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    HMG2 hydroxymethylglutaryl-CoA reductase (NADPH) HMG2 [ Saccharomyces cerevisiae S288c ]

    Gene ID: 851171, updated on 9-Apr-2017
    Gene symbol
    HMG2
    Gene description
    hydroxymethylglutaryl-CoA reductase (NADPH) HMG2
    Primary source
    SGD:S000004442
    Locus tag
    YLR450W
    Gene type
    protein coding
    RNA name
    hydroxymethylglutaryl-CoA reductase (NADPH) HMG2
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    See HMG2 in Map Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (1032627..1035764)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene ribosomal 60S subunit protein L6B Neighboring gene peptidylprolyl isomerase FPR4 Neighboring gene leucine-responsive transcriptional regulator LEU3 Neighboring gene GTPase-activating protein SST2

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    NADP binding IEA
    Inferred from Electronic Annotation
    more info
     
    coenzyme binding IEA
    Inferred from Electronic Annotation
    more info
     
    hydroxymethylglutaryl-CoA reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydroxymethylglutaryl-CoA reductase (NADPH) activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    hydroxymethylglutaryl-CoA reductase (NADPH) activity ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    coenzyme A metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    ergosterol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ergosterol biosynthetic process ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    isoprenoid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    isoprenoid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    steroid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    steroid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    sterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane ISM
    Inferred from Sequence Model
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear periphery IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    peroxisomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    proteasome complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Names
    hydroxymethylglutaryl-CoA reductase (NADPH) HMG2
    NP_013555.1
    • HMG-CoA reductase; converts HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; one of two isozymes; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks; forms foci at nuclear periphery upon DNA replication stress; HMG2 has a paralog, HMG1, that arose from the whole genome duplication; human homolog HMGCR can complement yeast hmg2 mutant

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      1032627..1035764
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182338.1NP_013555.1  TPA: hydroxymethylglutaryl-CoA reductase (NADPH) HMG2 [Saccharomyces cerevisiae S288c]

      See identical proteins and their annotated locations for NP_013555.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P12684
      Conserved Domains (4) summary
      TIGR00533
      Location:6121021
      HMG_CoA_R_NADP; 3-hydroxy-3-methylglutaryl Coenzyme A reductase, hydroxymethylglutaryl-CoA reductase (NADP)
      TIGR00920
      Location:1951030
      2A060605; 3-hydroxy-3-methylglutaryl-coenzyme A reductase
      pfam13323
      Location:10159
      HPIH; N-terminal domain with HPIH motif
      cl21543
      Location:213356
      MMPL; MMPL family
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