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    Dusp16 dual specificity phosphatase 16 [ Mus musculus (house mouse) ]

    Gene ID: 70686, updated on 12-Mar-2017
    Official Symbol
    Dusp16provided by MGI
    Official Full Name
    dual specificity phosphatase 16provided by MGI
    Primary source
    MGI:MGI:1917936
    See related
    Ensembl:ENSMUSG00000030203 Vega:OTTMUSG00000023267
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MKP7; Mkpm; MKP-7; AW558566; D6Ertd213e; 3830417M17Rik
    Orthologs
    Location:
    6 G1; 6 65.77 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (134715468..134792628, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (134665491..134742646, complement)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene MANSC domain containing 1 Neighboring gene BLOC-1 related complex subunit 5 Neighboring gene predicted gene, 36328 Neighboring gene uncharacterized LOC105242798 Neighboring gene cAMP responsive element binding protein-like 2

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    inactivation of MAPK activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    dual specificity protein phosphatase 16
    Names
    MAP kinase phosphatase-7
    map kinase phosphatase-M
    NP_001041519.1
    NP_569714.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001048054.2NP_001041519.1  dual specificity protein phosphatase 16 isoform B1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (B1) uses an alternate in-frame splice site in the 3' terminal exon, compared to variant A1. It encodes isoform B1, which lacks an internal segment and is shorter, compared to isoform A1.
      Source sequence(s)
      AC122193, AC126692, BE851024, CA751341, CF733313, CN695929, CV557369
      Consensus CDS
      CCDS85175.1
      UniProtKB/TrEMBL
      F6UIK0
      Related
      ENSMUSP00000115925, OTTMUSP00000073677, ENSMUST00000129433, OTTMUST00000140797
      Conserved Domains (2) summary
      cd00127
      Location:158272
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
      cd01446
      Location:10136
      DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
    2. NM_130447.3NP_569714.2  dual specificity protein phosphatase 16 isoform A1

      See identical proteins and their annotated locations for NP_569714.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (A1) represents the longer transcript and encodes the longer isoform (A1).
      Source sequence(s)
      AC122193, AC126692, BC057321
      Consensus CDS
      CCDS39679.1
      UniProtKB/TrEMBL
      Q6PCP3
      Related
      ENSMUSP00000098419, OTTMUSP00000027061, ENSMUST00000100857, OTTMUST00000056331
      Conserved Domains (2) summary
      cd00127
      Location:158295
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
      cd01446
      Location:10136
      DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      134715468..134792628 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_181320.2: Suppressed sequence

      Description
      NM_181320.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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