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    NCBP2 nuclear cap binding protein subunit 2 [ Homo sapiens (human) ]

    Gene ID: 22916, updated on 25-May-2017
    Official Symbol
    NCBP2provided by HGNC
    Official Full Name
    nuclear cap binding protein subunit 2provided by HGNC
    Primary source
    HGNC:HGNC:7659
    See related
    Ensembl:ENSG00000114503 MIM:605133; Vega:OTTHUMG00000155520
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CBC2; NIP1; CBP20; PIG55
    Summary
    The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein has an RNP domain commonly found in RNA binding proteins, and contains the cap-binding activity. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    3q29
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 3 NC_000003.12 (196935402..196942594, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (196662273..196669464, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene p21 (RAC1) activated kinase 2 Neighboring gene RNA, U6 small nuclear 42, pseudogene Neighboring gene SUMO1/sentrin specific peptidase 5 Neighboring gene NCBP2 antisense RNA 2 (head to head) Neighboring gene phosphatidylinositol glycan anchor biosynthesis class Z

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Abortive elongation of HIV-1 transcript in the absence of Tat, organism-specific biosystem (from REACTOME)
      Abortive elongation of HIV-1 transcript in the absence of Tat, organism-specific biosystemThis event was inferred from the corresponding Reactome human Poll II transcription elongation event. The details specific to HIV-1 transcription elongation are described below. In the absence of th...
    • Cap binding complex, organism-specific biosystem (from KEGG)
      Cap binding complex, organism-specific biosystemStructural complex; Genetic information processing; Spliceosome
    • Cap binding complex, conserved biosystem (from KEGG)
      Cap binding complex, conserved biosystemStructural complex; Genetic information processing; Spliceosome
    • Cleavage of Growing Transcript in the Termination Region, organism-specific biosystem (from REACTOME)
      Cleavage of Growing Transcript in the Termination Region, organism-specific biosystemThis section includes the cleavage of both polyadenylated and non-polyadenylated transcripts. In the former case polyadenylation has to precede transcript cleavage, while in the latter case there is ...
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Diseases of signal transduction, organism-specific biosystem (from REACTOME)
      Diseases of signal transduction, organism-specific biosystemSignaling processes are central to human physiology (e.g., Pires-da Silva & Sommer 2003), and their disruption by either germ-line and somatic mutation can lead to serious disease. Here, the molecula...
    • FGFR2 alternative splicing, organism-specific biosystem (from REACTOME)
      FGFR2 alternative splicing, organism-specific biosystemAlternative splicing of the FGFR2 nascent mRNA generates an epithelial specific isoform (FGFR2 IIIb) and a mesenchymal specific isoform (FGFR2 IIIc). The inclusion of exon 8 in FGFR2 IIIb or exon 9 ...
    • FGFR2 mutant receptor activation, organism-specific biosystem (from REACTOME)
      FGFR2 mutant receptor activation, organism-specific biosystemAutosomal dominant mutations in FGFR2 are associated with the development of a range of skeletal disorders including Beare-Stevensen cutis gyrata syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome, ...
    • Formation of HIV elongation complex in the absence of HIV Tat, organism-specific biosystem (from REACTOME)
      Formation of HIV elongation complex in the absence of HIV Tat, organism-specific biosystem
      Formation of HIV elongation complex in the absence of HIV Tat
    • Formation of HIV-1 elongation complex containing HIV-1 Tat, organism-specific biosystem (from REACTOME)
      Formation of HIV-1 elongation complex containing HIV-1 Tat, organism-specific biosystemThis HIV-1 event was inferred from the corresponding human RNA Poll II transcription event in Reactome. The details relevant to HIV-1 are described below. For a more detailed description of the gener...
    • Formation of RNA Pol II elongation complex, organism-specific biosystem (from REACTOME)
      Formation of RNA Pol II elongation complex, organism-specific biosystemTFIIS is a transcription factor involved in different phases of transcription, occurring in a major ubiquitous form and other tissue specific forms. TFIIS stimulates RNA Pol II complex out of elonga...
    • Formation of the Early Elongation Complex, organism-specific biosystem (from REACTOME)
      Formation of the Early Elongation Complex, organism-specific biosystemTranscription elongation by RNA polymerase II (RNAPII) is controlled by a number of trans-acting transcription elongation factors as well as by cis-acting elements. Transcription elongation is a rat...
    • Formation of the HIV-1 Early Elongation Complex, organism-specific biosystem (from REACTOME)
      Formation of the HIV-1 Early Elongation Complex, organism-specific biosystemThis HIV-1 event was inferred from the corresponding human RNA Poll II transcription event. The details relevant to HIV-1 are described below. Formation of the early elongation complex involves hypo...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • HIV Infection, organism-specific biosystem (from REACTOME)
      HIV Infection, organism-specific biosystemThe global pandemic of Human Immunodeficiency Virus (HIV) infection has resulted in tens of millions of people infected by the virus and millions more affected. UNAIDS estimates around 40 million ...
    • HIV Life Cycle, organism-specific biosystem (from REACTOME)
      HIV Life Cycle, organism-specific biosystemThe life cycle of HIV-1 is divided into early and late phases, shown schematically in the figure. In the early phase, an HIV-1 virion binds to receptors and co-receptors on the human host cell surfac...
    • HIV Transcription Elongation, organism-specific biosystem (from REACTOME)
      HIV Transcription Elongation, organism-specific biosystemIn the absence of the HIV-1 protein Tat, transcription of the proviral DNA is inefficient and results in the production of truncated transcripts (Kao et al., 1987). While initiation of transcription ...
