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    Grm1 glutamate receptor, metabotropic 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24414, updated on 8-May-2017
    Official Symbol
    Grm1provided by RGD
    Official Full Name
    glutamate receptor, metabotropic 1provided by RGD
    Primary source
    RGD:2742
    See related
    Ensembl:ENSRNOG00000014290
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gprc1a
    Summary
    may play a role in synaptic transmission; may modulate perception of pain in arthritis [RGD, Feb 2006]
    Orthologs
    Location:
    1p13
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (4753141..5165859, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (6815959..6818380, complement) , (6413420..6685561, complement)

    Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene eukaryotic initiation factor 4A-I-like Neighboring gene androglobin Neighboring gene RAB32, member RAS oncogene family Neighboring gene dynactin 3-like 1 Neighboring gene SNF2 histone linker PHD RING helicase

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    G-protein coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    G-protein coupled receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    PLC activating G-protein coupled glutamate receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    collagen binding IEA
    Inferred from Electronic Annotation
    more info
     
    estrogen receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    fibronectin binding IEA
    Inferred from Electronic Annotation
    more info
     
    glutamate receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    glutamate receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    glutamate receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    glutamate receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    laminin binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    G-protein coupled glutamate receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    G-protein coupled glutamate receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    G-protein coupled glutamate receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    G-protein coupled glutamate receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    G-protein coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    G-protein coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    activation of MAPK activity IEA
    Inferred from Electronic Annotation
    more info
     
    activation of MAPK activity ISO
    Inferred from Sequence Orthology
    more info
     
    activation of MAPKK activity IEA
    Inferred from Electronic Annotation
    more info
     
    activation of MAPKK activity ISO
    Inferred from Sequence Orthology
    more info
     
    adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    calcium-mediated signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to electrical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to electrical stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    chemical synaptic transmission IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    dimeric G-protein coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    dimeric G-protein coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    dimeric G-protein coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    locomotory behavior IEA
    Inferred from Electronic Annotation
    more info
     
    locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
     
    membrane depolarization TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of JAK-STAT cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of establishment of protein localization to plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    phospholipase C-activating G-protein coupled glutamate receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    receptor-mediated virion attachment to host cell IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of glutamate secretion TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of sensory perception of pain IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of synaptic transmission, glutamatergic IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sensory perception of pain IEA
    Inferred from Electronic Annotation
    more info
     
    sensory perception of pain IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic transmission, GABAergic TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    G-protein coupled receptor dimeric complex ISO
    Inferred from Sequence Orthology
    more info
     
    G-protein coupled receptor homodimeric complex IEA
    Inferred from Electronic Annotation
    more info
     
    G-protein coupled receptor homodimeric complex ISO
    Inferred from Sequence Orthology
    more info
     
    axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     
    postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    metabotropic glutamate receptor 1
    Names
    G protein coupled receptor family C group 1 member A
    mGluR1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114330.1NP_001107802.1  metabotropic glutamate receptor 1 isoform beta precursor

      Status: VALIDATED

      Description
      Transcript Variant: his variant (2) encodes the shorter isoform (beta). Isoform beta has a different subcellular distribution than isoform alpha and may be functionally distinct due to differential G-protein coupling of its novel C-terminal sequence.
      Source sequence(s)
      M61099, Y18810
      UniProtKB/Swiss-Prot
      P23385
      UniProtKB/TrEMBL
      Q9WTJ1
      Related
      ENSRNOP00000047790.3, ENSRNOT00000044325.3
      Conserved Domains (4) summary
      cd06374
      Location:36510
      PBP1_mGluR_groupI; Ligand binding domain of the group I metabotropic glutamate receptor
      pfam00003
      Location:604837
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
      pfam01094
      Location:77485
      ANF_receptor; Receptor family ligand binding region
      pfam07562
      Location:521570
      NCD3G; Nine Cysteines Domain of family 3 GPCR
    2. NM_017011.1NP_058707.1  metabotropic glutamate receptor 1 isoform alpha precursor

      See identical proteins and their annotated locations for NP_058707.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (alpha).
      Source sequence(s)
      M61099
      UniProtKB/Swiss-Prot
      P23385
      Related
      ENSRNOP00000019319.1, ENSRNOT00000019319.3
      Conserved Domains (5) summary
      cd06374
      Location:36510
      PBP1_mGluR_groupI; Ligand binding domain of the group I metabotropic glutamate receptor
      pfam00003
      Location:604837
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
      pfam01094
      Location:77485
      ANF_receptor; Receptor family ligand binding region
      pfam07562
      Location:521570
      NCD3G; Nine Cysteines Domain of family 3 GPCR
      pfam10606
      Location:11491199
      GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

      Range
      4753141..5165859 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017588777.1XP_017444266.1  metabotropic glutamate receptor 1 isoform X1

      UniProtKB/TrEMBL
      G3V7U1
      Conserved Domains (5) summary
      cd06374
      Location:36510
      PBP1_mGluR_groupI; Ligand binding domain of the group I metabotropic glutamate receptor
      pfam00003
      Location:604837
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
      pfam01094
      Location:77485
      ANF_receptor; Receptor family ligand binding region
      pfam07562
      Location:521570
      NCD3G; Nine Cysteines Domain of family 3 GPCR
      pfam10606
      Location:11491199
      GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor

    Alternate Rn_Celera

    Genomic

    1. AC_000069.1 Alternate Rn_Celera

      Range
      3589875..3976624 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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