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    Ar androgen receptor [ Mus musculus (house mouse) ]

    Gene ID: 11835, updated on 22-Apr-2017
    Official Symbol
    Arprovided by MGI
    Official Full Name
    androgen receptorprovided by MGI
    Primary source
    MGI:MGI:88064
    See related
    Ensembl:ENSMUSG00000046532 Vega:OTTMUSG00000018072
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tfm; AW320017
    Summary
    This gene encodes a nuclear hormone receptor containing zinc finger and DNA-binding domains. The encoded protein is a key regulator of signalling by androgens, a class of steroid hormones involved in male reproductive development. The protein responds to hormone signalling by translocating to the nucleus, forming dimers, and binding to androgen response elements (AREs) in the promoters of target genes, which are subsequently transcriptionally activated. Activity of this protein is negatively regulated by nuclear receptor subfamily 0 group B member 1 (Nr0b1, also known as Dax1). Mutations in this gene result in feminized genitals and infertility in male animals. Loss of function in female animals also causes problems in reproductive development and function. [provided by RefSeq, May 2015]
    Orthologs
    Location:
    X C3; X 42.82 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (98148757..98323218)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (95345089..95512486)

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L10 pseudogene Neighboring gene heterogeneous nuclear ribonucleoprotein M pseudogene Neighboring gene dCMP deaminase pseudogene Neighboring gene oligophrenin 1

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATPase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    POU domain binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II core promoter proximal region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    androgen binding ISO
    Inferred from Sequence Orthology
    more info
     
    androgen receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    androgen receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    androgen receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    ribonucleotide binding ISO
    Inferred from Sequence Orthology
    more info
     
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    steroid binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor activity, sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor activity, sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    Leydig cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    activation of prostate induction by androgen receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    androgen receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    androgen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    animal organ formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to steroid hormone stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to testosterone stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    copulation ISO
    Inferred from Sequence Orthology
    more info
     
    epithelial cell differentiation involved in prostate gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epithelial cell morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    fertilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    lateral sprouting involved in mammary gland duct morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    male courtship behavior ISO
    Inferred from Sequence Orthology
    more info
     
    male genitalia morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    male gonad development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    male gonad development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    male sex differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    male somatic sex determination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mammary gland alveolus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    morphogenesis of an epithelial fold IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism growth IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of integrin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of epithelial cell proliferation involved in prostate gland development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of insulin-like growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of integrin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of intracellular estrogen receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of penile erection ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase III promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    prostate gland epithelium morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    prostate gland growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein oligomerization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of catalytic activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of developmental growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of establishment of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of prostatic bud formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of systemic arterial blood pressure IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    reproductive structure development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    reproductive system development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    seminiferous tubule development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    seminiferous tubule development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    single fertilization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    single-organism reproductive behavior ISO
    Inferred from Sequence Orthology
    more info
     
    skeletal muscle hypertrophy ISO
    Inferred from Sequence Orthology
    more info
     
    spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    steroid hormone mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    tertiary branching involved in mammary gland duct morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Preferred Names
    androgen receptor
    Names
    dihydrotestosterone receptor
    nuclear receptor subfamily 3 group C member 4
    testicular feminization

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013476.4NP_038504.1  androgen receptor

      See identical proteins and their annotated locations for NP_038504.1

      Status: REVIEWED

      Source sequence(s)
      AK133647, AL683800, AL844866, M37890
      Consensus CDS
      CCDS30294.1
      UniProtKB/Swiss-Prot
      P19091
      Related
      ENSMUSP00000052648.7, OTTMUSP00000019597, ENSMUST00000052837.8, OTTMUST00000043610
      Conserved Domains (3) summary
      cd07073
      Location:652897
      NR_LBD_AR; Ligand binding domain of the nuclear receptor androgen receptor, ligand activated transcription regulator
      cd07173
      Location:534615
      NR_DBD_AR; DNA-binding domain of androgen receptor (AR) is composed of two C4-type zinc fingers
      pfam02166
      Location:6440
      Androgen_recep; Androgen receptor

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

      Range
      98148757..98323218
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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