    • Infectious disease, organism-specific biosystem (from REACTOME)
      Infectious disease, organism-specific biosystem
      Infectious disease
    • Late Phase of HIV Life Cycle, organism-specific biosystem (from REACTOME)
      Late Phase of HIV Life Cycle, organism-specific biosystemThe late phase of the HIV-1 life cycle includes the regulated expression of the HIV gene products and the assembly of viral particles. The assembly of viral particles will be covered in a later relea...
    • Metabolism of non-coding RNA, organism-specific biosystem (from REACTOME)
      Metabolism of non-coding RNA, organism-specific biosystemThe term non-coding is commonly employed for RNA that does not encode a protein, but this does not mean that such RNAs do not contain information nor have function. There is considerable evidence tha...
    • Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), organism-specific biosystem (from REACTOME)
      Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), organism-specific biosystemDuring normal translation termination eRF3 associates with the ribosome and then interacts with PABP bound to the polyadenylate tail of the mRNA to release the ribosome and allow a new round of trans...
    • Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), organism-specific biosystem (from REACTOME)
      Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), organism-specific biosystemNonsense-mediated decay has been observed with mRNAs that do not have an exon junction complex (EJC) downstream of the termination codon (reviewed in Isken and Maquat 2007, Chang et al. 2007, Behm-An...
    • Nonsense-Mediated Decay (NMD), organism-specific biosystem (from REACTOME)
      Nonsense-Mediated Decay (NMD), organism-specific biosystemThe Nonsense-Mediated Decay (NMD) pathway activates the destruction of mRNAs containing premature termination codons (PTCs) (reviewed in Isken and Maquat 2007, Chang et al. 2007, Behm-Ansmant et al. ...
    • Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem (from REACTOME)
      Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystemCo-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per ge...
    • Processing of Capped Intronless Pre-mRNA, organism-specific biosystem (from REACTOME)
      Processing of Capped Intronless Pre-mRNA, organism-specific biosystemCo-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per ge...
    • Processing of Intronless Pre-mRNAs, organism-specific biosystem (from REACTOME)
      Processing of Intronless Pre-mRNAs, organism-specific biosystemThe 3' ends of eukaryotic mRNAs are generated by posttranscriptional processing of an extended primary transcript. For almost all RNAs, 3' processing consists of two steps: The mRNA is first cleaved ...
    • RNA Polymerase II Pre-transcription Events, organism-specific biosystem (from REACTOME)
      RNA Polymerase II Pre-transcription Events, organism-specific biosystem
      RNA Polymerase II Pre-transcription Events
    • RNA Polymerase II Transcription, organism-specific biosystem (from REACTOME)
      RNA Polymerase II Transcription, organism-specific biosystem
      RNA Polymerase II Transcription
    • RNA Polymerase II Transcription Elongation, organism-specific biosystem (from REACTOME)
      RNA Polymerase II Transcription Elongation, organism-specific biosystemThe mechanisms governing the process of elongation during eukaryotic mRNA synthesis are being unraveled by recent studies. These studies have led to the expected discovery of a diverse collection of ...
    • RNA Polymerase II Transcription Termination, organism-specific biosystem (from REACTOME)
      RNA Polymerase II Transcription Termination, organism-specific biosystemThe detailed annotation of this section will be completed in the next release.
    • RNA polymerase II transcribes snRNA genes, organism-specific biosystem (from REACTOME)
      RNA polymerase II transcribes snRNA genes, organism-specific biosystemSmall nuclear RNAs (snRNAs) play key roles in splicing and some of them, specifically the U1 and U2 snRNAs, are encoded by multicopy snRNA gene clusters containing tandem arrays of genes, about 30 in...
    • RNA transport, organism-specific biosystem (from KEGG)
      RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • RNA transport, conserved biosystem (from KEGG)
      RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs, organism-specific biosystem (from REACTOME)
      SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs, organism-specific biosystemThere are two well-documented trans-acting factors required for histone pre-mRNA processing. These are:1 Stem-loop binding protein (SLBP), also termed hairpin binding protein (HBP). This 32 kDa pro...
    • SLBP independent Processing of Histone Pre-mRNAs, organism-specific biosystem (from REACTOME)
      SLBP independent Processing of Histone Pre-mRNAs, organism-specific biosystemThis class of mRNAs is expressed from genes that lack introns yet the transcripts end in polyA tails. These tails are formed by a mechanism similar to that for pre-mRNAs containing introns. It is ...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by FGFR, organism-specific biosystem (from REACTOME)
      Signaling by FGFR, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
    • Signaling by FGFR in disease, organism-specific biosystem (from REACTOME)
      Signaling by FGFR in disease, organism-specific biosystemA number of skeletal and developmental diseases have been shown to arise as a result of mutations in the FGFR1, 2 and 3 genes. These include dwarfism syndromes (achondroplasia, hypochondroplasia and...
    • Signaling by FGFR2, organism-specific biosystem (from REACTOME)
      Signaling by FGFR2, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
    • Signaling by FGFR2 IIIa TM, organism-specific biosystem (from REACTOME)
      Signaling by FGFR2 IIIa TM, organism-specific biosystemA soluble truncated form of FGFR2 is aberrantly expressed in an Apert Syndrome mouse model and inhibits FGFR signaling in vitro and in vivo. This variant, termed FGFR IIIa TM, arises from an misspli...
