Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    Dlx5 distal-less homeobox 5 [ Mus musculus (house mouse) ]

    Gene ID: 13395, updated on 8-Oct-2017
    Official Symbol
    Dlx5provided by MGI
    Official Full Name
    distal-less homeobox 5provided by MGI
    Primary source
    MGI:MGI:101926
    See related
    Ensembl:ENSMUSG00000029755 Vega:OTTMUSG00000021177
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI385752
    Orthologs
    Location:
    6 A1; 6 2.83 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (6877801..6882068, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (6827805..6832068, complement)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105242595 Neighboring gene distal-less homeobox 6, opposite strand 1 Neighboring gene distal-less homeobox 6, opposite strand 2 Neighboring gene distal-less homeobox 6 Neighboring gene succinate dehydrogenase complex assembly factor 3 Neighboring gene centromere protein E pseudogene

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    anatomical structure formation involved in morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    bone morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to BMP stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ear development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic limb morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    endochondral ossification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epithelial cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    face morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    head development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    inner ear morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    inner ear morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    interneuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    olfactory bulb interneuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    olfactory pit development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ossification IEA
    Inferred from Electronic Annotation
    more info
     
    osteoblast differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    palate development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    palate development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of epithelial cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010056.3NP_034186.2  homeobox protein DLX-5 isoform 1

      See identical proteins and their annotated locations for NP_034186.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AF033011, AF072452, U67840
      Consensus CDS
      CCDS19905.1
      UniProtKB/Swiss-Prot
      P70396
      UniProtKB/TrEMBL
      Q3TYA7
      Related
      ENSMUSP00000052559.8, OTTMUSP00000023382, ENSMUST00000052609.8, OTTMUST00000050166
      Conserved Domains (2) summary
      pfam00046
      Location:140193
      Homeobox; Homeobox domain
      pfam12413
      Location:32118
      DLL_N; Homeobox protein distal-less-like N terminal
    2. NM_198854.2NP_942151.1  homeobox protein DLX-5 isoform 2

      See identical proteins and their annotated locations for NP_942151.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the central coding region, resulting in a frameshift and an early stop codon, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AF072453, U67840
      Consensus CDS
      CCDS59691.1
      UniProtKB/Swiss-Prot
      P70396
      Related
      ENSMUSP00000138264.1, OTTMUSP00000065257, ENSMUST00000142635.1, OTTMUST00000050167
      Conserved Domains (1) summary
      pfam12413
      Location:32118
      DLL_N; Homeobox protein distal-less-like N terminal

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      6877801..6882068 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504980.2XP_006505043.1  homeobox protein DLX-5 isoform X1

      See identical proteins and their annotated locations for XP_006505043.1

      Conserved Domains (1) summary
      pfam00046
      Location:4598
      Homeobox; Homeobox domain
    2. XM_006504981.2XP_006505044.1  homeobox protein DLX-5 isoform X1

      See identical proteins and their annotated locations for XP_006505044.1

      Conserved Domains (1) summary
      pfam00046
      Location:4598
      Homeobox; Homeobox domain
    Support Center