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    PGR progesterone receptor [ Homo sapiens (human) ]

    Gene ID: 5241, updated on 8-Oct-2017
    Official Symbol
    PGRprovided by HGNC
    Official Full Name
    progesterone receptorprovided by HGNC
    Primary source
    HGNC:HGNC:8910
    See related
    Ensembl:ENSG00000082175 MIM:607311; Vega:OTTHUMG00000167531
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PR; NR3C3
    Summary
    This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce several transcript variants, both protein coding and non-protein coding. Two of the isoforms (A and B) are identical except for an additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Sep 2015]
    Orthologs
    Location:
    11q22.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 11 NC_000011.10 (101029624..101130681, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (100900355..101000544, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 42 Neighboring gene uncharacterized LOC105369457 Neighboring gene transmembrane protein 133 Neighboring gene PGR antisense RNA 1 Neighboring gene myotubularin related protein 12 pseudogene Neighboring gene uncharacterized LOC105369458

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Progesterone resistance
    MedGen: C1849699 OMIM: 264080 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
    NHGRI GWA Catalog
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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATPase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    nuclear receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    steroid binding IEA
    Inferred from Electronic Annotation
    more info
     
    steroid hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell-cell signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    epithelial cell maturation IEA
    Inferred from Electronic Annotation
    more info
     
    lung alveolus development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of gene expression IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    ovulation from ovarian follicle IEA
    Inferred from Electronic Annotation
    more info
     
    paracrine signaling IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    progesterone receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    tertiary branching involved in mammary gland duct morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    transcription initiation from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
     
    mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    progesterone receptor
    Names
    nuclear receptor subfamily 3 group C member 3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016475.1 RefSeqGene

      Range
      5001..105190
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000926.4NP_000917.3  progesterone receptor isoform B

      See identical proteins and their annotated locations for NP_000917.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (B).
      Source sequence(s)
      AP001533, M15716
      Consensus CDS
      CCDS8310.1
      UniProtKB/Swiss-Prot
      P06401
      Related
      ENSP00000325120.5, OTTHUMP00000236114, ENST00000325455.9, OTTHUMT00000394934
      Conserved Domains (3) summary
      cd07074
      Location:686933
      NR_LBD_PR; Ligand binding domain of the progesterone receptor, a member of the nuclear hormone receptor
      cd07172
      Location:563640
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02161
      Location:1564
      Prog_receptor; Progesterone receptor
    2. NM_001202474.3NP_001189403.1  progesterone receptor isoform A

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) uses a different promoter than variant 2 and has a transcription initiation site that lies just downstream of the translation start site of variant 2 (see PMID:2328727). The resulting isoform (A) is shorter at the N-terminus compared to isoform B.
      Source sequence(s)
      AP001533, M15716
      UniProtKB/Swiss-Prot
      P06401
      Conserved Domains (3) summary
      cd07074
      Location:522769
      NR_LBD_PR; Ligand binding domain of the progesterone receptor, a member of the nuclear hormone receptor
      cd07172
      Location:399476
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02161
      Location:1400
      Prog_receptor; Progesterone receptor
    3. NM_001271161.2NP_001258090.1  progesterone receptor isoform C

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the coding region, compared to variant 1, resulting in a shorter isoform (C).
      Source sequence(s)
      AB084248, AP001533
      UniProtKB/Swiss-Prot
      P06401
      Related
      ENSP00000263463.5, OTTHUMP00000236119, ENST00000263463.9, OTTHUMT00000394941
      Conserved Domains (3) summary
      cd07172
      Location:399475
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02161
      Location:1400
      Prog_receptor; Progesterone receptor
      cl11397
      Location:470667
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    4. NM_001271162.1NP_001258091.1  progesterone receptor isoform D

      See identical proteins and their annotated locations for NP_001258091.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) represents an alternate first exon, compared to variant 1, resulting in a protein isoform (D) with a shorter N-terminus.
      Source sequence(s)
      AK304853, AP001533
      Consensus CDS
      CCDS59229.1
      UniProtKB/Swiss-Prot
      P06401
      Related
      ENSP00000436561.1, OTTHUMP00000236115, ENST00000534013.5, OTTHUMT00000394935
      Conserved Domains (2) summary
      cd07074
      Location:92339
      NR_LBD_PR; Ligand binding domain of the progesterone receptor, a member of the nuclear hormone receptor
      cl02596
      Location:146
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

    RNA

    1. NR_073141.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon and represents use of an alternate splice acceptor site, compared to variant 1, which results in a premature stop codon. This variant is represented as non-coding because it is a nonsense-mediated decay (NMD) candidate.
      Source sequence(s)
      AB085845, AP001533
    2. NR_073142.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) represents use of an alternate splice acceptor site, compared to variant 1, which results in a premature stop codon. This variant is represented as non-coding because it is a nonsense-mediated decay (NMD) candidate.
      Source sequence(s)
      AB085843, AP001533
    3. NR_073143.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) omits two coding exons, compared to variant 1, which results in a premature stop codon. This variant is represented as non-coding because it is a nonsense-mediated decay (NMD) candidate.
      Source sequence(s)
      AB085683, AP001533

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p7 Primary Assembly

      Range
      101029624..101130681 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006718858.3XP_006718921.1  progesterone receptor isoform X1

      Related
      ENSP00000432352.1, OTTHUMP00000236117, ENST00000534780.5, OTTHUMT00000394939
      Conserved Domains (3) summary
      cd07172
      Location:563640
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02161
      Location:1564
      Prog_receptor; Progesterone receptor
      cl11397
      Location:686786
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    2. XM_011542869.2XP_011541171.1  progesterone receptor isoform X2

      Conserved Domains (2) summary
      pfam02161
      Location:1564
      Prog_receptor; Progesterone receptor
      cl02596
      Location:563596
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

    Alternate CHM1_1.1

    Genomic

    1. NC_018922.2 Alternate CHM1_1.1

      Range
      100783609..100883736 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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