    • Signaling by FGFR2 in disease, organism-specific biosystem (from REACTOME)
      Signaling by FGFR2 in disease, organism-specific biosystemThe FGFR2 gene has been shown to be subject to activating mutations and gene amplification leading to a variety of proliferative and developmental disorders depending on whether these events occur in...
    • Spliceosome, organism-specific biosystem (from KEGG)
      Spliceosome, organism-specific biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
    • Spliceosome, conserved biosystem (from KEGG)
      Spliceosome, conserved biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
    • Tat-mediated elongation of the HIV-1 transcript, organism-specific biosystem (from REACTOME)
      Tat-mediated elongation of the HIV-1 transcript, organism-specific biosystemThe Tat protein is a viral transactivator protein that regulates HIV-1 gene expression by controlling RNA Pol II-mediated elongation (reviewed in Karn 1999; Taube et al. 1999; Liou et al. 2004; Barb...
    • Transcription of the HIV genome, organism-specific biosystem (from REACTOME)
      Transcription of the HIV genome, organism-specific biosystemExpression of the integrated HIV-1 provirus is dependent on the host cell Pol II transcription machinery, but is regulated in critical ways by HIV-1 Tat and Rev proteins. The long terminal repeats (L...
    • Transport of Mature Transcript to Cytoplasm, organism-specific biosystem (from REACTOME)
      Transport of Mature Transcript to Cytoplasm, organism-specific biosystemTransport of mRNA through the Nuclear Pore Complex (NPC) is a dynamic process involving distinct machinery and receptor subsets. The separation of the two compartments and the regulation of this tran...
    • Transport of Mature mRNA Derived from an Intronless Transcript, organism-specific biosystem (from REACTOME)
      Transport of Mature mRNA Derived from an Intronless Transcript, organism-specific biosystemTransport of mRNA from the nucleus to the cytoplasm, where it is translated into protein, is highly selective and closely coupled to correct RNA processing.
    • Transport of Mature mRNA derived from an Intron-Containing Transcript, organism-specific biosystem (from REACTOME)
      Transport of Mature mRNA derived from an Intron-Containing Transcript, organism-specific biosystemTransport of mRNA from the nucleus to the cytoplasm, where it is translated into protein, is highly selective and closely coupled to correct RNA processing. This coupling is achieved by the nuclear p...
    • Transport of Mature mRNAs Derived from Intronless Transcripts, organism-specific biosystem (from REACTOME)
      Transport of Mature mRNAs Derived from Intronless Transcripts, organism-specific biosystemTransport of mature mRNAs derived from intronless transcripts require some of the same protein complexes as mRNAs derived from intron containing complexes, including TAP and Aly/Ref. However a number...
    • Transport of the SLBP Dependant Mature mRNA, organism-specific biosystem (from REACTOME)
      Transport of the SLBP Dependant Mature mRNA, organism-specific biosystemTransport of U7 snRNP and stem-loop binding protein (SLBP) processed mRNA.
    • Transport of the SLBP independent Mature mRNA, organism-specific biosystem (from REACTOME)
      Transport of the SLBP independent Mature mRNA, organism-specific biosystemTransport of the SLBP independent Mature mRNA through the nuclear pore.
    • mRNA 3'-end processing, organism-specific biosystem (from REACTOME)
      mRNA 3'-end processing, organism-specific biosystemThe 3' ends of eukaryotic mRNAs are generated by posttranscriptional processing of an extended primary transcript. For almost all RNAs, 3'-end processing consists of two steps: (i) the mRNA is first ...
    • mRNA Capping, organism-specific biosystem (from REACTOME)
      mRNA Capping, organism-specific biosystemThe 5'-ends of all eukaryotic pre-mRNAs studied thus far are converted to cap structures. The cap is thought to influence splicing of the first intron, and is bound by 'cap-binding' proteins, CBP80 a...
    • mRNA Processing, organism-specific biosystem (from WikiPathways)
      mRNA Processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' po...
    • mRNA Splicing, organism-specific biosystem (from REACTOME)
      mRNA Splicing, organism-specific biosystemThe process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, is called mRNA splicing...
    • mRNA Splicing - Major Pathway, organism-specific biosystem (from REACTOME)
      mRNA Splicing - Major Pathway, organism-specific biosystemThe splicing of pre-mRNA occurs within a large, very dynamic complex, designated the 'spliceosome'. The 50-60S spliceosomes are estimated to be 40-60 nm in diameter, and have molecular weights in the...
    • mRNA Splicing - Minor Pathway, organism-specific biosystem (from REACTOME)
      mRNA Splicing - Minor Pathway, organism-specific biosystemThe splicing of a subset of pre-mRNA introns occurs by a second pathway, designated the AT-AC or U12-dependent splicing pathway. AT-AC introns have highly conserved, non-canonical splice sites that ...
    • mRNA surveillance pathway, organism-specific biosystem (from KEGG)
      mRNA surveillance pathway, organism-specific biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
    • mRNA surveillance pathway, conserved biosystem (from KEGG)
      mRNA surveillance pathway, conserved biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
    • snRNP Assembly, organism-specific biosystem (from REACTOME)
      snRNP Assembly, organism-specific biosystemSmall nuclear ribonucleoproteins (snRNPs) are crucial for pre-mRNA processing to mRNAs. Each snRNP contains a small nuclear RNA (snRNA) and an extremely stable core of seven Sm proteins. The U6 snRNA...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA 7-methylguanosine cap binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA 7-methylguanosine cap binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA cap binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    snRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    7-methylguanosine mRNA capping TAS
    Traceable Author Statement
    more info
     
