600, FBtr0301386
      Conserved Domains (3) summary
      smart00743
      Location:2177
      Agenet; Tudor-like domain present in plant sequences
      pfam00013
      Location:251321
      KH_1; KH domain
      pfam12235
      Location:324445
      FXMRP1_C_core; Fragile X-related 1 protein core C terminal
    6. NM_137801.4NP_611645.1  Fmr1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611645.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9NFU0
      Related
      FBpp0081675, FBtr0082197
      Conserved Domains (3) summary
      smart00743
      Location:59115
      Agenet; Tudor-like domain present in plant sequences
      pfam00013
      Location:289359
      KH_1; KH domain
      pfam12235
      Location:362483
      FXMRP1_C_core; Fragile X-related 1 protein core C terminal
    7. NM_001316514.1NP_001303443.1  Fmr1, isoform J [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9NFU0
      UniProtKB/TrEMBL
      A0A126GUS7
      Related
      FBpp0312465, FBtr0347104
      Conserved Domains (3) summary
      smart00743
      Location:59115
      Agenet; Tudor-like domain present in plant sequences
      pfam00013
      Location:289356
      KH_1; KH domain
      pfam12235
      Location:359480
      FXMRP1_C_core; Fragile X-related 1 protein core C terminal
    8. NM_001316515.1NP_001303444.1  Fmr1, isoform K [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9NFU0
      UniProtKB/TrEMBL
      A0A126GUS7
      Related
      FBpp0312466, FBtr0347105
      Conserved Domains (3) summary
      smart00743
      Location:59115
      Agenet; Tudor-like domain present in plant sequences
      pfam00013
      Location:289356
      KH_1; KH domain
      pfam12235
      Location:359480
      FXMRP1_C_core; Fragile X-related 1 protein core C terminal
    9. NM_169325.3NP_731444.1  Fmr1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731444.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9NFU0
      UniProtKB/TrEMBL
      A0A126GUS7
      Related
      FBpp0081677, FBtr0082199
      Conserved Domains (3) summary
      smart00743
      Location:59115
      Agenet; Tudor-like domain present in plant sequences
      pfam00013
      Location:289356
      KH_1; KH domain
      pfam12235
      Location:359480
      FXMRP1_C_core; Fragile X-related 1 protein core C terminal
    10. NM_169327.2NP_731446.1  Fmr1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731446.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9NFU0
      Related
      FBpp0081674, FBtr0082196
      Conserved Domains (4) summary
      smart00743
      Location:59115
      Agenet; Tudor-like domain present in plant sequences
      cd00105
      Location:289350
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam00013
      Location:223282
      KH_1; KH domain
      pfam12235
      Location:352473
      FXMRP1_C_core; Fragile X-related 1 protein core C terminal
    11. NM_001275518.1NP_001262447.1  Fmr1, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262447.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGP6
      Related
      FBpp0307052, FBtr0335048
      Conserved Domains (4) summary
      smart00743
      Location:107163
      Agenet; Tudor-like domain present in plant sequences
      cd00105
      Location:337398
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam00013
      Location:271330
      KH_1; KH domain
      pfam12235
      Location:400521
      FXMRP1_C_core; Fragile X-related 1 protein core C terminal
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