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    Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 65248, updated on 12-Mar-2017
    Official Symbol
    Prkaa1provided by RGD
    Official Full Name
    protein kinase AMP-activated catalytic subunit alpha 1provided by RGD
    Primary source
    RGD:3387
    See related
    Ensembl:ENSRNOG00000012799
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    AMPKalpha1
    Summary
    catalytic subunit of AMP-activated protein kinase; phosphorylates hepatic acetyl-CoA carboxylase and adipose hormone-sensitive lipase [RGD, Feb 2006]
    Orthologs
    Location:
    2q16
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (54857688..54893404)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (73882080..73917812)

    Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene caspase recruitment domain family, member 6 Neighboring gene ribosomal protein L37 Neighboring gene tetratricopeptide repeat domain 33 Neighboring gene small nuclear ribonucleoprotein G pseudogene Neighboring gene prostaglandin E receptor 4

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    AMP-activated protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    AMP-activated protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    AMP-activated protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    [acetyl-CoA carboxylase] kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    eukaryotic elongation factor-2 kinase activator activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    histone serine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    histone serine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    kinase binding IPI
    Inferred from Physical Interaction
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein C-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    tau-protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    CAMKK-AMPK signaling cascade IEA
    Inferred from Electronic Annotation
    more info
     
    CAMKK-AMPK signaling cascade ISO
    Inferred from Sequence Orthology
    more info
     
    Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    activation of protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to ethanol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to glucose starvation ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to glucose starvation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to hydrogen peroxide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to nutrient levels ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to nutrient levels ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to organonitrogen compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to prostaglandin E stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to prostaglandin E stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cholesterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    cold acclimation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    fatty acid homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    fatty acid oxidation IEA
    Inferred from Electronic Annotation
    more info
     
    fatty acid oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    glucose homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    glucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    glucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    histone-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    lipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    lipid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of TOR signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of glucose import in response to insulin stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of lipid catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of lipid catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of translation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of autophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of fatty acid oxidation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gluconeogenesis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of glucose import NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of glycolytic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of skeletal muscle tissue development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of skeletal muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
     
    protein heterooligomerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    regulation of circadian rhythm ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of circadian rhythm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of energy homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to UV IEA
    Inferred from Electronic Annotation
    more info
     
    response to UV ISO
    Inferred from Sequence Orthology
    more info
     
    response to activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to caffeine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to camptothecin IEA
    Inferred from Electronic Annotation
    more info
     
    response to camptothecin ISO
    Inferred from Sequence Orthology
    more info
     
    response to gamma radiation ISO
    Inferred from Sequence Orthology
    more info
     
    response to gamma radiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide-activated protein kinase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    5'-AMP-activated protein kinase catalytic subunit alpha-1
    Names
    ACACA kinase
    AMPK alpha-1 chain
    HMGCR kinase
    acetyl-CoA carboxylase kinase
    hydroxymethylglutaryl-CoA reductase kinase
    protein kinase, AMP-activated, alpha 1 catalytic subunit
    tau-protein kinase PRKAA1
    NP_062015.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019142.2NP_062015.2  5'-AMP-activated protein kinase catalytic subunit alpha-1

      See identical proteins and their annotated locations for NP_062015.2

      Status: VALIDATED

      Source sequence(s)
      AC094562, FN804412
      UniProtKB/Swiss-Prot
      P54645
      Related
      ENSRNOP00000017626, ENSRNOT00000017626
      Conserved Domains (4) summary
      cd12199
      Location:404557
      AMPKA1_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha 1 catalytic subunit
      smart00220
      Location:27279
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14403
      Location:296360
      UBA_AID_AAPK1; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPKalpha-1)
      cd14079
      Location:24279
      STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

      Range
      54857688..54893404
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000070.1 Alternate Rn_Celera

      Range
      49888577..49923847
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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