    RNA export from nucleus TAS
    Traceable Author Statement
    more info
     
    RNA metabolic process TAS
    Traceable Author Statement
    more info
     
    RNA splicing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    fibroblast growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    gene silencing by RNA IEA
    Inferred from Electronic Annotation
    more info
     
    histone mRNA metabolic process TAS
    Traceable Author Statement
    more info
     
    mRNA 3'-end processing TAS
    Traceable Author Statement
    more info
     
    mRNA cis splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mRNA export from nucleus TAS
    Traceable Author Statement
    more info
     
    mRNA splicing, via spliceosome TAS
    Traceable Author Statement
    more info
     
    nuclear export TAS
    Traceable Author Statement
    more info
     
    nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
    Traceable Author Statement
    more info
     
    positive regulation of RNA export from nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of mRNA 3'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    pre-mRNA cleavage required for polyadenylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT regulation of mRNA polyadenylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of translational initiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    snRNA export from nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    snRNA export from nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 
    snRNA transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
     
    termination of RNA polymerase II transcription TAS
    Traceable Author Statement
    more info
     
    transcription elongation from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
     
    transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    RNA cap binding complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    mRNA cap binding complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear cap binding complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Preferred Names
    nuclear cap-binding protein subunit 2
    Names
    20 kDa nuclear cap-binding protein
    NCBP 20 kDa subunit
    NCBP interacting protein 1
    cell proliferation-inducing gene 55 protein
    nuclear cap binding protein subunit 2, 20kD
    nuclear cap binding protein subunit 2, 20kDa

