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    Parp1 poly (ADP-ribose) polymerase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25591, updated on 22-Apr-2018
    Official Symbol
    Parp1provided by RGD
    Official Full Name
    poly (ADP-ribose) polymerase 1provided by RGD
    Primary source
    RGD:2053
    See related
    Ensembl:ENSRNOG00000003084
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ARTD1; Adprt; Parp-1
    Summary
    catalyzes poly (ADP-ribose) protein modification; plays a role in DNA repair and genome stability [RGD, Feb 2006]
    Expression
    Biased expression in Heart (RPKM 435.6), Spleen (RPKM 270.7) and 9 other tissues See more
    Orthologs
    Location:
    13q26
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (98857255..98889444)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 13 NC_005112.3 (103859760..103891949)

    Chromosome 13 - NC_005112.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352582 Neighboring gene inositol-trisphosphate 3-kinase B Neighboring gene stum, mechanosensory transduction mediator homolog Neighboring gene Mix paired-like homeobox Neighboring gene lin-9 DREAM MuvB core complex component

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC93658

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    DNA ligase (ATP) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    NAD binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NAD+ ADP-ribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NAD+ ADP-ribosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NAD+ ADP-ribosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    R-SMAD binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    RNA polymerase II regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    SMAD binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    estrogen receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    histone deacetylase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein ADP-ribosylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein ADP-ribosylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein N-terminus binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein N-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity, transferring pentosyl groups NAS
    Non-traceable Author Statement
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    ATP generation from poly-ADP-D-ribose ISO
    Inferred from Sequence Orthology
    more info
     
    ATP generation from poly-ADP-D-ribose ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    DNA damage response, detection of DNA damage IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA ligation involved in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    DNA metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    base-excision repair ISO
    Inferred from Sequence Orthology
    more info
     
    behavioral response to cocaine ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to UV IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to UV ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to amyloid-beta IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to insulin stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to superoxide ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to transforming growth factor beta stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to zinc ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
     
    double-strand break repair ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lagging strand elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    mitochondrial DNA metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of ATP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of ATP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of interleukin-17 secretion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of telomere maintenance via telomere lengthening ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-serine ADP-ribosylation ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-serine ADP-ribosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of SMAD protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cardiac muscle hypertrophy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of intracellular estrogen receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of mitochondrial depolarization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of myofibroblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neuron death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein localization to nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of single strand break repair IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of single strand break repair ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription regulatory region DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein ADP-ribosylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein ADP-ribosylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein ADP-ribosylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein autoprocessing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein modification process ISO
    Inferred from Sequence Orthology
    more info
     
    protein poly-ADP-ribosylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein poly-ADP-ribosylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of DNA methylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of SMAD protein complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of catalytic activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cellular protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of growth rate ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of single strand break repair ISO
    Inferred from Sequence Orthology
    more info
     
    response to aldosterone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to gamma radiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    signal transduction involved in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    telomere maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    transforming growth factor beta receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    voluntary musculoskeletal movement ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein-DNA complex IEA
    Inferred from Electronic Annotation
    more info
     
    protein-DNA complex ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor complex IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    poly [ADP-ribose] polymerase 1
    Names
    ADP-ribosyltransferase (NAD+
    ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)
    ADP-ribosyltransferase 1
    ADP-ribosyltransferase diphtheria toxin-like 1
    ADPRT 1
    NAD(+) ADP-ribosyltransferase 1
    poly (ADP-ribose) polymerase family, member 1
    poly (ADP-ribose) polymerase)
    poly(ADP-ribose) polymerase PARP-1
    poly[ADP-ribose] synthase 1
    poly[ADP-ribose] synthetase 1
    NP_037195.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013063.2NP_037195.1  poly [ADP-ribose] polymerase 1

      See identical proteins and their annotated locations for NP_037195.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085765
      UniProtKB/Swiss-Prot
      P27008
      Related
      ENSRNOP00000004232.3, ENSRNOT00000004232.5
      Conserved Domains (6) summary
      cd08001
      Location:543645
      WGR_PARP1_like; WGR domain of poly(ADP-ribose) polymerase 1 and similar proteins
      PLN03123
      Location:91010
      PLN03123; poly [ADP-ribose] polymerase; Provisional
      cd01437
      Location:6621006
      parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
      pfam00533
      Location:389462
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam00645
      Location:1287
      zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
      pfam08063
      Location:281332
      PADR1; PADR1 (NUC008) domain

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005112.4 Reference Rnor_6.0 Primary Assembly

      Range
      98857255..98889444
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000081.1 Alternate Rn_Celera

      Range
      91853812..91885580
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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