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    Axl AXL receptor tyrosine kinase [ Mus musculus (house mouse) ]

    Gene ID: 26362, updated on 12-Mar-2017
    Official Symbol
    Axlprovided by MGI
    Official Full Name
    AXL receptor tyrosine kinaseprovided by MGI
    Primary source
    MGI:MGI:1347244
    See related
    Ensembl:ENSMUSG00000002602 Vega:OTTMUSG00000022291
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ark; Ufo; Tyro7; AI323647
    Orthologs
    Location:
    7 A3; 7 14.02 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (25756500..25788733, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (26542292..26573560, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 97 Neighboring gene heterogeneous nuclear ribonucleoprotein U-like 1 Neighboring gene predicted gene, 29763 Neighboring gene cytochrome P450, family 2, subfamily s, polypeptide 1 Neighboring gene 60S ribosomal protein L37a pseudogene

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    myosin heavy chain binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol 3-kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylserine binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    apoptotic cell clearance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    apoptotic cell clearance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    blood vessel remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to extracellular stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to interferon-alpha ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme linked receptor protein signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    erythrocyte homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    erythrocyte homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    forebrain cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    natural killer cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cytokine production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of dendritic cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of interferon-gamma production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of lymphocyte activation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of neuron apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of tumor necrosis factor production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    neuron migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neutrophil clearance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    ovulation cycle IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    phagocytosis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    phagocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    platelet activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cytokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of natural killer cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of pinocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein kinase B signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein kinase B signaling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein kinase B signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    secretion by cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spermatogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    substrate adhesion-dependent cell spreading IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vagina development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    viral entry into host cell ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    host cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    tyrosine-protein kinase receptor UFO
    Names
    adhesion-related kinase
    ufo oncogene homolog
    NP_001177903.1
    NP_001177904.1
    NP_033491.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190974.1NP_001177903.1  tyrosine-protein kinase receptor UFO isoform 2 precursor

      See identical proteins and their annotated locations for NP_001177903.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter, compared to isoform 1.
      Source sequence(s)
      AC119211, AC162614, AK033237, BC058230
      Consensus CDS
      CCDS57528.1
      UniProtKB/TrEMBL
      Q6PE80, Q8CCF8
      Related
      ENSMUSP00000083110, OTTMUSP00000025230, ENSMUST00000085948, OTTMUST00000053094
      Conserved Domains (8) summary
      cd00096
      Location:47120
      Ig; Immunoglobulin domain
      smart00221
      Location:523788
      STYKc; Protein kinase; unclassified specificity
      smart00409
      Location:35114
      IG; Immunoglobulin
      smart00410
      Location:139217
      IG_like; Immunoglobulin like
      cd00063
      Location:219322
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05075
      Location:520796
      PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
      pfam00041
      Location:329412
      fn3; Fibronectin type III domain
      cl11960
      Location:135216
      Ig; Immunoglobulin domain
    2. NM_001190975.1NP_001177904.1  tyrosine-protein kinase receptor UFO isoform 3 precursor

      See identical proteins and their annotated locations for NP_001177904.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate exons, resulting in the loss of an in-frame segment in the central coding region, compared to variant 1. The resulting protein (isoform 3) is shorter, compared to isoform 1.
      Source sequence(s)
      AC119211, AC162614
      Conserved Domains (7) summary
      cd00096
      Location:47120
      Ig; Immunoglobulin domain
      smart00221
      Location:435700
      STYKc; Protein kinase; unclassified specificity
      smart00409
      Location:35114
      IG; Immunoglobulin
      smart00410
      Location:139217
      IG_like; Immunoglobulin like
      cd00063
      Location:219322
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05075
      Location:432708
      PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
      cl11960
      Location:135216
      Ig; Immunoglobulin domain
    3. NM_009465.4NP_033491.2  tyrosine-protein kinase receptor UFO isoform 1 precursor

      See identical proteins and their annotated locations for NP_033491.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC119211, AC162614, AK033237, BC050914
      Consensus CDS
      CCDS20996.1
      UniProtKB/Swiss-Prot
      Q00993
      UniProtKB/TrEMBL
      Q8CCF8
      Related
      ENSMUSP00000002677, OTTMUSP00000025228, ENSMUST00000002677, OTTMUST00000053091
      Conserved Domains (8) summary
      cd00096
      Location:47120
      Ig; Immunoglobulin domain
      smart00221
      Location:532797
      STYKc; Protein kinase; unclassified specificity
      smart00409
      Location:35114
      IG; Immunoglobulin
      smart00410
      Location:139217
      IG_like; Immunoglobulin like
      cd00063
      Location:219322
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05075
      Location:529805
      PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
      pfam00041
      Location:329412
      fn3; Fibronectin type III domain
      cl11960
      Location:135216
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      25756500..25788733 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539993.2XP_006540056.1  tyrosine-protein kinase receptor UFO isoform X4

      Conserved Domains (7) summary
      cd00096
      Location:47120
      Ig; Immunoglobulin domain
      smart00221
      Location:426691
      STYKc; Protein kinase; unclassified specificity
      smart00409
      Location:35114
      IG; Immunoglobulin
      smart00410
      Location:139217
      IG_like; Immunoglobulin like
      cd00063
      Location:219322
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05075
      Location:423699
      PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
      cl11960
      Location:135216
      Ig; Immunoglobulin domain
    2. XM_006539991.3XP_006540054.1  tyrosine-protein kinase receptor UFO isoform X2

      See identical proteins and their annotated locations for XP_006540054.1

      UniProtKB/TrEMBL
      Q6PE80
      Conserved Domains (8) summary
      cd00096
      Location:47120
      Ig; Immunoglobulin domain
      smart00221
      Location:523788
      STYKc; Protein kinase; unclassified specificity
      smart00409
      Location:35114
      IG; Immunoglobulin
      smart00410
      Location:139217
      IG_like; Immunoglobulin like
      cd00063
      Location:219322
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05075
      Location:520796
      PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
      pfam00041
      Location:329412
      fn3; Fibronectin type III domain
      cl11960
      Location:135216
      Ig; Immunoglobulin domain
    3. XM_006539989.3XP_006540052.1  tyrosine-protein kinase receptor UFO isoform X1

      See identical proteins and their annotated locations for XP_006540052.1

      UniProtKB/Swiss-Prot
      Q00993
      Conserved Domains (8) summary
      cd00096
      Location:47120
      Ig; Immunoglobulin domain
      smart00221
      Location:532797
      STYKc; Protein kinase; unclassified specificity
      smart00409
      Location:35114
      IG; Immunoglobulin
      smart00410
      Location:139217
      IG_like; Immunoglobulin like
      cd00063
      Location:219322
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05075
      Location:529805
      PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
      pfam00041
      Location:329412
      fn3; Fibronectin type III domain
      cl11960
      Location:135216
      Ig; Immunoglobulin domain
    4. XM_006539992.2XP_006540055.1  tyrosine-protein kinase receptor UFO isoform X3

      See identical proteins and their annotated locations for XP_006540055.1

      Conserved Domains (7) summary
      cd00096
      Location:47120
      Ig; Immunoglobulin domain
      smart00221
      Location:435700
      STYKc; Protein kinase; unclassified specificity
      smart00409
      Location:35114
      IG; Immunoglobulin
      smart00410
      Location:139217
      IG_like; Immunoglobulin like
      cd00063
      Location:219322
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05075
      Location:432708
      PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
      cl11960
      Location:135216
      Ig; Immunoglobulin domain
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