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042540.1NP_001036005.1  nuclear cap-binding protein subunit 2 isoform 2

      See identical proteins and their annotated locations for NP_001036005.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
      Source sequence(s)
      AC011322, AW440347, BC001255, BP248419, CN421262
      Consensus CDS
      CCDS46986.1
      UniProtKB/Swiss-Prot
      P52298
      Related
      ENSP00000397619.2, OTTHUMP00000208153, ENST00000427641.2, OTTHUMT00000340473
      Conserved Domains (1) summary
      cl17169
      Location:4166
      RRM_SF; RNA recognition motif (RRM) superfamily
    2. NM_001308036.1NP_001294965.1  nuclear cap-binding protein subunit 2 isoform 3

      See identical proteins and their annotated locations for NP_001294965.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate 5' exon and contains an alternate 5' terminal exon, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK297506, AW440347, BC001255, DC375323
      Consensus CDS
      CCDS77878.1
      UniProtKB/Swiss-Prot
      P52298
      Related
      ENSP00000412785.2, OTTHUMP00000208155, ENST00000452404.6, OTTHUMT00000340475
      Conserved Domains (2) summary
      COG0724
      Location:21122
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12240
      Location:24101
      RRM_NCBP2; RNA recognition motif found in nuclear cap-binding protein subunit 2 (CBP20) and similar proteins
    3. NM_007362.3NP_031388.2  nuclear cap-binding protein subunit 2 isoform 1

      See identical proteins and their annotated locations for NP_031388.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC011322, AW440347, BC001255, BP248419
      Consensus CDS
      CCDS3323.1
      UniProtKB/Swiss-Prot
      P52298
      Related
      ENSP00000326806.5, OTTHUMP00000208152, ENST00000321256.9, OTTHUMT00000340470
      Conserved Domains (2) summary
      COG0724
      Location:39140
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12240
      Location:42119
      RRM_NCBP2; RNA recognition motif found in nuclear cap-binding protein subunit 2 (CBP20) and similar proteins

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p7 Primary Assembly

      Range
      196935402..196942594 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011512556.2XP_011510858.1  nuclear cap-binding protein subunit 2 isoform X1

      See identical proteins and their annotated locations for XP_011510858.1

      UniProtKB/TrEMBL
      B3KSB0
      Related
      ENSP00000389315.1, OTTHUMP00000208157, ENST00000411704.1, OTTHUMT00000340479
      Conserved Domains (2) summary
      COG0724
      Location:170
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12240
      Location:149
      RRM_NCBP2; RNA recognition motif found in nuclear cap-binding protein subunit 2 (CBP20) and similar proteins
    2. XM_011512557.2XP_011510859.1  nuclear cap-binding protein subunit 2 isoform X1

      See identical proteins and their annotated locations for XP_011510859.1

      UniProtKB/TrEMBL
      B3KSB0
      Related
      ENSP00000413518.1, OTTHUMP00000208156, ENST00000447325.5, OTTHUMT00000340476
      Conserved Domains (2) summary
      COG0724
      Location:170
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12240
      Location:149
      RRM_NCBP2; RNA recognition motif found in nuclear cap-binding protein subunit 2 (CBP20) and similar proteins
    3. XM_011512558.2XP_011510860.1  nuclear cap-binding protein subunit 2 isoform X1

      See identical proteins and their annotated locations for XP_011510860.1

      UniProtKB/TrEMBL
      B3KSB0
      Related
      ENSP00000394105.1, OTTHUMP00000208158, ENST00000422610.5, OTTHUMT00000340480
      Conserved Domains (2) summary
      COG0724
      Location:170
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12240
      Location:149
      RRM_NCBP2; RNA recognition motif found in nuclear cap-binding protein subunit 2 (CBP20) and similar proteins

    Alternate CHM1_1.1

    Genomic

    1. NC_018914.2 Alternate CHM1_1.1

      Range
      196633623..196640813 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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