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    Nrap nebulin-related anchoring protein [ Mus musculus (house mouse) ]

    Gene ID: 18175, updated on 5-Nov-2017
    Official Symbol
    Nrapprovided by MGI
    Official Full Name
    nebulin-related anchoring proteinprovided by MGI
    Primary source
    MGI:MGI:1098765
    See related
    Ensembl:ENSMUSG00000049134 Vega:OTTMUSG00000036778
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Orthologs
    Location:
    19 D2; 19 51.8 cM
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (56320037..56390063, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (56394531..56464525, complement)

    Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 32144 Neighboring gene predicted gene, 32257 Neighboring gene hyaluronic acid binding protein 2 Neighboring gene predicted gene 17197 Neighboring gene caspase 7 Neighboring gene predicted gene, 46657

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    actin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    muscle alpha-actinin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    vinculin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    actin cytoskeleton organization TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    fascia adherens IDA
    Inferred from Direct Assay
    more info
    PubMed 
    muscle tendon junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myofibril IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    nebulin-related-anchoring protein
    Names
    N-RAP
    nrap

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286552.1NP_001273481.1  nebulin-related-anchoring protein isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in its 5' UTR, lacks an in-frame exon in the central coding region, and initiates translation at a downstream start codon, compared to variant 2. The encoded isoform (3) is shorter, compared to isoform S.
      Source sequence(s)
      AC115771, AV245044, AY177622, AY177623
      UniProtKB/Swiss-Prot
      Q80XB4
      Conserved Domains (2) summary
      smart00227
      Location:404434
      NEBU; The Nebulin repeat is present also in Las1
      pfam00880
      Location:232258
      Nebulin; Nebulin repeat
    2. NM_008733.4NP_032759.3  nebulin-related-anchoring protein isoform S

      See identical proteins and their annotated locations for NP_032759.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (S).
      Source sequence(s)
      AC115771, AV245044, AY177622, AY177623
      Consensus CDS
      CCDS29913.1
      UniProtKB/Swiss-Prot
      Q80XB4
      Related
      ENSMUSP00000073228.6, OTTMUSP00000052478, ENSMUST00000073536.12, OTTMUST00000094390
      Conserved Domains (3) summary
      smart00227
      Location:520550
      NEBU; The Nebulin repeat is present also in Las1
      cd09446
      Location:658
      LIM_N_RAP; The LIM domain of N-RAP
      pfam00880
      Location:313339
      Nebulin; Nebulin repeat
    3. NM_198059.3NP_932307.2  nebulin-related-anchoring protein isoform C

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks an in-frame exon in the central coding region, compared to variant 2. The encoded isoform (C) is shorter, compared to isoform S.
      Source sequence(s)
      AC115771, AV245044, AY177622, AY177623
      Consensus CDS
      CCDS29914.1
      UniProtKB/Swiss-Prot
      Q80XB4
      Related
      ENSMUSP00000048364.8, OTTMUSP00000052477, ENSMUST00000040711.14, OTTMUST00000094389
      Conserved Domains (3) summary
      smart00227
      Location:485515
      NEBU; The Nebulin repeat is present also in Las1
      cd09446
      Location:658
      LIM_N_RAP; The LIM domain of N-RAP
      pfam00880
      Location:313339
      Nebulin; Nebulin repeat

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

      Range
      56320037..56390063 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526747.3XP_006526810.1  nebulin-related-anchoring protein isoform X3

      Conserved Domains (2) summary
      smart00227
      Location:439469
      NEBU; The Nebulin repeat is present also in Las1
      pfam00880
      Location:232258
      Nebulin; Nebulin repeat
    2. XM_006526746.3XP_006526809.1  nebulin-related-anchoring protein isoform X2

      Conserved Domains (3) summary
      smart00227
      Location:486516
      NEBU; The Nebulin repeat is present also in Las1
      cd09446
      Location:658
      LIM_N_RAP; The LIM domain of N-RAP
      pfam00880
      Location:314340
      Nebulin; Nebulin repeat
    3. XM_006526745.3XP_006526808.1  nebulin-related-anchoring protein isoform X1

      Conserved Domains (3) summary
      smart00227
      Location:521551
      NEBU; The Nebulin repeat is present also in Las1
      cd09446
      Location:658
      LIM_N_RAP; The LIM domain of N-RAP
      pfam00880
      Location:314340
      Nebulin; Nebulin repeat
    4. XM_006526748.3XP_006526811.1  nebulin-related-anchoring protein isoform X4

      UniProtKB/Swiss-Prot
      Q80XB4
      Related
      ENSMUSP00000093640.4, OTTMUSP00000052479, ENSMUST00000095947.10, OTTMUST00000094391
      Conserved Domains (2) summary
      smart00227
      Location:403433
      NEBU; The Nebulin repeat is present also in Las1
      pfam00880
      Location:231257
      Nebulin; Nebulin repeat
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