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    Kat2b K(lysine) acetyltransferase 2B [ Mus musculus (house mouse) ]

    Gene ID: 18519, updated on 25-May-2017
    Official Symbol
    Kat2bprovided by MGI
    Official Full Name
    K(lysine) acetyltransferase 2Bprovided by MGI
    Primary source
    MGI:MGI:1343094
    See related
    Ensembl:ENSMUSG00000000708 Vega:OTTMUSG00000035538
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pcaf; p/CAF; AI461839; AW536563; A930006P13Rik
    Orthologs
    Location:
    17 C; 17 27.86 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (53566842..53672721)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (53706640..53812045)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene tumor protein, translationally-controlled, pseudogene 7 Neighboring gene RAB5A, member RAS oncogene family Neighboring gene protein phosphatase 2C-like domain containing 1 Neighboring gene shugoshin 1 Neighboring gene predicted gene, 31532

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    N-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acetyltransferase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    cyclin-dependent protein serine/threonine kinase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    histone acetyltransferase binding ISO
    Inferred from Sequence Orthology
    more info
     
    histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
     
    lysine N-acetyltransferase activity, acting on acetyl phosphate as donor IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lysine N-acetyltransferase activity, acting on acetyl phosphate as donor ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    transcription cofactor activity ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity, transferring acyl groups IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    N-terminal peptidyl-lysine acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    histone H3 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    histone H3-K9 acetylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    histone acetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    internal peptidyl-lysine acetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    internal peptidyl-lysine acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-lysine acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of blood vessel diameter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of histone H3-K14 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of histone H3-K9 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein acetylation TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of protein ADP-ribosylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated TAS
    Traceable Author Statement
    more info
    PubMed 
    rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    A band IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Ada2/Gcn5/Ada3 transcription activator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Ada2/Gcn5/Ada3 transcription activator complex ISO
    Inferred from Sequence Orthology
    more info
     
    I band IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actomyosin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    histone acetyltransferase KAT2B
    Names
    histone acetylase PCAF
    histone acetyltransferase PCAF
    lysine acetyltransferase 2B
    p300/CBP-associated factor
    NP_001177775.1
    NP_064389.2
    XP_006523883.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190846.1NP_001177775.1  histone acetyltransferase KAT2B isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' exon and uses an alternate start codon, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC140263, AK030070
      Conserved Domains (4) summary
      cd05509
      Location:630729
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      COG5076
      Location:390729
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      pfam00583
      Location:453525
      Acetyltransf_1; Acetyltransferase (GNAT) family
      pfam06466
      Location:8229
      PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain
    2. NM_020005.4NP_064389.2  histone acetyltransferase KAT2B isoform 1

      See identical proteins and their annotated locations for NP_064389.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC131785, AC140263, BC082581
      Consensus CDS
      CCDS28880.1
      UniProtKB/Swiss-Prot
      Q9JHD1
      UniProtKB/TrEMBL
      B2RR30
      Related
      ENSMUSP00000000724.8, OTTMUSP00000050078, ENSMUST00000000724.14, OTTMUST00000091026
      Conserved Domains (4) summary
      cd05509
      Location:708807
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      COG5076
      Location:468807
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      pfam00583
      Location:531603
      Acetyltransf_1; Acetyltransferase (GNAT) family
      pfam06466
      Location:56307
      PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      53566842..53672721
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523820.3XP_006523883.1  histone acetyltransferase KAT2B isoform X1

      Conserved Domains (4) summary
      cd05509
      Location:569668
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      COG5076
      Location:329668
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      pfam00583
      Location:392464
      Acetyltransf_1; Acetyltransferase (GNAT) family
      pfam06466
      Location:1168
      PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain

    RNA

    1. XR_385299.2 RNA Sequence

    2. XR_001782056.1 RNA Sequence

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