Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    ACE2 angiotensin I converting enzyme 2 [ Homo sapiens (human) ]

    Gene ID: 59272, updated on 15-Oct-2017
    Official Symbol
    ACE2provided by HGNC
    Official Full Name
    angiotensin I converting enzyme 2provided by HGNC
    Primary source
    HGNC:HGNC:13557
    See related
    Ensembl:ENSG00000130234 MIM:300335; Vega:OTTHUMG00000021177
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ACEH
    Summary
    The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    Xp22.2
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) X NC_000023.11 (15494525..15602069, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (15579156..15620192, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene PIR-FIGF readthrough Neighboring gene vascular endothelial growth factor D Neighboring gene pirin Neighboring gene BMX non-receptor tyrosine kinase Neighboring gene uncharacterized LOC104798195 Neighboring gene prothymosin alpha-like Neighboring gene transmembrane protein 27

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • ACE Inhibitor Pathway, organism-specific biosystem (from WikiPathways)
      ACE Inhibitor Pathway, organism-specific biosystemThe core of this pathway was elucidated over a century ago and involves the conversion of angiotensinogen to angiotensin I (Ang I) by renin, its subsequent conversion to angiotensin II (Ang II) by an...
    • Metabolism of Angiotensinogen to Angiotensins, organism-specific biosystem (from REACTOME)
      Metabolism of Angiotensinogen to Angiotensins, organism-specific biosystemAngiotensinogen, a prohormone, is synthesized and secreted mainly by the liver but also from other tissues (reviewed in Fyhrquist and Saijonmaa 2008, Cat and Touyz 2011). Renin, an aspartyl protease ...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Peptide hormone metabolism, organism-specific biosystem (from REACTOME)
      Peptide hormone metabolism, organism-specific biosystemPeptide hormones are cleaved from larger precursors in the secretory system (endoplasmic reticulum, Golgi apparatus, secretory granules) of the cell. After secretion peptide hormones are modified and...
    • Protein digestion and absorption, organism-specific biosystem (from KEGG)
      Protein digestion and absorption, organism-specific biosystemProtein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancrea...
    • Protein digestion and absorption, conserved biosystem (from KEGG)
      Protein digestion and absorption, conserved biosystemProtein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancrea...
    • Renin-angiotensin system, organism-specific biosystem (from KEGG)
      Renin-angiotensin system, organism-specific biosystemThe renin-angiotensin system (RAS) is a peptidergic system with endocrine characteristics regarding to the regulation of the blood pressure and hydro-electrolytic balance. In the classical RAS, the ...
    • Renin-angiotensin system, conserved biosystem (from KEGG)
      Renin-angiotensin system, conserved biosystemThe renin-angiotensin system (RAS) is a peptidergic system with endocrine characteristics regarding to the regulation of the blood pressure and hydro-electrolytic balance. In the classical RAS, the ...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • DKFZp434A014

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    carboxypeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metallocarboxypeptidase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    NOT metallopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT peptidyl-dipeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    virus receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    virus receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    zinc ion binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    angiotensin catabolic process in blood IC
    Inferred by Curator
    more info
    PubMed 
    angiotensin maturation TAS
    Traceable Author Statement
    more info
     
    angiotensin-mediated drinking behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cardiac muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of gap junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of reactive oxygen species metabolic process IC
    Inferred by Curator
    more info
    PubMed 
    receptor biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    receptor-mediated virion attachment to host cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of blood vessel diameter IC
    Inferred by Curator
    more info
    PubMed 
    regulation of cardiac conduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of cytokine production IC
    Inferred by Curator
    more info
    PubMed 
    regulation of inflammatory response IC
    Inferred by Curator
    more info
    PubMed 
    regulation of systemic arterial blood pressure by renin-angiotensin IC
    Inferred by Curator
    more info
    PubMed 
    regulation of systemic arterial blood pressure by renin-angiotensin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of vasoconstriction IC
    Inferred by Curator
    more info
    PubMed 
    tryptophan transport IEA
    Inferred from Electronic Annotation
    more info
     
    viral entry into host cell TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane raft TAS
    Traceable Author Statement
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    angiotensin-converting enzyme 2
    Names
    ACE-related carboxypeptidase
    angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
    angiotensin-converting enzyme homolog
    metalloprotease MPROT15
    peptidyl-dipeptidase A
    NP_068576.1
    XP_011543851.1
    XP_011543853.1
    XP_011543854.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012575.1 RefSeqGene

      Range
      5001..46037
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_021804.2NP_068576.1  angiotensin-converting enzyme 2 precursor

      See identical proteins and their annotated locations for NP_068576.1

      Status: REVIEWED

      Source sequence(s)
      AB193259
      Consensus CDS
      CCDS14169.1
      UniProtKB/Swiss-Prot
      Q9BYF1
      Related
      ENSP00000389326.1, ENST00000427411.1
      Conserved Domains (2) summary
      pfam01401
      Location:19606
      Peptidase_M2; Angiotensin-converting enzyme
      pfam16959
      Location:617770
      Collectrin; Renal amino acid transporter

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p7 Primary Assembly

      Range
      15494525..15602069 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011545551.2XP_011543853.1  angiotensin-converting enzyme 2 isoform X2

      Conserved Domains (2) summary
      pfam01401
      Location:19606
      Peptidase_M2; Angiotensin-converting enzyme
      pfam16959
      Location:617770
      Collectrin; Renal amino acid transporter
    2. XM_011545549.1XP_011543851.1  angiotensin-converting enzyme 2 isoform X1

      Conserved Domains (2) summary
      pfam01401
      Location:19606
      Peptidase_M2; Angiotensin-converting enzyme
      pfam16959
      Location:617770
      Collectrin; Renal amino acid transporter
    3. XM_011545552.1XP_011543854.1  angiotensin-converting enzyme 2 isoform X3

      Conserved Domains (2) summary
      pfam01401
      Location:19556
      Peptidase_M2; Angiotensin-converting enzyme
      pfam16959
      Location:556659
      Collectrin; Renal amino acid transporter

    Alternate CHM1_1.1

    Genomic

    1. NC_018934.2 Alternate CHM1_1.1

      Range
      15610102..15651154 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center